# US 11,026,960 B2 · Esters of 2-deoxy-monosaccharides with anti proliferative activity

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- Number: US 11,026,960 B2
- Document ID: US11026960B2
- Status: Granted
- Kind: B2
- Application number: 16/229,338
- Filed: 2018-12-21
- Published: 2019-07-25
- Granted: 2021-06-08
- Earliest claimed: 2013-04-05
- Assignees: Board of Regents, The University of Texas System
- Applicants: Board of Regents, The University of Texas System; Kim Conrad
- Inventors: Waldemar Priebe; Marcin Cybulski; Izabela Fokt; Stanislaw Skora; Charles Conrad; Timothy Madden
- Web page: https://patentgrep.com/patent/US11026960B2

## CPC

- A61K 31/7024: Esters of saccharides
- A61P 35/00: Antineoplastic agents
- A61P 35/02: specific for leukemia
- A61P 35/04: specific for metastasis
- A61P 43/00: Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D)
- A61P: SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS

## Abstract

Compounds and methods of using the same to inhibit glycolysis and treat cancer and other diseases are disclosed.

## Claims

### Claim 1

A method of treating brain or pancreatic cancer in a patient in need thereof comprising administering a therapeutically effective amount of one or more compounds of the Formula I:
or a salt thereof, wherein:
each R1, R2, R3 and R4 are independently H, or C(O)R5;
at least two of R1, R2, R3 and R4 is C(O)R5; and
each R5 is independently selected from C3-C7 straight- or branched-chain alkyl, C4-C10 alkylcycloalkyl, and C3-C7 cycloalkyl.

### Claim 2 (depends on 1)

The method of claim 1, wherein R2 and R3 are C(O)R5.

### Claim 3 (depends on 1)

The method of claim 1, wherein the compound is chosen from:

### Claim 4

A method of treating brain or pancreatic cancer in a patient in need thereof comprising administering a therapeutically effective amount of the compound

### Claim 5

A method of treating brain or pancreatic cancer in a patient in need thereof comprising administering a therapeutically effective amount of the compound