# US 11,027,019 B2 · Methods of making antimicrobial biopolymer from sodium alginate and algae extract using aminoglycosides, and methods of using the same

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- Number: US 11,027,019 B2
- Document ID: US11027019B2
- Status: Granted
- Kind: B2
- Application number: 16/670,558
- Filed: 2019-10-31
- Published: 2020-04-30
- Granted: 2021-06-08
- Earliest claimed: 2018-10-31
- Applicants: Colorado School of Mines
- Inventors: Lokender Kumar; John Brice; Linda Toberer; Judith Klein-Seetharaman; Daniel Knauss; Susanta Kumar Sarkar
- Web page: https://patentgrep.com/patent/US11027019B2

## CPC

- A61K 47/36: Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
- A61K 9/0014: {Skin, i.e. galenical aspects of topical compositions (non-active ingredients are additionally classified in A61K47/00; A61K9/0009, A61K9/0021, A61K9/7015, A61K9/7023 take precedence; cosmetic preparations A61K8/00, A61Q; preparations for wound dressings or bandages A61L26/00)}
- A61K 9/7007: {Drug-containing films, membranes or sheets (A61K9/0041, A61K9/0043, A61K9/006, A61K9/0063 take precedence)}
- A61K 31/702: Oligosaccharides, i.e. having three to five saccharide radicals attached to each other by glycosidic linkages
- A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D)

## Abstract

Methods of forming antimicrobial biopolymers from sodium alginate and algae extract using aminoglycosides are presented. Also presented are improved biopolymers, methods of making the biopolymers, and methods of using the biopolymers, wherein the biopolymer includes a sodium alginate and an aminoglycoside.

## Claims

### Claim 1

A polymer, comprising:
a sodium alginate; and
an aminoglycoside, wherein the polymer is used to heal a wound.

### Claim 2 (depends on 1)

The polymer of claim 1, wherein the sodium alginate comprises undaria pinnatifida.

### Claim 3 (depends on 1)

The polymer of claim 1, wherein the aminoglycoside comprises kanamycin disulfate.

### Claim 4 (depends on 2)

The polymer of claim 2, wherein the aminoglycoside comprises kanamycin disulfate.

### Claim 5 (depends on 1)

The polymer of claim 1, wherein the aminoglycoside comprises neomycin sulfate.

### Claim 6 (depends on 1)

The polymer of claim 1, wherein the polymer is applied to a bandage on wound site.

### Claim 7 (depends on 1)

The polymer of claim 1, wherein the polymer is applied to a dressing.

### Claim 8 (depends on 1)

The polymer of claim 1, wherein the polymer is applied to skin.

### Claim 9

A composition for treating a bacterial infection, comprising:
a polymer, comprising:
a sodium alginate; and
an aminoglycoside.

### Claim 10 (depends on 9)

The composition of claim 9, wherein the sodium alginate comprises undaria pinnatifida.

### Claim 11 (depends on 9)

The composition of claim 9, wherein the aminoglycoside comprises kanamycin disulfate.