# US 11,027,070 B2 · Medical device for fluid delivery having reduced dead space

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- Number: US 11,027,070 B2
- Document ID: US11027070B2
- Status: Granted
- Kind: B2
- Application number: 15/766,598
- Filed: 2016-10-10
- Published: 2018-10-18
- Granted: 2021-06-08
- Earliest claimed: 2015-09-22
- Assignees: West Pharma. Services IL, Ltd.
- Applicants: West Pharma. Services IL, Ltd.
- Inventors: Oz Cabiri
- Web page: https://patentgrep.com/patent/US11027070B2

## CPC

- A61M 5/28: Syringe ampoules or carpules, i.e. ampoules or carpules provided with a needle
- A61M 5/3134: {characterised by constructional features of the distal end, i.e. end closest to the tip of the needle cannula}
- A61M 5/3202: {Devices for protection of the needle before use, e.g. caps (A61M5/50 takes precedence; protectors for sharps A61B50/3001)}
- A61M 5/3204: {Needle cap removers, i.e. devices to dislodge protection cover from needle or needle hub, e.g. deshielding devices}
- A61M 5/34: Constructions for connecting the needle {, e.g. to syringe nozzle or needle hub (connecting catheter tubes to hubs A61M25/0014)}
- B29C 33/12: with incorporated means for positioning inserts, e.g. labels {(positioning reinforcements B29C70/541)}
- B65D 1/36: with moulded compartments or partitions
- B65D 5/503: {Tray-like elements formed in one piece (formed by folding a blank B65D5/5038)}
- B65D 21/0233: {Nestable containers}
- B65D 25/108: {Devices, e.g. plates, presenting apertures through which the articles project}
- A61M 5/14248: {of the skin patch type}
- A61M 5/1456: {with a replaceable reservoir comprising a piston rod to be moved into the reservoir, e.g. the piston rod is part of the removable reservoir}
- A61M 2005/1581: {Right-angle needle-type devices}
- A61M 2005/312: {comprising sealing means, e.g. severable caps, to be removed prior to injection by, e.g. tearing or twisting}
- A61M 2005/341: {angularly adjustable or angled away from the axis of the injector}
- A61M 2205/3306: Optical measuring means
- A61M 2207/00: Methods of manufacture, assembly or production
- A61M 2209/06: Packaging for specific medical equipment
- B29L 2031/7544: {Injection needles, syringes}
- A61M: DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY (introducing media into or onto the bodies of animals A61D7/00; means for inserting tampons A61F13/26; devices for administering food or medicines orally A61J; containers for collecting, storing or administering blood or medical fluids A61J1/05); DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY (surgery A61B; chemical aspects of surgical articles A61L); DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR {(Electrotherapy, e.g. producing anaesthesia by the use of alternating or intermittent currents A61N1/36021)}
- B29C: SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING (making preforms B29B11/00; making laminated products by combining previously unconnected layers which become one product whose layers will remain together B32B37/00 - B32B41/00)
- B65D: CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
- B29L: INDEXING SCHEME ASSOCIATED WITH SUBCLASS B29C, RELATING TO PARTICULAR ARTICLES

## Abstract

Disclosed herein is a pharmaceutical syringe having a cylindrical bore with a proximal opening, the syringe comprising a distal wall of the bore defining an outlet biased from the central axis of the syringe, and toward a first area of the distal wall and biased from the central axis away from a second area distinct from the first area; the syringe comprising a plunger seal having a distal surface; wherein when the plunger seal is fitted into the bore with the distal surface facing an inner surface of the distal wall of the bore, the second area of the inner surface is axially closer to the distal surface of the plunger seal than the first area, in a direction parallel to the central axis of the cylindrical bore, such that fluid is expelled from the second area and towards the outlet.

## Claims

### Claim 1

A pharmaceutical syringe comprising:
a cylindrical bore having a proximal opening, a distal wall having an inner surface, an interior surface extending from said proximal opening to said distal wall, and a central axis, said inner surface having a first area and a second area distinct from said first area, said distal wall of said cylindrical bore defining an outlet, said outlet being spaced from said central axis toward said first area and away from said second area;
a hub extending from said distal wall, said hub defining a hub outlet and a fluid path extending from said outlet of said cylindrical bore to said hub outlet; and
a plunger seal positioned within and coaxial to said cylindrical bore, said plunger seal having a side surface configured to slidingly engage the interior surface of the cylindrical bore, a distal surface defining a center, the distal surface extending either perpendicular to said central axis or proximally as it extends radially from said center to said side surface;
wherein when said plunger seal is fitted within said cylindrical bore with said distal surface facing said inner surface of said distal wall of said cylindrical bore, said second area of said inner surface is axially closer to said distal surface of said plunger seal than said first area, in a direction parallel to said central axis of said cylindrical bore, allowing said second area to contact said distal surface of said plunger seal before said distal surface contacts said first area.

### Claim 2 (depends on 1)

The pharmaceutical syringe of claim 1, wherein a mean direction of said inner surface is tilted with respect to said central axis.

### Claim 3 (depends on 2)

The pharmaceutical syringe of claim 2, wherein said mean direction of said inner surface is tilted at an angle ranging from about 1 to about 5 degrees with respect to said central axis.

### Claim 4 (depends on 1)

The pharmaceutical syringe of claim 1, wherein said distal surface of said plunger seal comprises a convex shape with respect to the plunger seal.

### Claim 5 (depends on 4)

The pharmaceutical syringe of claim 4, wherein said inner surface comprises a concave shape with respect to the plunger seal.

### Claim 6 (depends on 5)

The pharmaceutical syringe of claim 5, wherein said inner surface comprises a conical shape, and wherein an opening angle of said inner surface is less sharp than an opening angle of said convex shape of said distal face of said plunger seal.

### Claim 7 (depends on 1)

The pharmaceutical syringe of claim 1, wherein said inner surface is not radially symmetrical.

### Claim 8 (depends on 1)

The pharmaceutical syringe of claim 1, wherein a mean direction of said first area of said inner surface is not parallel to a mean direction of said distal surface of said plunger seal, when said plunger seal being coaxial to said bore.

### Claim 9 (depends on 1)

The pharmaceutical syringe of claim 1, wherein a mean direction of said second area of said inner wall is parallel to a mean direction of said distal surface of said plunger seal, when said plunger seal being coaxial to said bore.

### Claim 10 (depends on 1)

The pharmaceutical syringe of claim 1, wherein a distance between a mean outer edge of the distal surface of the plunger seal and a mean outer edge of said second area being smaller than a distance between said mean outer edge of the distal surface of the plunger seal and a mean outer edge of said first area.

### Claim 11 (depends on 1)

The pharmaceutical syringe of claim 1, wherein a transition between a surface of said first area of said inner surface and a surface of said second area of said inner surface is continuous.

### Claim 12 (depends on 1)

The pharmaceutical syringe of claim 1, wherein said first area of said inner wall comprising said fluid outlet is located in proximity to an edge of said bore and said second area is located in proximity to the opposite edge of said bore.

### Claim 13 (depends on 1)

The pharmaceutical syringe of claim 1, further comprising a bent fluid path originating from said fluid outlet.

### Claim 14

A method for reducing fluid dead space in a pharmaceutical syringe comprising a cylindrical bore with a proximal opening and a distal end including a fluid outlet spaced from a central axis of the cylindrical bore and an interior surface extending from said proximal opening to said distal end, and a hub extending from said distal end of said cylindrical bore, said hub defining a hub outlet and a fluid path extending from said outlet of said cylindrical bore to said hub outlet, and said cylindrical bore fitting a plunger seal having a distal surface, the plunger seal having a side surface configured to slidingly engage the interior surface of the cylindrical bore, the method comprising:
driving said plunger seal towards said distal end of said cylindrical bore, the distal surface of said plunger seal extending either perpendicular to said central axis or proximally as it extends radially from said central axis to said side surface;
contacting a portion of said distal surface of said plunger seal with a portion of an inner surface of a wall of said distal end of said cylindrical bore at a contact area distinct from an area comprising the fluid outlet; and
expanding a range of contact from said contact area towards the location of the fluid outlet while expelling fluid in a mean direction which is tilted with respect to a mean direction of said distal surface of said plunger seal,
wherein said contacting at said contact area comprises contacting said distal surface of said plunger seal before contacting said area comprising the fluid outlet.

### Claim 15 (depends on 14)

The method of claim 14, wherein said contacting comprises initially contacting at said contact area being a peripheral edge of said inner surface, said peripheral edge being distinct to said area comprising said fluid outlet.

### Claim 16 (depends on 14)

The method of claim 14, wherein said expanding comprises expanding said range of contact from said peripheral edge, through a center portion of said inner wall and onto said area comprising said fluid outlet.

### Claim 17 (depends on 14)

The method of claim 14, wherein said expanding said range of contact is conducted by elastically deforming said plunger seal.

### Claim 18 (depends on 14)

The method of claim 14, wherein said expanding said range of contact results in driving fluid away from said contact location towards said location of said fluid outlet.

### Claim 19 (depends on 14)

The method of claim 14, further comprising ending said driving of said plunger seal at a force ranging between about 5 N and about 25 N.

### Claim 20 (depends on 19)

The method of claim 19, wherein following said ending, a volume of a fluid dead space between said plunger seal and said inner wall ranges between about 0.01 ml and about 0.5 ml.