# US 11,027,072 B2 · Emergency devices > Agents: this data is available as JSON from the patentgrep API and MCP server — see https://patentgrep.com/llms.txt - Number: US 11,027,072 B2 - Document ID: US11027072B2 - Status: Granted - Kind: B2 - Application number: 16/592,319 - Filed: 2019-10-03 - Published: 2020-04-23 - Granted: 2021-06-08 - Earliest claimed: 2018-05-25 - Assignees: Adamis Pharmaceuticals Corporation - Applicants: Adamis Pharmaceuticals Corporation - Inventors: Mark J. Flather; Karen K. Daniels; Thomas Moll; Ronald B. Moss; Dennis J. Carlo - Web page: https://patentgrep.com/patent/US11027072B2 ## CPC - A61M 5/31535: {Means improving security or handling thereof, e.g. blocking means, means preventing insufficient dosing, means allowing correction of overset dose} - A61K 31/485: Morphinan derivatives, e.g. morphine, codeine - A61M 5/31591: {Single dose, i.e. individually set dose administered only once from the same medicament reservoir, e.g. including single stroke limiting means} - A61M 5/3157: {Means providing feedback signals when administration is completed (A61M5/20 takes precedence)} - A61M 5/3202: {Devices for protection of the needle before use, e.g. caps (A61M5/50 takes precedence; protectors for sharps A61B50/3001)} - A61M 2005/5033: {by use of an intermediate blocking member positioned between the syringe barrel and the piston rod to prevent retraction of the latter, e.g. toothed clip placed on the piston rod} - A61M 2205/6081: Colour codes - A61M 2209/06: Packaging for specific medical equipment - A61M: DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY (introducing media into or onto the bodies of animals A61D7/00; means for inserting tampons A61F13/26; devices for administering food or medicines orally A61J; containers for collecting, storing or administering blood or medical fluids A61J1/05); DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY (surgery A61B; chemical aspects of surgical articles A61L); DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR {(Electrotherapy, e.g. producing anaesthesia by the use of alternating or intermittent currents A61N1/36021)} - A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D) ## Abstract Described herein are syringe devices comprising a syringe including a therapeutic dose of at least one drug to be used in a drug or substance overdose. Also provided herein are compositions and methods of treating opioid overdose using high dose naloxone. ## Claims ### Claim 1 A high dose naloxone composition including naloxone at a dose greater than or equal to about 5 mg configured for administration, wherein Cmax is between 15 ng/mL to 24 ng/mL and the administration is an injection. ### Claim 2 (depends on 1) The high dose naloxone composition of claim 1, wherein the dose is greater than about 10 mg. ### Claim 3 (depends on 1) The high dose naloxone composition of claim 1, including naloxone hydrochloride at a dose of 5 mg/0.5 mL. ### Claim 4 (depends on 3) The high dose naloxone composition of claim 3, wherein the composition is configured for a single administration. ### Claim 5 (depends on 4) The high dose naloxone composition of claim 4, wherein the administration is using an injection device. ### Claim 6 (depends on 1) The high dose naloxone composition of claim 1, wherein the composition is aqueous. ### Claim 7 (depends on 1) The high dose naloxone composition of claim 1, wherein the Cmax is 15.8 ng/mL. ### Claim 8 (depends on 1) The high dose naloxone composition of claim 1, wherein the Cmax is 17.2 ng/mL. ### Claim 9 A high dose naloxone composition including naloxone at a dose greater than about 5 mg configured for administration, wherein the AUC0-0.04 h is between 0.01 h*ng/mL and 0.1 h*ng/mL and the administration is an injection. ### Claim 10 (depends on 9) The high dose naloxone composition of claim 9, including naloxone hydrochloride at a dose of 5 mg/0.5 mL. ### Claim 11 (depends on 10) The high dose naloxone composition of claim 10, wherein the composition is configured for a single administration. ### Claim 12 (depends on 11) The high dose naloxone composition of claim 11, wherein the administration is using an injection device. ### Claim 13 (depends on 9) The high dose naloxone composition of claim 9, wherein the AUC0-0.04 h is 0.0129 h*ng/mL. ### Claim 14 A high dose naloxone composition including naloxone at a dose greater than or equal to about 5 mg configured for administration, wherein the AUC0-0.08 h is between 0.05 h*ng/mL to 0.2 h*ng/mL and the administration is an injection. ### Claim 15 (depends on 14) The high dose naloxone composition of claim 14, including naloxone hydrochloride at a dose of 5 mg/0.5 mL. ### Claim 16 (depends on 15) The high dose naloxone composition of claim 15, wherein the composition is configured for a single administration. ### Claim 17 (depends on 16) The high dose naloxone composition of claim 16, wherein the administration is using an injection device. ### Claim 18 (depends on 14) The high dose naloxone composition of claim 14, wherein the AUC0-0.08 h is 0.0782 h*ng/mL.