# US 11,027,066 B2 · Three-chambered autoinjector > Agents: this data is available as JSON from the patentgrep API and MCP server — see https://patentgrep.com/llms.txt - Number: US 11,027,066 B2 - Document ID: US11027066B2 - Status: Granted - Kind: B2 - Application number: 15/784,448 - Filed: 2017-10-16 - Published: 2018-02-08 - Granted: 2021-06-08 - Earliest claimed: 2010-12-30 - Assignees: Meridian Medical Technologies, Inc. - Applicants: Meridian Medical Technologies, Inc. - Inventors: John Glyndwr Wilmot; Robert Leavitt Hill - Web page: https://patentgrep.com/patent/US11027066B2 ## CPC - A61M 5/19: having more than one chamber - A61M 5/2066: {comprising means for injection of two or more media, e.g. by mixing} - A61M 5/2033: {Spring-loaded one-shot injectors with or without automatic needle insertion (multishot dosing syringes A61M5/31525, needle insertion only A61M5/3287)} - A61M 5/206: {with automatic needle insertion} - A61M: DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY (introducing media into or onto the bodies of animals A61D7/00; means for inserting tampons A61F13/26; devices for administering food or medicines orally A61J; containers for collecting, storing or administering blood or medical fluids A61J1/05); DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY (surgery A61B; chemical aspects of surgical articles A61L); DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR {(Electrotherapy, e.g. producing anaesthesia by the use of alternating or intermittent currents A61N1/36021)} ## Abstract The present invention relates to a three-chambered autoinjector as well as to the methods of administering medicaments to a human using the three-chambered autoinjector. In certain embodiments, the autoinjector includes a first medicament in liquid form, a second medicament preferably in solid form, and a liquid composition for diluting the second medicament, and utilizes a three-chambered design so as to administer the first medicament and a solution comprising the second medicament and the liquid composition at different injection depths into the body of a human. In an alternative embodiment an autoinjector is provided that delivers medicaments at the same injection depth. ## Claims ### Claim 1 An autoinjector comprising: a) a housing having a forward end and a rear end; b) a rear plunger moveably situated within the housing; c) a separation assembly moveably situated within the housing, the separation assembly forwardly situated with respect to the rear plunger; d) a separation plunger moveably situated within the housing, the separation plunger forwardly situated with respect to the separation assembly; e) a first medicament situated forwardly with respect to the separation plunger, the first medicament in the form of a liquid; f) a second medicament situated between the separation plunger and the separation assembly; g) a liquid composition situated between the separation assembly and the rear plunger; h) a needle having a needle length, a forward end and a rear end, the needle being moveable from a needle storage position in which the needle is situated within the housing to a needle fully extended position in which the needle reaches a maximal extension out of the forward end of the housing; and i) an activatable power assembly for moving the rear plunger forwardly within the housing. ### Claim 2 (depends on 1) The autoinjector of claim 1, wherein, after activation of the power assembly, the power assembly causes the separation plunger, the separation assembly, and the rear plunger to move forwardly within the housing and the needle to move from the needle storage position to the needle fully extended position. ### Claim 3 (depends on 1) The autoinjector of claim 1, wherein the separation assembly comprises a separation assembly bypass, the separation assembly bypass having a closed position in which the separation assembly bypass prohibits the liquid composition from flowing through the separation assembly and mixing with the second medicament and an open position for allowing the liquid composition to flow through the separation assembly and mix with the second medicament. ### Claim 4 (depends on 1) The autoinjector of claim 1, wherein the housing comprises a punctureable sheath situated over the forward end of the needle so that the needle can puncture through the sheath and extend from the housing after activation of the power assembly. ### Claim 5 (depends on 1) The autoinjector of claim 1, wherein the needle comprises an interior, an exterior, a first opening for allowing the first medicament and a solution comprising the liquid composition and the second medicament to enter into the interior of the needle from the housing, a second opening for allowing the first medicament and the solution to be ejected from the needle, and a passage for allowing the first medicament and the solution to flow through the interior of the needle by entering through the first opening and exiting from the second opening. ### Claim 6 (depends on 1) The autoinjector of claim 1, wherein the autoinjector further comprises a bypass within the housing, the bypass forwardly situated with respect to the separation plunger prior to the activation of the power assembly, the bypass forming a bypass area within the housing for receiving the separation plunger so that when the separation plunger is received in the bypass area, a solution comprising the liquid composition and the second medicament can flow around the separation plunger and into an opening in the needle. ### Claim 7 (depends on 1) The autoinjector of claim 1, wherein the separation plunger rearwardly confines the first medicament. ### Claim 8 (depends on 1) The autoinjector of claim 1, wherein the second medicament is in the form of a solid. ### Claim 9 (depends on 8) The autoinjector of claim 8, wherein the second medicament is a lyophilized medicament. ### Claim 10 (depends on 1) The autoinjector of claim 1, wherein the liquid composition is an aqueous solution. ### Claim 11 An autoinjector having three chambers, the autoinjector comprising: a) a housing having a forward end and a rear end; b) a rear plunger moveably situated within the housing; c) a separation assembly moveably situated within the housing, the separation assembly forwardly situated with respect to the rear plunger; d) a separation plunger moveably situated within the housing, the separation plunger forwardly situated with respect to the separation assembly; e) a first chamber for a liquid composition, the first chamber having a variable volume, the first chamber forwardly confined by the separation assembly and rearwardly confined by the rear plunger; f) a second chamber for a second medicament, the second chamber having a variable volume, the second chamber forwardly confined by the separation plunger and rearwardly confined by the separation assembly; g) a third chamber for a first medicament, the third chamber having a variable volume, the third chamber rearwardly confined by the separation plunger; h) a needle having a needle length, a forward end and a rear end, the needle being moveable from a needle storage position in which the needle is situated within the housing to a needle fully extended position in which the needle reaches a maximal extension out of the forward end of the housing; and i) an activatable power assembly for moving the rear plunger forwardly within the housing. ### Claim 12 (depends on 11) The autoinjector according to claim 11, wherein, after activation of the power assembly, the power assembly causes i) the rear plunger to move forwardly within the housing so as to decrease the volume of the first chamber; ii) the separation assembly to move forwardly within the housing so as to decrease the volume of the second chamber; iii) the separation plunger to move forwardly within the housing so as to decrease the volume of the third chamber; and iv) the needle to move from the needle storage position to the needle fully extended position. ### Claim 13 (depends on 11) The autoinjector claim 11, wherein the separation assembly comprises a separation assembly bypass for allowing the liquid composition to flow from the first chamber through the separation assembly and into the second chamber. ### Claim 14 (depends on 11) The autoinjector of claim 11, including a first medicament contained in the third chamber, the first medicament in the form of a liquid. ### Claim 15 (depends on 11) The autoinjector of claim 11, including a second medicament contained in the second chamber, the second medicament in the form of a solid. ### Claim 16 (depends on 11) The autoinjector of claim 11, including a liquid composition contained in the first chamber.