# US 11,026,942 B2 · Agent for preventing and/or treating Alzheimer's disease

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- Number: US 11,026,942 B2
- Document ID: US11026942B2
- Status: Granted
- Kind: B2
- Application number: 16/066,946
- Filed: 2016-12-29
- Published: 2019-01-10
- Granted: 2021-06-08
- Earliest claimed: 2015-12-29
- Assignees: Kyoto University
- Applicants: Kyoto University
- Inventors: Haruhisa Inoue; Takayuki Kondo
- Web page: https://patentgrep.com/patent/US11026942B2

## CPC

- A61K 31/4985: Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
- A61K 31/095: Sulfur, selenium, or tellurium compounds, e.g. thiols
- A61K 31/10: Sulfides; Sulfoxides; Sulfones
- A61K 31/352: condensed with carbocyclic rings, e.g. methantheline {(cannabinoids A61K31/658)}
- A61K 31/353: 3,4-Dihydrobenzopyrans, e.g. chroman, catechin
- A61K 31/357: having two or more oxygen atoms in the same ring, e.g. crown ethers, guanadrel
- A61K 31/404: Indoles, e.g. pindolol
- A61K 31/405: Indole-alkanecarboxylic acids; Derivatives thereof, e.g. tryptophan, indomethacin
- A61K 31/4709: Non-condensed quinolines and containing further heterocyclic rings
- A61K 31/48: Ergoline derivatives, e.g. lysergic acid, ergotamine
- A61K 31/7048: having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin {, digitoxin or digoxin}
- A61K 45/06: Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
- A61P 25/28: for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D)
- A61P: SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS

## Abstract

The present invention provides a prophylactic or therapeutic agent for Alzheimer's disease (AD) containing a combination of two or more compounds selected from the group consisting of compounds shown by compound Nos. 1 to 130. Since these compounds are existing drugs that have already been confirmed actually for safety and pharmacokinetics in human, they can be a means for a pre-emptive treatment of people at risk of AD and in a stage before developing mild cognitive impairment (MCI).

## Claims

### Claim 1

A method for reducing Aβ42/Aβ40 ratio in the brain of a subject, comprising administering to the subject an effective amount of each of bromocriptine and topiramate,
wherein
the effective amount of each of bromocriptine and topiramate is not more than a maximum nontoxic dose of each of bromocriptine and topiramate, and
the Aβ42/Aβ40 ratio in the brain of the subject is reduced relative to the Aβ42/Aβ40 ratio in the brain of the subject in the absence of administering bromocriptine and topiramate to the subject.

### Claim 2 (depends on 1)

The method according to claim 1, further comprising administering to the subject an effective amount of cromolyn, wherein the effective amount of each of bromocriptine, topiramate, and cromolyn is a clinically-used dose of each compound.

### Claim 3 (depends on 2)

The method of claim 2, where the method is for treating Alzheimer's disease in the subject.

### Claim 4 (depends on 1)

The method of claim 1, wherein the method is for treating Alzheimer's disease in the subject.