# US 11,027,145 B2 · Laser induced ballistic particle implantation technique

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- Number: US 11,027,145 B2
- Document ID: US11027145B2
- Status: Granted
- Kind: B2
- Application number: 16/220,505
- Filed: 2018-12-14
- Published: 2019-06-20
- Granted: 2021-06-08
- Earliest claimed: 2017-12-15
- Assignees: The Government of the United States of America, as represented by the Secretary of the Navy
- Applicants: The Government of the United States of America, as represented by the Secretary of the Navy
- Inventors: Bradley R. Ringeisen; Peter K. Wu
- Web page: https://patentgrep.com/patent/US11027145B2

## CPC

- A61N 5/062: {Photodynamic therapy, i.e. excitation of an agent}
- A61M 37/00: Other apparatus for introducing media into the body (for reproduction or fertilisation A61B17/425; apparatus for iontophoresis or cataphoresis A61N1/30); Percutany, i.e. introducing medicines into the body by diffusion through the skin (salt baths A61H33/04)
- A61B 5/00: Measuring for diagnostic purposes (radiation diagnosis A61B6/00; diagnosis by ultrasonic, sonic or infrasonic waves A61B8/00); Identification of persons
- A61B 5/14532: {for measuring glucose, e.g. by tissue impedance measurement}
- A61B 5/14542: {for measuring blood gases (A61B5/14551 takes precedence)}
- A61B 2562/0285: Nanoscale sensors
- A61N 5/067: using laser light
- A61N: ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY (measurement of bioelectric currents A61B; surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body A61B18/00; anaesthetic apparatus in general A61M; incandescent lamps H01K; infrared radiators for heating H05B)
- A61M: DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY (introducing media into or onto the bodies of animals A61D7/00; means for inserting tampons A61F13/26; devices for administering food or medicines orally A61J; containers for collecting, storing or administering blood or medical fluids A61J1/05); DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY (surgery A61B; chemical aspects of surgical articles A61L); DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR {(Electrotherapy, e.g. producing anaesthesia by the use of alternating or intermittent currents A61N1/36021)}
- A61B: DIAGNOSIS; SURGERY; IDENTIFICATION (usefulness limited to only animals A61D)

## Abstract

A method using a receiving substrate and a target substrate having a photon-transparent support, a photon absorbent interlayer coated on the support, and a tissue-implantable particle on top of the interlayer opposite to the support. A source of photon energy is directed through the transparent support so that the photon energy strikes the interlayer. A portion of the interlayer is energized by absorption of the photon energy. The energized interlayer causes a transfer of the particle across a gap between the target substrate and the receiving substrate and embedding of the particle into the receiving substrate.

## Claims

### Claim 1

A method comprising:
providing a receiving substrate;
wherein the receiving substrate comprises living tissue, a living organism, or a living human;
providing a target substrate comprising a photon-transparent support, a photon absorbent interlayer coated on the support, and a tissue-implantable particle on top of the interlayer opposite to the support;
wherein the particle comprises an integrated circuit;
providing a source of photon energy; and
directing the photon energy through the transparent support so that the photon energy strikes the interlayer;
wherein a portion of the interlayer is energized by absorption of the photon energy; and
wherein the energized interlayer causes a transfer of the particle across a gap between the target substrate and the receiving substrate and embedding of the particle into the receiving substrate.

### Claim 2 (depends on 1)

The method of claim 1, wherein the photon transparent support comprises quartz, sapphire, or amorphous silica.

### Claim 3 (depends on 1)

The method of claim 1, wherein the photon absorbent interlayer comprises titania, gold, gold alloy, platinum, or titanium.

### Claim 4 (depends on 1)

The method of claim 1, wherein the photon absorbent interlayer is 5-100 nm thick.

### Claim 5 (depends on 1)

The method of claim 1, wherein the particle has a diameter of no more than 500 microns.

### Claim 6 (depends on 1)

The method of claim 1, wherein the particle has a diameter of no more than 50 microns.