# US 11,027,218 B2 · Purification and separation techniques for cannabinoids

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- Number: US 11,027,218 B2
- Document ID: US11027218B2
- Status: Granted
- Kind: B2
- Application number: 16/308,421
- Filed: 2017-06-09
- Published: 2019-06-27
- Granted: 2021-06-08
- Earliest claimed: 2016-06-10
- Assignees: Canopy Growth Corporation
- Applicants: Canopy Growth Corporation
- Inventors: Kurt Aron Levy; Karl Enmark
- Web page: https://patentgrep.com/patent/US11027218B2

## CPC

- B01D 11/0292: {Treatment of the solvent}
- B01D 9/0018: {Evaporation of components of the mixture to be separated}
- B01D 11/02: of solids
- B01D 11/0207: {Control systems}
- B01D 11/0265: {Applying ultrasound}
- B01D 11/0288: {Applications, solvents}
- B01D 15/40: using supercritical fluid as mobile phase or eluent
- C07C 39/19: containing carbon-to-carbon double bonds but no carbon-to-carbon triple bonds
- C07C 39/23: polycyclic, containing six-membered aromatic rings and other rings, with unsaturation outside the aromatic rings
- C07D 311/80: Dibenzopyrans; Hydrogenated dibenzopyrans
- C30B 7/00: Single-crystal growth from solutions using solvents which are liquid at normal temperature, e.g. aqueous solutions (from molten solvents C30B9/00; by normal or gradient freezing C30B11/00; under a protective fluid C30B27/00)
- C30B 29/54: Organic compounds
- B01D 9/00: Crystallisation (crystallisation directly from the vapour phase B01D7/02; making single crystals C30B {; crystallisation as part of the Bayer process also classified in C01F7/14})
- B01D: SEPARATION (separating solids from solids by wet methods B03B, B03D; by pneumatic jigs or tables B03B; by other dry methods B07; magnetic or electrostatic separation of solid materials from solid materials or fluids, separation by high-voltage electric fields B03C; centrifuges, vortex apparatus B04; presses per se for squeezing-out liquid from liquid-containing material B30B9/02; treatment of water C02F, e.g. softening by ion-exchange C02F1/42; {arrangements of air intake cleaners in gas turbine plants F02C7/05} ; arrangements or mounting of filters in air-conditioning, air-humidification or ventilation F24F13/28)
- C07C: ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07D: HETEROCYCLIC COMPOUNDS (macromolecular compounds C08)
- C30B: SINGLE-CRYSTAL GROWTH (by using ultra-high pressure, e.g. for the formation of diamonds, B01J3/06); UNIDIRECTIONAL SOLIDIFICATION OF EUTECTIC MATERIAL OR UNIDIRECTIONAL DEMIXING OF EUTECTOID MATERIAL; REFINING BY ZONE-MELTING OF MATERIAL (zone-refining of metals or alloys C22B); PRODUCTION OF A HOMOGENEOUS POLYCRYSTALLINE MATERIAL WITH DEFINED STRUCTURE (casting of metals, casting of other substances by the same processes or devices B22D; working of plastics B29; modifying the physical structure of metals or alloys C21D, C22F); SINGLE CRYSTALS OR HOMOGENEOUS POLYCRYSTALLINE MATERIAL WITH DEFINED STRUCTURE; AFTER-TREATMENT OF SINGLE CRYSTALS OR A HOMOGENEOUS POLYCRYSTALLINE MATERIAL WITH DEFINED STRUCTURE (for producing semiconductor devices or parts thereof H10); APPARATUS THEREFOR

## Abstract

This disclosure relates to techniques and methods to isolate and purify cannabinoids, such as CBDV, CBD, CBC, THCV, THC, CBN, CBG, CBDA, THCA, or CBGA. Evaporation and sonicating techniques are used to isolate and purify cannabinoids, such as CBDV, CBD, CBC, THCV, THC, CBN, CBG, CBDA, THCA, or CBGA. The resulting compounds find further use within the devices and compositions described herein as well as for preparative and analytical methods.

## Claims

### Claim 1

A method of purifying one or more cannabinoids from a plant material of genus cannabis, comprising:
adding the plant material of genus cannabis to ethanol;
sonicating the ethanol and plant material of genus cannabis at a temperature of between about −80 to 30 degrees Celsius;
dissolving cannabinoids in the ethanol to create a solution of cannabinoids;
physically separating the plant material of genus cannabis from the solution comprising cannabinoids; and
evaporating the ethanol from the solution at a pressure of less than 1 atmosphere.

### Claim 2 (depends on 1)

The method of claim 1, comprising sonicating the ethanol and plant material of genus cannabis at a temperature of between about −50 to 10 degrees Celsius.

### Claim 3 (depends on 2)

The method of claim 2, comprising sonicating the ethanol and plant material of genus cannabis at a temperature of between about −30 to −10 degrees Celsius.

### Claim 4 (depends on 1)

The method of claim 1, comprising evaporating the ethanol from the solution at a temperature of between about 20 to 60 degrees Celsius.

### Claim 5 (depends on 1)

The method of claim 1, comprising collecting a precipitated cannabinoid from within an ethanolic solution of cannabinoids.

### Claim 6 (depends on 5)

The method of claim 5, comprising dissolving the precipitated cannabinoid in an alcohol, creating a second solution, then recrystallizing the precipitated cannabinoid from the second solution.

### Claim 7 (depends on 6)

The method of claim 6, comprising evaporating alcohol from the second solution.

### Claim 8 (depends on 6)

The method of claim 6, wherein the alcohol is ethanol.