# US 11,026,955 B2 · Synthetic bile acid compositions and methods

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- Number: US 11,026,955 B2
- Document ID: US11026955B2
- Status: Granted
- Kind: B2
- Application number: 16/575,323
- Filed: 2019-09-18
- Published: 2020-03-12
- Granted: 2021-06-08
- Earliest claimed: 2007-06-19
- Assignees: Allergan Sales, Inc.
- Applicants: Allergan Sales, LLC
- Inventors: Robert M. Moriarty; Nathaniel E. David; Nadir Ahmeduddin Mahmood
- Web page: https://patentgrep.com/patent/US11026955B2

## CPC

- A61K 31/575: substituted in position 17 beta by a chain of three or more carbon atoms, e.g. cholane, cholestane, ergosterol, sitosterol
- A61K 38/08: Peptides having 5 to 11 amino acids {(A61K38/043 - A61K38/046 take precedence)}
- A61K 45/06: Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
- A61K 47/24: containing atoms other than carbon, hydrogen, oxygen, halogen, nitrogen or sulfur, e.g. cyclomethicone or phospholipids
- A61P 3/00: Drugs for disorders of the metabolism (of the blood or the extracellular fluid A61P7/00)
- C07J 9/00: Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane
- A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D)
- A61P: SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- C07J: STEROIDS (seco-steroids C07C)

## Abstract

Bile acids and related compositions and methods of synthesis and use. More specifically, deoxycholic acid and related compositions, said compositions being free of all moieties of animal origin and free of pyrogenic moieties.

## Claims

### Claim 1

A method for emulsifying fat in a mammal in need thereof, the method comprising administering locally to said mammal a composition comprising: a therapeutically effective amount of DCA
or a pharmaceutically acceptable salt thereof, wherein the DCA comprises a synthetic side chain of formula:
and at least one pharmaceutically acceptable excipient and/or carrier.

### Claim 2 (depends on 1)

The method of claim 1, wherein the DCA or the pharmaceutically acceptable salt thereof is present in the composition in an amount of about 0.1% w/v to about 2% w/v.

### Claim 3 (depends on 1)

The method of claim 1, wherein the composition further comprises phosphatidylcholine.

### Claim 4 (depends on 3)

The method of claim 3, wherein the phosphatidylcholine is present in the composition in an amount of up to 5% w/v.

### Claim 5 (depends on 1)

The method of claim 1, wherein the composition does not contain phosphatidylcholine.

### Claim 6 (depends on 1)

The method of claim 1, wherein the DCA, or a pharmaceutically acceptable salt thereof, is sodium deoxycholate.

### Claim 7 (depends on 1)

The method of claim 1, wherein the administering involves delivering the composition via a subcutaneous or transdermal injection.

### Claim 8 (depends on 1)

The method of claim 1, wherein the composition is administered to a region under eye, under chin, under arm, buttock, calf, back, thigh, or stomach of said mammal.