# US 11,027,151 B2 · Particle arc therapy > Agents: this data is available as JSON from the patentgrep API and MCP server — see https://patentgrep.com/llms.txt - Number: US 11,027,151 B2 - Document ID: US11027151B2 - Status: Granted - Kind: B2 - Application number: 16/083,354 - Filed: 2017-03-10 - Published: 2019-03-28 - Granted: 2021-06-08 - Earliest claimed: 2016-03-10 - Assignees: William Beaumont Hospital - Applicants: William Beaumont Hospital - Inventors: Xuanfeng Ding; Xiaoqiang Li; Di Yan - Web page: https://patentgrep.com/patent/US11027151B2 ## CPC - A61N 5/1043: {Scanning the radiation beam, e.g. spot scanning or raster scanning} - A61N 5/103: {Treatment planning systems} - A61N 5/1031: {using a specific method of dose optimization} - A61N 5/1047: {with movement of the radiation head during application of radiation, e.g. for intensity modulated arc therapy or IMAT} - A61N 5/1065: {Beam adjustment} - A61N 5/1069: {Target adjustment, e.g. moving the patient support} - A61N 5/1071: {for verifying the dose delivered by the treatment plan} - A61N 5/1082: {having multiple beam rotation axes} - A61N 5/1048: {Monitoring, verifying, controlling systems and methods} - A61N 2005/1087: {Ions; Protons} - A61N: ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY (measurement of bioelectric currents A61B; surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body A61B18/00; anaesthetic apparatus in general A61M; incandescent lamps H01K; infrared radiators for heating H05B) ## Abstract A method of delivering a particle beam at a target is disclosed. In implementations, the particle beam is delivered from an output device at a plurality of control points and the method comprises the step of delivering a substantially continuous particle beam about the plurality of control points. ## Claims ### Claim 1 A method of delivering a particle beam at a target, wherein the particle beam is delivered from an output device at a plurality of control points, the method comprising: delivering a substantially continuous particle beam about the plurality of control points; identifying an initial set of control points; providing a first group of optimized beams, wherein each optimized beam of the first group of optimized beams is configured to be output at a first control point and steered towards one or more energy layers that are associated with one or more monitor unit (MU) reducing energy layers among the first group of optimized beams associated with an MU that is lower than a threshold MU; providing a second group of optimized beams, each optimized beam of the second group of optimized beams configured to be output at the first control point and having a reduced number of energy layers; increasing a number of the initial control points; and maintaining a total number of energy layers equal to or less than a total number of energy layers associated with the initial control points during movement of the beam between the plurality of control points, wherein increasing the number of initial control points comprises adding one or more adjacent control points to each initial control point, the adjacent control point having a fraction number of the total energy layers or MU of the initial control point. ### Claim 2 (depends on 1) The method of claim 1, wherein increasing the number of control points comprises splitting each control point into at least two adjacent control points, wherein first and second adjacent control points each have a total number of energy layers being the same as a number of energy layers of the control point. ### Claim 3 (depends on 1) The method of claim 1, wherein increasing the number of initial control points comprises splitting each control point into a first adjacent control point and a second adjacent control point or three or more adjacent control point, the first and second adjacent control points having a total number of energy layers being less or greater than a number of energy layers of the control point. ### Claim 4 (depends on 1) The method of claim 1 further comprising: switching energy layers of at least one of the first group of optimized beams while adjusting at least two of the plurality of control points. ### Claim 5 (depends on 4) The method of claim 4 further comprising: delivering one or more beams to an energy layer at the at least two control points; and switching energy layers of at least one of the first group of optimized beams while adjusting at least two of the plurality of control points. ### Claim 6 (depends on 4) The method of claim 4 further comprising: delivering one or more beams to an energy layer at the at least two control points; and switching energy layers and adjusting the delivery of one or more spots associated with at least one of the energy layers. ### Claim 7 (depends on 1) The method of claim 1, further comprising: identifying a pre-selected control point sampling frequency and deriving the control points based on the pre-selected control point sampling frequency. ### Claim 8 (depends on 7) The method of claim 7, further comprising: pre-defining energy layers based on one or both of the control points and the control point sampling frequency; and sorting the energy layers. ### Claim 9 (depends on 8) The method of claim 8, further comprising: defining control point zones having a range of energy layers; assigning control points into the control point zones; and optimizing plan quality based on the control point zones and the control points. ### Claim 10 (depends on 1) The method of claim 1, further comprising: optimizing the delivery of the particle beam among the control points. ### Claim 11 (depends on 10) The method of claim 10, wherein the beam is directed at one or more energy layers among at least two adjacent control points, wherein the step of optimizing comprises: combining the at least two adjacent control points when one or both of (i) a difference between an energy level of one of the at least two adjacent control points and the energy level of the other of the at least two adjacent control points is beneath a threshold energy level difference amount; and (ii) a difference between a monitor unit of one of the at least two adjacent control points and the monitor unit of the other of the at least two adjacent control points is beneath a threshold monitor unit difference amount. ### Claim 12 (depends on 10) The method of claim 10, further comprising: optimizing the delivery by utilizing at least one of a (i) a spot reduction mechanism to remove one or more spots about target that have a MU at or below a MU threshold (ii) an energy layer reduction to remove one or more energy layers about target, that have a MU at or below a MU threshold, (iii) a control point re-sampling, (iv) energy layer re-distribution among the control points, (v) a spot delivery sequence re-distribution or re-organization or a combination thereof. ### Claim 13 (depends on 12) The method of claim 12, wherein the MU threshold is defined as being equal to or less than the bottom ten percent (10%) of one, some or all of (i) spot MUs in a plan; (ii) energy layers; (iii) impact angles; and (iv) a combination thereof. ### Claim 14 (depends on 12) The method of claim 12, wherein the spot reduction mechanism removes the low MU spots or lines sequentially, simultaneously or randomly during the step of optimizing such that it removes an amount equal to or less than ten percent (10%) of such spots after energy layer filtration or integrated with the energy layer filtration. ### Claim 15 (depends on 10) The method of claim 10, further comprising: further optimizing the delivery by again utilizing at least one of a (i) a spot reduction mechanism to remove one or more spots about target that have a MU at or below a MU threshold (ii) an energy layer reduction to remove one or more energy layers about target, that have a MU at or below a MU threshold, (iii) a control point re-sampling, (iv) energy layer re-distribution among the control points, (v) a spot delivery sequence re-distribution or re-organization or a combination thereof. ### Claim 16 (depends on 10) The method of claim 10, further comprising: optimizing the delivery by utilizing a spot reduction mechanism to remove one or more spots about the target that have a MU at or below a MU threshold. ### Claim 17 (depends on 10) The method of claim 10, further comprising: optimizing the delivery by utilizing an energy layer reduction to remove one or more energy layers about the target that have a MU at or below a MU threshold. ### Claim 18 (depends on 10) The method of claim 10, further comprising: optimizing the delivery by utilizing a control point re-sampling. ### Claim 19 (depends on 10) The method of claim 10, further comprising: performing a control point re-sampling. ### Claim 20 (depends on 10) The method of claim 10, further comprising: performing an energy layer re-distribution among the control points. ### Claim 21 (depends on 10) The method of claim 10, further comprising: performing a spot delivery sequence re-distribution or re-organization or a combination thereof. ### Claim 22 (depends on 10) The method of claim 10, wherein the step of delivering the particle beam includes the sub-step of compensating for one or both of sagging and iso-shift using a magnet to adjust a center particle beam position. ### Claim 23 (depends on 22) The method of claim 22, wherein the compensating step includes using a look up table to identify one or more of the following (i) an appropriate magnet coil current; (ii) an ionizing chamber signal position; (iii) a gantry angle; and (iv) a combination thereof. ### Claim 24 (depends on 1) The method of claim 1, wherein the method of delivery is selected by a user among a plurality of pre-generated plans. ### Claim 25 (depends on 24) The method of claim 24, wherein the plurality of pre-generated plans are generated based at least in part on variations to different plan parameters, plan qualities and delivery efficiency. ### Claim 26 (depends on 24) The method of claim 24, wherein the plurality of pre-generated plans are generated based at least in part on an objective value of each plan, each individual objective function, or delivery time for different machines or parameters. ### Claim 27 (depends on 1) The method of claim 1, wherein the control points are adjusted via a gantry. ### Claim 28 (depends on 1) The method of claim 1, wherein the target relates to a patient, and wherein the control points are adjusted via adjusting a position of the patient. ### Claim 29 (depends on 28) The method of claim 28, wherein the patient position is adjusted by means of a couch or a chair. ### Claim 30 (depends on 1) The method of claim 1, wherein the control points are adjusted by at least one of an adjustment of (i) a gantry, (ii) a couch, or (iii) a combination of the foregoing. ### Claim 31 (depends on 1) The method of claim 1, further comprising: simultaneously acquiring an image while delivering the substantially continuous particle beam. ### Claim 32 (depends on 1) The method of claim 1, wherein the target relates to a patient, and wherein the particle beam is delivered in one or more of (i) a non-coplanar manner, and (ii) a non iso-centric manner, in each case with respect to the patient and the delivery means. ### Claim 33 A method of delivering a particle beam at a target, wherein the particle beam is delivered from an output device at a plurality of control points, the method comprising: delivering a substantially continuous particle beam about the plurality of control points; pre-defining energy layers based on one or both of the control points and a control point sampling frequency; and sorting the energy layers. ### Claim 34 (depends on 33) The method of claim 33, further comprising: defining control point zones having a range of energy layers; assigning control points into the control point zones; and optimizing plan quality based on the control point zones and the control points. ### Claim 35 A method of delivering a particle beam at a target, wherein the particle beam is delivered from an output device at a plurality of control points, the method comprising: delivering a substantially continuous particle beam about the plurality of control points; optimizing the delivery of the particle beam among the control points by utilizing at least one of a (i) a spot reduction mechanism to remove one or more spots about target that have a MU at or below a MU threshold, (ii) an energy layer reduction to remove one or more energy layers about target, that have a MU at or below a MU threshold, (iii) a control point re-sampling, (iv) energy layer re-distribution among the control points, (v) a spot delivery sequence re-distribution or re-organization or a combination thereof, wherein the MU threshold is defined as being equal to or less than the bottom ten percent (10%) of one, some or all of (i) spot MUs in a plan; (ii) energy layers; (iii) impact angles; and (iv) a combination thereof. ### Claim 36 A method of delivering a particle beam at a target, wherein the particle beam is delivered from an output device at a plurality of control points, the method comprising: delivering a substantially continuous particle beam about the plurality of control points; optimizing the delivery of the particle beam among the control points by utilizing at least one of a (i) a spot reduction mechanism to remove one or more spots about target that have a MU at or below a MU threshold, (ii) an energy layer reduction to remove one or more energy layers about target, that have a MU at or below a MU threshold, (iii) a control point re-sampling, (iv) energy layer re-distribution among the control points, (v) a spot delivery sequence re-distribution or re-organization or a combination thereof, wherein the spot reduction mechanism removes the low MU spots or lines sequentially, simultaneously or randomly during the step of optimizing such that it removes an amount equal to or less than ten percent (10%) of such spots after energy layer filtration or integrated with the energy layer filtration.