# US 11,026,984 B2 · Use of isothiocyanate derivatives as modulators of peripheral and neuropathic pain

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- Number: US 11,026,984 B2
- Document ID: US11026984B2
- Status: Granted
- Kind: B2
- Application number: 15/564,748
- Filed: 2016-03-30
- Published: 2018-04-19
- Granted: 2021-06-08
- Earliest claimed: 2015-04-10
- Assignees: Indena S.p.A.
- Applicants: Indena S.P.A.
- Inventors: Paolo Morazzoni; Renato Iori
- Web page: https://patentgrep.com/patent/US11026984B2

## CPC

- A61K 36/185: Magnoliopsida (dicotyledons)
- A61K 31/26: Cyanate or isocyanate esters; Thiocyanate or isothiocyanate esters
- A61K 31/7024: Esters of saccharides
- A61K 31/7034: attached to a carbocyclic compound, e.g. phloridzin
- A61P 25/00: Drugs for disorders of the nervous system
- A61P 25/02: for peripheral neuropathies
- A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D)
- A61P: SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS

## Abstract

The present invention relates to the use of glucomoringin (GMG) and of the corresponding isothiocyanate derivative glucomoringin des-thioglucoside (GMG-ITC) as modulators of peripheral pain with specific reference to that linked with diabetic peripheral neuropathy and chemotherapy-induced neuropathy.

## Claims

### Claim 1

Method of treating oxaliplatin-induced neuropathy in a subject in need thereof, said method comprising
administering glucomoringin, or glucomoringin des-thioglucoside, or an extract of Moringa oleifera seeds containing glucomoringin and/or glucomoringin des-thioglucoside to said subject; and
treating said subject of said oxaliplatin-induced neuropathy.

### Claim 2 (depends on 1)

A method according to claim 1, comprising administering glucomoringin.

### Claim 3 (depends on 1)

A method according to claim 1, comprising administering glucomoringin des-thioglucoside.