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US 11,027,011 B2Granted
Vaccines with biomolecular adjuvants
AssigneeThe Trustees of the University of Pennsylvania
InventorsDavid B. Weiner, Karuppiah Muthumani
Life of this patent
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Abstract
Disclosed herein is a vaccine comprising an antigen and one or more bimolecular adjuvant. Also disclosed herein are methods for increasing an immune response in a subject. The methods may comprise administering the vaccine to the subject in need thereof.
Claims18
A vaccine comprising a nucleotide sequence encoding an antigen selected from the group consisting of:
- human papilloma virus (HPV) antigen, an HIV antigen, an influenza antigen, and a Plasmodium falciparum antigen, and a nucleotide sequence encoding one or more adjuvants selected from the group consisting of:
- T-box transcription factor TBX21 (T-bet), Eomesodermin (Eomes), FMS-like tyrosine kinase 3 ligand (FLT3L), TNF-related weak inducer of apoptosis (TWEAK), Glucocorticoid-induced tumor necrosis factor related protein ligand (GITRL) and Stimulator of interferon genes (STING), wherein said nucleotide sequence encoding T-bet comprises a sequence that is 95% identical or greater to SEQ ID NO:
- 3, said nucleotide sequence encoding Eomes comprises a sequence that is 96% identical or greater to SEQ ID NO:5, said nucleotide sequence encoding FLTL3 comprises a sequence that is 95% identical or greater to SEQ ID NO:7, said nucleotide sequence encoding TWEAK comprises a sequence that is 95% identical or greater to SEQ ID NO:9, said nucleotide sequence encoding GITRL comprises a sequence that is 95% identical or greater to SEQ ID NO:11, and said nucleotide sequence encoding STING comprises a sequence that is 95% identical or greater to SEQ ID NO:13.
A nucleic acid molecule comprising one or more nucleotide sequences selected from the group consisting of:
- SEQ ID NO:7, SEQ ID NO:9, SEQ ID NO:11, SEQ ID NO:13, a nucleotide sequence that is 95% identical or greater to SEQ ID NO:7, a nucleotide sequence that is 95% identical or greater to SEQ ID NO:9, a nucleotide sequence that is 95% identical or greater to SEQ ID NO:11, a nucleotide sequence that is 95% identical or greater to SEQ ID NO:13 and a combination thereof.
Dependencies are inferred from the claim text.