# US 11,026,932 B2 · Medicinal composition for preventing or treating inflammatory respiratory disease

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- Number: US 11,026,932 B2
- Document ID: US11026932B2
- Status: Granted
- Kind: B2
- Application number: 15/772,901
- Filed: 2016-09-09
- Published: 2020-06-11
- Granted: 2021-06-08
- Earliest claimed: 2015-09-10
- Assignees: National University Corporation Okayama University
- Applicants: National University Corporation Okayama University
- Inventors: Arihiko Kanehiro; Utako Fujii; Daisuke Morichika; Naohiro Oda; Nobuaki Miyahara; Akihiko Taniguchi; Hiroki Kakuta
- Web page: https://patentgrep.com/patent/US11026932B2

## CPC

- A61K 31/44: Non condensed pyridines; Hydrogenated derivatives thereof
- A61K 31/4184: condensed with carbocyclic rings, e.g. benzimidazoles
- A61K 31/4188: condensed with other heterocyclic ring systems, e.g. biotin, sorbinil
- A61K 31/4192: 1,2,3-Triazoles
- A61K 31/4745: condensed with ring systems having nitrogen as a ring hetero atom, e.g. phenantrolines (yohimbine derivatives, vinblastine A61K31/475; ergoline derivatives A61K31/48)
- A61P 11/00: Drugs for disorders of the respiratory system
- A61P 11/06: Antiasthmatics
- A61P 11/08: Bronchodilators
- A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D)
- A61P: SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS

## Abstract

A method for treating an inflammatory respiratory disease, comprising administering an effective amount of an RXR agonist represented by formula (1) or (2) as an active ingredient. wherein D, R1, R2, X, Y, Z, R3, R4, X1, Y1, X2, Y2 and Z1 are defined.

## Claims

### Claim 1

A method for treating an inflammatory respiratory disease, comprising administering an effective amount of RXR agonist as an active ingredient, wherein the inflammatory respiratory disease is emphysema or bronchial asthma wherein the RXR agonist is a compound represented by Formula (1)
wherein D is selected cMe2, N-ethyl N-isopropyl;
R1 is selected from a methyl group, a hydroxy group, a methoxy group or an ethoxy group,
R2 is selected from H, a methyl group or an ethyl group;
X is selected from N, CH or C—CF3,
Y is selected from N or CH;
Z is CH.

### Claim 2 (depends on 1)

The method as claimed in claim 1, wherein the RXR agonist is a compound represented by Formula (3):
wherein X is selected from N or C—CF3.

### Claim 3 (depends on 1)

The method as claimed in claim 1, wherein the inflammatory respiratory disease is emphysema.

### Claim 4 (depends on 1)

The method as claimed in claim 1, wherein the inflammatory respiratory disease is bronchial asthma.

### Claim 5 (depends on 1)

The method as claimed in claim 1, wherein X is N, and Y is N.

### Claim 6 (depends on 5)

The method as claimed in claim 5, wherein the inflammatory respiratory disease is emphysema.

### Claim 7 (depends on 5)

The method as claimed in claim 5, wherein the inflammatory respiratory disease is bronchial asthma.

### Claim 8 (depends on 1)

The method as claimed in claim 1, wherein the RXR agonist is a compound represented by Formula (1):
wherein D is selected from CMe2, N-methyl, N-ethyl or N-isopropyl;
R1 is selected from a methyl group, a hydroxy group, a methoxy group or an ethoxy group;
R2 is selected from H, a methyl group or an ethyl group;
X is N;
Y is selected from N or CH;
Z is CH.

### Claim 9 (depends on 1)

The method as claimed in claim 1, wherein the RXR agonist is a compound represented by Formula (1a):
wherein D is selected from CMe2, N-methyl, N-ethyl or N-isopropyl;
R1 is selected from a methyl group, a hydroxy group, a methoxy group or an ethoxy group;
R2 is selected from H, a methyl group or an ethyl group;
X is selected from CH or C—CF3;
Y is selected from N or CH;
Z is CH.

### Claim 10 (depends on 1)

The method as claimed in claim 1, wherein the RXR agonist is a compound represented by Formula (1b):
wherein D is selected from CMe2, N-methyl, N-ethyl or N-isopropyl;
R1 is selected from a methyl group, a hydroxy group, a methoxy group or an ethoxy group;
R2 is selected from H, a methyl group or an ethyl group;
X is selected from N, CH or C—CF3;
Y is N;
Z is CH.

### Claim 11 (depends on 1)

The method as claimed in claim 1, wherein the RXR agonist is a compound represented by Formula (1c):
wherein D is selected from CMe2, N-methyl, N-ethyl or N-isopropyl;
R1 is selected from a methyl group, a hydroxy group, a methoxy group or an ethoxy group;
R2 is selected from H, a methyl group or an ethyl group;
X is selected from N, CH or C—CF3;
Y is CH;
Z is CH.