# US 11,027,143 B2 · System and methods for treating cancer cells with alternating polarity magnetic fields

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- Number: US 11,027,143 B2
- Document ID: US11027143B2
- Status: Granted
- Kind: B2
- Application number: 16/784,239
- Filed: 2020-02-06
- Published: 2020-08-13
- Granted: 2021-06-08
- Earliest claimed: 2019-02-07
- Applicants: Vivek K. Sharma
- Inventors: Vivek K. Sharma
- Web page: https://patentgrep.com/patent/US11027143B2

## CPC

- A61N 2/004: {specially adapted for a specific therapy}
- A61J 1/2006: {Piercing means}
- A61J 1/2037: {having valve means}
- A61J 1/2072: {for internal venting}
- A61K 31/00: Medicinal preparations containing organic active ingredients
- A61K 45/06: Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
- A61M 5/19: having more than one chamber
- A61M 39/14: for connecting tubes having sealed ends {(needle sets A61M5/162; having valves closing automatically on disconnection of line A61M39/26)}
- A61M 39/24: Check- or non-return valves
- A61N 2/002: {in combination with another treatment}
- A61N 2/02: using magnetic fields produced by coils, including single turn loops or electromagnets (A61N2/12 takes precedence)
- A61P 35/00: Antineoplastic agents
- G02F 1/017: Structures with periodic or quasi periodic potential variation, e.g. superlattices, quantum wells
- G02F 1/025: in an optical waveguide structure (G02F1/017, {G02F1/2257} take precedence)
- A61B 6/032: {Transmission computed tomography [CT]}
- A61B 6/037: {Emission tomography}
- A61B 6/50: specially adapted for specific body parts; specially adapted for specific clinical applications
- A61N 2/06: using magnetic fields produced by permanent magnets (A61N2/12 takes precedence)
- A61N: ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY (measurement of bioelectric currents A61B; surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body A61B18/00; anaesthetic apparatus in general A61M; incandescent lamps H01K; infrared radiators for heating H05B)
- A61J: CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
- A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D)
- A61M: DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY (introducing media into or onto the bodies of animals A61D7/00; means for inserting tampons A61F13/26; devices for administering food or medicines orally A61J; containers for collecting, storing or administering blood or medical fluids A61J1/05); DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY (surgery A61B; chemical aspects of surgical articles A61L); DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR {(Electrotherapy, e.g. producing anaesthesia by the use of alternating or intermittent currents A61N1/36021)}
- A61P: SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- G02F: OPTICAL DEVICES OR ARRANGEMENTS FOR THE CONTROL OF LIGHT BY MODIFICATION OF THE OPTICAL PROPERTIES OF THE MEDIA OF THE ELEMENTS INVOLVED THEREIN; NON-LINEAR OPTICS; FREQUENCY-CHANGING OF LIGHT; OPTICAL LOGIC ELEMENTS; OPTICAL ANALOGUE/DIGITAL CONVERTERS
- A61B: DIAGNOSIS; SURGERY; IDENTIFICATION (usefulness limited to only animals A61D)

## Abstract

Systems and method for destroying or inhibiting cancer cells and other rapidly-dividing cells include coupling an alternating polarity (AP) magnetic field generator to a target body area and applying an AP magnetic field having a frequency of 0.5-500 kHz and a field strength of 0.5-5 mT to the target body area to achieve a desired inhibiting effect on cancer cells or other rapidly-dividing cells. Treatments provided by the system may be co-administered with an anti-cancer drug such as a chemotherapy drug, a hormone therapy drug, targeted therapy drugs, immunotherapy drugs, or an angiogenesis inhibitor drug.

## Claims

### Claim 1

A method of treating cancer cells in a target body area of a patient, comprising:
providing a magnetic field therapy system comprising:
an alternating polarity (AP) magnetic field generator;
one or more AP electromagnetic coils coupled to the AP magnetic field generator, wherein the one or more AP electromagnetic coils are energized by an electrical signal from the AP magnetic field generator to generate an AP magnetic field having at least a first frequency and a first field strength; and
a controller to control at least one of the first frequency and the first field strength of the AP magnetic field generated by the one or more AP electromagnetic coils;
coupling the one or more AP electromagnetic coils to the target body area;
generating an AP magnetic field having a first frequency of 0.5-400 kHz and a first field strength of 0.2-5 mT using the one or more AP electromagnetic coils;
applying the generated AP magnetic field to the target body area using the one or more AP electromagnetic coils, wherein the AP magnetic field selectively affects the cancer cells to prevent metastasis of the cancer cells, while leaving non-cancer cells substantially unharmed; and
treating the patient during at least a portion of the step of applying the generated AP magnetic field to the target body area with an immunotherapy.

### Claim 2 (depends on 1)

The method of claim 1, wherein coupling the one or more AP electromagnetic coils to the target body area comprises using a retaining element to maintain the one or more AP electromagnetic coils in close proximity to the target body area, and wherein the retaining element is selected from a garment and a bandage.

### Claim 3 (depends on 2)

The method of claim 2, wherein the cancer cells comprise at least one of:
breast cancer, and the retaining element is a wearable garment selected from a bra, a shirt, or a vest;
lung cancer, lung carcinoid tumors, thymic malignancies, tracheal tumors, pancreatic cancer, liver cancer, stomach cancer, kidney cancer, ovarian cancer, colon cancer and rectal cancer, and the retaining element is a wearable garment selected from a bra, a shirt, a vest, and a jacket;
a lower-body cancer selected from prostate cancer, ovarian cancer, colon cancer, and rectal cancer, and the retaining element is an undergarment;
skin cancer, and the retaining element is one of an adhesive bandage and a non-adhesive bandage; and
one of a throat, thyroid, mouth, nose, and salivary gland cancer, and the retaining element is selected from a neck cuff, a neck collar, and a scarf.

### Claim 4 (depends on 1)

The method of claim 1, further comprising:
administering to the patient at least one additional anti-cancer therapy selected from a radiation therapy, a chemotherapy drug, a hormone therapy drug, a targeted therapy drug, an angiogenesis inhibitor drug, and tumor treatment field therapy.

### Claim 5 (depends on 4)

The method of claim 4, wherein administering to the patient an at least one additional anti-cancer therapy comprises administering the at least one additional anti-cancer therapy at one or more of:
a lower dosage than a dosage that would be administered in the absence of applying the generated AP magnetic field to the target body area; and
a reduced dosing frequency compared to the frequency at which the at least one additional anti-cancer therapy would be administered in the absence of applying the generated AP magnetic field to the target body area.

### Claim 6 (depends on 1)

The method of claim 1, wherein applying the AP magnetic field reduces a side effect of the immunotherapy.

### Claim 7 (depends on 1)

The method of claim 1 wherein coupling the one or more AP electromagnetic coils to the target body area comprises coupling a plurality of AP electromagnetic coils to the target body area, wherein each coil in said plurality of coils is oriented so as to apply a desired AP magnetic field distribution in the target body area.

### Claim 8 (depends on 1)

The method of claim 1, wherein coupling the one or more AP electromagnetic coils to the target body area comprises coupling a plurality of AP electromagnetic coils to the target body area, the method further comprising:
selecting one or more coils from the plurality of coils to activate to apply the AP magnetic field based on one of
1) the result of an imaging procedure selected from an MRI scan, a CT scan, a PET scan, and an X-ray, and
2) a pathological analysis of the cancer cells selected from a microscopic analysis of a cell biopsy and a chemical test performed on the cancer cells;
and wherein applying the generated AP magnetic field to the target body area comprises applying the generated AP magnetic field to the target body area using the selected one or more AP electromagnetic coils.

### Claim 9 (depends on 1)

The method of claim 1, wherein generating an AP magnetic field comprises one or more of:
generating an AP magnetic field continuously for a first treatment period;
generating an AP magnetic field intermittently for a second treatment period in alternating on-time periods, followed by off time periods in which an AP magnetic field is not generated;
generating an AP magnetic field intermittently for one or more circadian treatment periods based on circadian rhythms of the patient; and
generating an AP magnetic field intermittently for one or more third treatment periods at defined times of day.

### Claim 10 (depends on 1)

The method of claim 1, wherein generating an AP magnetic field comprises one or more of:
generating an AP magnetic field having a single first frequency of 0.5-400 kHz;
generating an AP magnetic field for a defined time period having a first frequency of 0.5-400 kHz that varies in a defined pattern;
generating an AP magnetic field having multiple simultaneous frequencies, wherein each of the multiple simultaneous frequencies is a frequency within the range of 0.5-400 kHz.

### Claim 11 (depends on 10)

The method of claim 10, wherein generating an AP magnetic field for a defined time period having a first frequency of 0.5-400 kHz that varies in a defined pattern comprises at least one of:
generating an AP magnetic field in which the first frequency changes randomly at a defined rate;
generating an AP magnetic field in which the first frequency varies in a Gaussian distribution in one or more sub-ranges within the range of 0.5-400 kHz;
generating an AP magnetic field in which the first frequency varies in a non-Gaussian distribution in one or more sub-ranges within the range of 0.5-400 kHz.

### Claim 12 (depends on 1)

The method of claim 1, wherein applying the generated AP magnetic field to the target body area is performed one of:
prior to a surgical procedure to treat the patient;
during a surgical procedure to treat the patient;
after a surgical procedure to treat the patient;
prior to a radiation procedure to treat the patient;
during a radiation procedure to treat the patient; and
after a radiation procedure to treat the patient.

### Claim 13 (depends on 1)

The method of claim 1, further comprising:
shielding at least one non-target body area from exposure to the AP magnetic field during the step of applying the generated AP magnetic field to the target body area.

### Claim 14 (depends on 1)

The method of claim 1, wherein generating an AP magnetic field comprises generating an AP magnetic field having a first frequency within the range of 25-400 kHz.

### Claim 15 (depends on 1)

The method of claim 1, wherein generating an AP magnetic field comprises generating an AP magnetic field having a first frequency within the range of 50-300 kHz and a first field strength within the range of 0.2-2 mT.

### Claim 16 (depends on 1)

The method of claim 1, wherein generating an AP magnetic field comprises generating an AP magnetic field having a first frequency within the range of 0.5-250 kHz and a first field strength within the range of 0.2-2 mT.

### Claim 17 (depends on 1)

The method of claim 1, wherein generating an AP magnetic field comprises generating an AP magnetic field having a first frequency within the range of 0.5-150 kHz and a first field strength within the range of 0.2-2 mT.

### Claim 18 (depends on 1)

The method of claim 1, wherein treating the patient with an immunotherapy comprises administering the immunotherapy at one or more of:
a lower dosage than a dosage that would be administered in the absence of applying the generated AP magnetic field to the target body area; and
a reduced dosing frequency compared to the frequency at which the immunotherapy would be administered in the absence of applying the generated AP magnetic field to the target body area.

### Claim 19 (depends on 1)

The method of claim 1, wherein generating an AP magnetic field comprises generating an AP magnetic field in a burst mode defined by alternating on-time and off-time periods repeated at a second frequency, wherein each of the on-time periods of the second frequency comprises an AP magnetic field having the first frequency of 0.5-400 kHz.

### Claim 20 (depends on 1)

The method of claim 1, wherein generating an AP magnetic field comprises generating an AP magnetic field having a first waveform, the method further comprising:
performing amplitude modulation of the first waveform of the generated AP magnetic field prior to the step of applying the generated AP magnetic field to the target body area.