# US 11,027,041 B2 · Stable and robust blended hemostatic composition

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- Number: US 11,027,041 B2
- Document ID: US11027041B2
- Status: Granted
- Kind: B2
- Application number: 16/458,134
- Filed: 2019-06-30
- Published: 2020-12-31
- Granted: 2021-06-08
- Earliest claimed: 2019-06-30
- Applicants: James Drake
- Inventors: James Drake
- Web page: https://patentgrep.com/patent/US11027041B2

## CPC

- A61L 24/0094: {containing macromolecular fillers}
- A61L 24/0036: {Porous materials, e.g. foams or sponges}
- A61L 2400/04: Materials for stopping bleeding
- A61L: METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES (preservation of bodies or disinfecting characterised by the agents employed A01N; preserving, e.g. sterilising, food or foodstuffs A23; preparations for medical, dental or toiletry purposes A61K)

## Abstract

A hemostatic composition of matter includes a coherent blend of collagen fibrils combined with starch particles as a fluffy mass with hemostatic properties better than collagen fibrils alone or starch particles alone, the composition exhibiting a level of coherence wherein the composition can be lifted, without crushing fibrils, without loss of more than 5% of 10% of a total weight of starch particles from the composition. Sheets with less than 10% by weight of additional binder are also disclosed.

## Claims

### Claim 1

A method of forming a coherent and stable fluffy powder composition of matter comprising a dry powder blend of collagen fibrils adhered to starch particles as a fluffy mass with at least 40% by volume of air with hemostatic properties by physically admixing the collagen fibrils and the starch particles together in a weight ratio of from 2% to 95% of the collagen fibrils and from 98% to 5% of the starch particles based on a total weight of the fluffy power composition, conditioning the blend of collagen fibrils and starch particles to contain 8% to 15% volatiles selected from the group consisting of water and organic liquid for 8 to 24 hours, drying the conditioned blend, and then deaggregating the dried conditioned blend, the fluffy powder composition exhibiting a level of coherence wherein the fluffy powder composition can be lifted, without crushing the collagen fibrils and without loss of more than 10% by a total weight of the starch particles.

### Claim 2 (depends on 1)

The method of claim 1 wherein the collagen fibrils have an average length of less than 1000 μm.

### Claim 3 (depends on 1)

The method of claim 1 wherein the starch particles have an average diameter of less than 1000 μm.

### Claim 4 (depends on 2)

The method of claim 2 wherein the starch particles have an average diameter of less than 1000 μm.

### Claim 5 (depends on 1)

The method of claim 1 wherein the coherent and stable fluffy powder composition consists essentially of collagen fibrils and starch particles.

### Claim 6 (depends on 1)

The method of claim 1 wherein the coherent and stable fluffy powder composition consists essentially of collagen fibrils and starch particles and less than 10% by weight of an adhesive based on the total weight of the composition.

### Claim 7 (depends on 1)

The method of claim 1 wherein the coherent and stable fluffy powder composition consists essentially of collagen fibrils and starch particles and less than 3% by weight of an adhesive based on a total weight of the composition.

### Claim 8 (depends on 1)

The method of claim 1 wherein the stable fluffy powder composition has at least 90% by volume of air.

### Claim 9 (depends on 1)

The method of claim 1 wherein the stable fluffy powder composition contains 0% binder in addition to the starch and chitosan.