# US 11,027,131 B2 · Use of a new stimulation design to treat neurological disorders

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- Number: US 11,027,131 B2
- Document ID: US11027131B2
- Status: Granted
- Kind: B2
- Application number: 16/022,254
- Filed: 2018-06-28
- Published: 2018-10-25
- Granted: 2021-06-08
- Earliest claimed: 2010-08-30
- Applicants: Dirk De Ridder
- Inventors: Dirk De Ridder
- Web page: https://patentgrep.com/patent/US11027131B2

## CPC

- A61N 1/36196: {Frequency modulation}
- A61B 5/37: Intracranial electroencephalography [IC-EEG], e.g. electrocorticography [ECoG]
- A61B 5/372: Analysis of electroencephalograms
- A61B 5/4812: {Detecting sleep stages or cycles}
- A61N 1/36082: {Cognitive or psychiatric applications, e.g. dementia or Alzheimer's disease}
- A61N 1/36171: {Frequency}
- A61N 1/378: Electrical supply
- A61N 1/0529: {Electrodes for brain stimulation}
- A61N 1/0551: {Spinal or peripheral nerve electrodes}
- A61N 1/36075: {Headache or migraine}
- A61N 1/361: {Phantom sensations, e.g. tinnitus}
- A61N: ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY (measurement of bioelectric currents A61B; surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body A61B18/00; anaesthetic apparatus in general A61M; incandescent lamps H01K; infrared radiators for heating H05B)
- A61B: DIAGNOSIS; SURGERY; IDENTIFICATION (usefulness limited to only animals A61D)

## Abstract

The method and system described herein relate to stimulating nerve tissue using a pulse generator. A stimulus is created that comprises a signal that is produced from a frequency spectrum having a power spectral density per unit of bandwidth proportional to 1/fβ, wherein β is excludes 0. The stimulus is provided from the pulse generator to at least one stimulation lead; and applied to nerve tissue via one or several electrodes.

## Claims

### Claim 1

An implantable pulse generator (IPG) for neurostimulation of a patient, comprising:
a battery for powering the IPG;
a processor for controlling the IPG according to executable instructions;
memory for storing executable instructions and data; and pulse generating circuitry for generating electrical pulses for stimulation of nerve tissue of the patient;
wherein (1) the processor controls pulse generation operations of the IPG according to one or more stimulation programs defined by a clinician of the patient, (2) IPG is programmable by the clinician to select from multiple stimulation patterns for pulse generation including a noise stimulation pattern, (3) the IPG is programmed to retrieve a parameter β from a respective stimulation program defined for the noise stimulation pattern to generate electrical pulses generally exhibiting amplitude variations for a noise power density profile of 1/f∧β where f represents frequency, and (4) the parameter β for the respective stimulation program is selectable by the clinician from a range of values including β=1, β=2, and multiple values therebetween.

### Claim 2 (depends on 1)

The IPG of claim 1 wherein the IPG is programmed to apply a first stimulation program during an active state of the patient and is programmed to apply a second stimulation program during a sleep state of the patient, wherein the first stimulation program and the second stimulation program include different β values for respective noise stimulation patterns.

### Claim 3 (depends on 1)

The IPG of claim 1 wherein the IPG is programmed to retrieve a second parameter from a respective stimulation program defined for the noise stimulation pattern to generate electrical pulses such that a noise power density profile of the respective stimulation program exhibits a peak at a frequency defined by the second parameter.

### Claim 4 (depends on 3)

The IPG of claim 3 wherein the IPG is adapted to communicate with an external controller device to receive a value for the second parameter, wherein the external controller device measures neurological signals of the patient to select the value for the second parameter.

### Claim 5 (depends on 4)

The IPG of claim 4 wherein the neurological signals are EGG signals.

### Claim 6 (depends on 1)

The IPG of claim 1 wherein the multiple stimulation patterns includes burst stimulation, wherein burst stimulation includes a plurality of groups of multiple pulses with adjacent groups being separated by respective quiescent periods.

### Claim 7 (depends on 1)

The IPG of claim 1 wherein the multiple stimulation patterns includes tonic stimulation.

### Claim 8 (depends on 1)

The IPG of claim 1 wherein the IPG is programmable to apply a respective noise stimulation pattern to multiple electrodes.

### Claim 9 (depends on 8)

The IPG of claim 8 wherein the IPG applies pulses by sequentially cycling through the multiple electrodes.

### Claim 10 (depends on 8)

The IPG of claim 8 wherein the IPG applies pulses by randomly transitioning between the multiple electrodes.