# US 11,027,082 B2 · Methods and systems to estimate compliance of a patient circuit in the presence of leak

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- Number: US 11,027,082 B2
- Document ID: US11027082B2
- Status: Granted
- Kind: B2
- Application number: 15/762,883
- Filed: 2016-09-26
- Published: 2018-09-13
- Granted: 2021-06-08
- Earliest claimed: 2015-09-28
- Assignees: Koninklijke Philps N.V.
- Applicants: Koninklijke Philips N.V.
- Inventors: Michael Anthony Borrello
- Web page: https://patentgrep.com/patent/US11027082B2

## CPC

- A61M 16/026: {specially adapted for predicting, e.g. for determining an information representative of a flow limitation during a ventilation cycle by using a root square technique or a regression analysis}
- A61M 16/0003: {Accessories therefor, e.g. sensors, vibrators, negative pressure}
- A61M 16/024: {including calculation means, e.g. using a processor}
- A61M 16/0875: {Connecting tubes}
- G16H 50/20: for computer-aided diagnosis, e.g. based on medical expert systems
- A61M 16/0051: {with alarm devices}
- A61M 16/0066: {Blowers or centrifugal pumps}
- A61M 16/06: Respiratory or anaesthetic masks
- A61M 16/08: Bellows; Connecting tubes {(having means for taking samples G01N1/22); Water traps; Patient circuits}
- A61M 16/0883: {Circuit type}
- A61M 16/205: {used for exhalation control}
- A61M 2016/0027: {pressure meter}
- A61M 2016/0033: {electrical}
- A61M 2016/0042: {in the expiratory circuit}
- A61M 2205/15: Detection of leaks
- A61M 2205/3344: Measuring or controlling pressure at the body treatment site
- A61M 2205/70: with testing or calibration facilities
- A61M: DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY (introducing media into or onto the bodies of animals A61D7/00; means for inserting tampons A61F13/26; devices for administering food or medicines orally A61J; containers for collecting, storing or administering blood or medical fluids A61J1/05); DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY (surgery A61B; chemical aspects of surgical articles A61L); DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR {(Electrotherapy, e.g. producing anaesthesia by the use of alternating or intermittent currents A61N1/36021)}
- G16H: HEALTHCARE INFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR THE HANDLING OR PROCESSING OF MEDICAL OR HEALTHCARE DATA

## Abstract

A method (200) for determining compliance of a connecting circuit in a non-invasive ventilator system. The method includes the steps of: (i) providing (210) a non-invasive ventilator system, the system having a flow or pressure controller; (ii) generating (220) a test signal for the flow or pressure controller; (iii) exciting (230) the flow or pressure controller with the generated test signal for a predetermined time period; (iv) obtaining (240), during the excitation of the flow or pressure controller, one or more measurements of the non-invasive ventilator system; (v) determining (250) a vector of the obtained measurements; and (vi) processing (260) the vector to determine an estimate of a physical parameter of the circuit.

## Claims

### Claim 1

A method for determining compliance of a connecting circuit in a non-invasive ventilator system, the method comprising the steps of:
providing a non-invasive ventilator system, the system comprising a mask configured to provide gas to a user, a flow or pressure controller and further comprising a low frequency, high cutoff, low pass filter;
generating a test signal by filtering white noise through the low frequency, high cutoff, low pass filter;
exciting the flow or pressure controller with the generated test signal for a predetermined time period, wherein excitation occurs over a series of increasing bias flows;
obtaining, during the excitation of the pressure or flow controller, a measurement of at least one of a gas pressure or flow rate of the non-invasive ventilator system;
determining a vector of pressure of the obtained measurement; and
determining, using the determined pressure vector, a parameter of a pressure flow model to indicate compliance of the connecting circuit in the non-invasive ventilator system.

### Claim 2 (depends on 1)

The method of claim 1, wherein the measurement is proximal pressure or blower flow.

### Claim 3 (depends on 1)

The method of claim 1, further comprising the steps of:
averaging the one or more measurements obtained during a first subset of the predetermined time period;
analyzing the average to determine whether a patient port of the non-invasive ventilator system was blocked and/or if the leak was insufficient during the obtaining step; and
proceeding to said determining a vector of the obtained measurement step only if the patient port was blocked and/or the leak was sufficient.

### Claim 4 (depends on 1)

The method of claim 1, wherein the generated test signal is offset by a bias.

### Claim 5 (depends on 1)

The method of claim 1, wherein the vector is determined using a Moore-Penrose pseudo inverse method.

### Claim 6 (depends on 1)

The method of claim 1, further comprising the step of comparing the determined physical parameter estimate measurement to a predetermined range of acceptance.

### Claim 7 (depends on 6)

The method of claim 6, wherein the determined physical parameter estimate is utilized by the non-invasive ventilator system only if the determined physical parameter estimate is within the predetermined range of acceptance.

### Claim 8

A non-invasive ventilator system, comprising:
a remote ventilator component configured to generate a gas source;
a user interface comprising a mask configured to provide gas to a user;
a connecting circuit configured to connect the remote ventilator component to the user interface;
at least one sensor configured to measure at least one of gas flow or pressure;
a low frequency, high cutoff, low pass pressure filter, wherein a pressure test signal is filtered; and
a controller, the controller configured to generate the pressure test signal by filtering white noise through the low frequency, high cutoff, low pass filter; excite a flow source of the remote ventilator component with the generated pressure test signal for a predetermined time period, wherein excitation occurs over a series of increasing bias flows; obtain a measurement of at least one of a gas pressure or flow rate from the at least one sensor of the system; determine a vector of pressure of the obtained measurement; and determine, using the determined pressure vector, a parameter of a pressure flow model to indicate a compliance of a connecting circuit in the non-invasive ventilator system.

### Claim 9 (depends on 8)

The non-invasive ventilator system of claim 8, wherein the measurement is proximal pressure.