# US 11,027,128 B2 · Device for non-invasive electrical stimulation of the spinal cord

> Agents: this data is available as JSON from the patentgrep API and MCP server — see https://patentgrep.com/llms.txt

- Number: US 11,027,128 B2
- Document ID: US11027128B2
- Status: Granted
- Kind: B2
- Application number: 16/067,173
- Filed: 2016-11-29
- Published: 2019-01-24
- Granted: 2021-06-08
- Earliest claimed: 2015-12-29
- Assignees: Cosyma Ltd; The Regents of the University of California
- Applicants: Cosyma Ltd; The Regents of the University of California
- Inventors: Yuri Petrovich Gerasimenko; Alexandr Alekseevich Grishin; Tatiana Romulievna Moshonkina
- Web page: https://patentgrep.com/patent/US11027128B2

## CPC

- A61N 1/36034: {specified by the stimulation parameters}
- A61N 1/36003: {of motor muscles, e.g. for walking assistance}
- A61N: ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY (measurement of bioelectric currents A61B; surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body A61B18/00; anaesthetic apparatus in general A61M; incandescent lamps H01K; infrared radiators for heating H05B)

## Abstract

A device for the noninvasive stimulation of the spinal cord, intended for carrying out diagnostic tests and physiotherapy. A spinal cord electrostimulator includes five stimulation channels with an electrode system, each of the channels includes connected in series a voltage converter, a current generator and an output signal generator and it is configured to be able to generate the following rectangular pulses: rhythmic modulated bipolar, rhythmic modulated monopolar, rhythmic non-modulated monopolar, single non-modulated monopolar. The inputs of each of the channels are coupled to a microcontroller, which is connected to an indication unit, a control unit and a radio module. The microcontroller is configured to trigger at least one said channel, to select a triggering mode independently for each of the channels, to control each of said channels with parameters of the pulses and vary said parameters depending on a degree of damage to a spinal segment.

## Claims

### Claim 1

A device for non-invasive stimulation of the spinal cord of a patient comprising
an electrostimulator located in close proximity to the patient, the electrostimulator comprising five stimulation channels and an electrode system,
wherein each of said five stimulation channels of the electrostimulator is connected to electrodes of the electrode system via wires, the electrodes being attached epicutaneously paraspine in a neck, thoracic, lumbar region or in a coccyx to stimulate the spinal cord and/or paravertebral in a projection of roots of the spinal cord to stimulate the roots of the spinal cord at least on one region of the spinal cord,
wherein each of said stimulation channels includes a series-connected voltage converter, a current generator and an output signal shaper; and
wherein each of said stimulation channels is configured to be able to generate at least one pulse selected from the group consisting of:
rectangular single monopolar pulse for muscle activation,
rectangular rhythmic monopolar pulses,
rectangular rhythmic modulated monopolar pulses,
rectangular rhythmic modulated bipolar pulses to trigger a locomotor response or trigger a tonic response in muscles, and
combinations thereof
with a stimulation frequency in the range of 1-99 Hz, with a current amplitude from 1 mA to 300 mA and with a modulation frequency from 4 kHz to 10 kHz;
wherein inputs of each of said stimulation channels are connected to a microcontroller, connected to an indication unit, a control unit and a radio module;
wherein said microcontroller is configured
to trigger at least one of each said stimulation channels;
to select a triggering mode independently for each of said stimulation channels; and
to control each of the stimulation channels with parameters of the generated pulses, the parameters selected from the following:
type of the pulses;
the stimulation frequency, which may change in steps of 1 Hz or higher;
the modulation frequency, which may change in steps of 1 kHz or higher;
the current amplitude, which may change in steps of 1 mA or higher; and
the pulse duration, which may change in steps of 0.1 ms or higher.

### Claim 2 (depends on 1)

The electrostimulator of claim 1, wherein the microcontroller is configured to select the triggering mode between a single-time mode with a passive phase of depolarization and a continuous mode with active type of a phase of depolarization.

### Claim 3 (depends on 1)

The electrostimulator of claim 1, wherein it is synchronized with external devices that have sync input, for example, with devices for registration of the caused motive answer as goniometers.

### Claim 4 (depends on 1)

The electrostimulator of claim 1, wherein it is further connected to a computer.

### Claim 5 (depends on 4)

The electrostimulator of claim 4, wherein triggering of at least one of each said stimulation channels, selection of the triggering mode independently for each of said stimulation channels, and control of each of said stimulation channels by parameters of the generated pulses are carried out by means of the computer.

### Claim 6 (depends on 4)

The electrostimulator of claim 4, wherein triggering of at least one of each said stimulation channels, selection of the triggering mode independently for each of said stimulation channels, and control of each of said stimulation channels by the parameters of the rhythmic pulses are carried out by means of the computer, the control unit and the indication unit.

### Claim 7 (depends on 4)

The electrostimulator of claim 4, wherein triggering of at least one of each said stimulation channel, selection of the triggering mode independently for each of said stimulation channels, and control of each of said stimulation channels by the parameters of the rhythmic pulses are carried out by means of the control unit and the indication unit.