# US 11,026,929 B2 · Administration of berberine metabolites

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- Number: US 11,026,929 B2
- Document ID: US11026929B2
- Status: Granted
- Kind: B2
- Application number: 16/403,992
- Filed: 2019-05-06
- Published: 2019-08-22
- Granted: 2021-06-08
- Earliest claimed: 2016-04-19
- Assignees: Keto Patent Group, Inc.
- Applicants: Keto Patent Group, Inc.
- Inventors: Ryan Lowery; Jacob Wilson; Terry LaCore
- Web page: https://patentgrep.com/patent/US11026929B2

## CPC

- A61K 31/4355: the heterocyclic ring system containing a five-membered ring having oxygen as a ring hetero atom
- A61K 9/1075: {Microemulsions or submicron emulsions; Preconcentrates or solids thereof; Micelles, e.g. made of phospholipids or block copolymers (A61K9/0026 takes precedence)}
- A61K 31/00: Medicinal preparations containing organic active ingredients
- A61K 31/19: Carboxylic acids, e.g. valproic acid (salicylic acid A61K31/60)
- A61K 31/4745: condensed with ring systems having nitrogen as a ring hetero atom, e.g. phenantrolines (yohimbine derivatives, vinblastine A61K31/475; ergoline derivatives A61K31/48)
- A61K 36/889: Arecaceae, Palmae or Palmaceae (Palm family), e.g. date or coconut palm or palmetto
- A61K 45/06: Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
- A61K 47/44: Oils, fats or waxes according to two or more groups of A61K47/02-A61K47/42; Natural or modified natural oils, fats or waxes, e.g. castor oil, polyethoxylated castor oil, montan wax, lignite, shellac, rosin, beeswax or lanolin (synthetic glycerides, e.g. medium-chain triglycerides, A61K47/14)
- A61K 47/6911: {the form being a liposome}
- A61P 3/08: for glucose homeostasis (pancreatic hormones A61P5/48)
- A61K 9/0053: {Mouth and digestive tract, i.e. intraoral and peroral administration}
- A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D)
- A61P: SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS

## Abstract

In various implementations, berberine metabolites, such as dihydroberberine and/or tetrahydroberberine, may be administered to manage blood glucose levels, increase ketone levels (e.g., blood concentration of ketones), and/or for therapeutic purposes in humans. The administration of a pharmaceutically effective amount of berberine metabolites, such as dihydroberberine, may reduce fasting blood glucose levels, improve glucose tolerance, and/or improve blood ketone response. In some implementations, berberine metabolites may be administered with one or more other compounds.

## Claims

### Claim 1

A method of managing glucose tolerance in an individual, the method comprising:
administering, to an individual a pharmaceutically effective amount of R-beta-hydroxybutyrate, wherein the pharmaceutically effective amount of R-beta-hydroxybutyrate comprises less than approximately 2 g of R-beta-hydroxybutyrate.

### Claim 2 (depends on 1)

The method of claim 1 wherein the R-beta-hydroxybutyrate comprises at least 90 percent R-beta-hydroxybutyrate and less than 10 percent L-beta-hydroxybutyrate.

### Claim 3 (depends on 1)

The method of claim 1 wherein the R-beta-hydroxybutyrate comprises at least one of a beta-hydroxybutyrate salt or beta-hydroxybutyrate polymer.

### Claim 4 (depends on 1)

The method of claim 1 wherein the administration of composition maintains ketosis in the individual.

### Claim 5 (depends on 1)

The method of claim 1 further comprising at least one amino acid.

### Claim 6 (depends on 1)

The method of claim 1 further comprising leucine.

### Claim 7 (depends on 1)

The method of claim 1 further comprising at least one of a fatty acid or ester of fatty acid.