Heteroaryl inhibitors of PAD4

A compound of formula I or formula II:

• or a pharmaceutically acceptable salt thereof, wherein:
• R1 is S(CH3),
• R2 is hydrogen or optionally substituted C1-6-aliphatic;
• L is
• R3 is
• R4 is R or C(O)OR;
• each R is independently hydrogen or Ci-6 aliphatic optionally substituted with 1-3 fluorine atoms;
• R5 is hydrogen or CN;
• Rx and Ry are taken together with their intervening atoms to form a optionally substituted 5-6 membered saturated, partially unsaturated, or aromatic fused ring having 1-2 heteroatoms independently selected from nitrogen, oxygen, or sulfur.