# US 11,026,907 B2 · Azelaic acid gel, preparation method and application thereof > Agents: this data is available as JSON from the patentgrep API and MCP server — see https://patentgrep.com/llms.txt - Number: US 11,026,907 B2 - Document ID: US11026907B2 - Status: Granted - Kind: B2 - Application number: 16/960,025 - Filed: 2019-06-26 - Published: 2020-11-05 - Granted: 2021-06-08 - Earliest claimed: 2018-07-25 - Assignees: Chengdu Joy Young Biotechnology Co., Ltd. - Applicants: Chengdu Joy Young Biotechnology Co., Ltd. - Inventors: Guangji Wang - Web page: https://patentgrep.com/patent/US11026907B2 ## CPC - A61K 31/194: having two or more carboxyl groups, e.g. succinic, maleic or phthalic acid - A61K 9/0014: {Skin, i.e. galenical aspects of topical compositions (non-active ingredients are additionally classified in A61K47/00; A61K9/0009, A61K9/0021, A61K9/7015, A61K9/7023 take precedence; cosmetic preparations A61K8/00, A61Q; preparations for wound dressings or bandages A61L26/00)} - A61K 9/06: Ointments; Bases therefor; {Other semi-solid forms, e.g. creams, sticks, gels (composition of ointments, creams or gels A61K47/00)} - A61K 31/20: having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids - A61K 31/60: Salicylic acid; Derivatives thereof - A61K 47/10: Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers - A61K 47/32: Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers {, poly(meth)acrylates, or polyvinyl pyrrolidone} - A61P 17/10: Anti-acne agents - A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D) - A61P: SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS ## Abstract An azelaic acid gel, and a preparation method and an application thereof. The azelaic acid gel comprises the following components in percentage by weight: azelaic acid: 10-20%; salicylic acid: 0.5-2%; a polyacrylate cross-linked polymer-6: 1-3%; 1,3-propylene glycol: 60-74%; and the remaining part being water. The azelaic acid gel is used for preparing medicines for preventing or treating acnes. ## Claims ### Claim 1 An azelaic acid gel for preventing or treating acnes, comprising the following components by weight percentage: 10-20% of azelaic acid, 0.5-2% of salicylic acid, 1-3% of polyacrylate cross-linked polymer-6, 60-74% of 1,3-propylene glycol, and the remaining part being water. ### Claim 2 (depends on 1) The azelaic acid gel for preventing or treating acnes according to claim 1, wherein the azelaic acid gel comprises the following components by weight percentage: 12-18% of azelaic acid, 0.8-1.5% of salicylic acid, 1.5-2.5% of polyacrylate cross-linked polymer-6, 65-72% of 1,3-propylene glycol, and the remaining part being water. ### Claim 3 (depends on 1) The azelaic acid gel for preventing or treating acnes according to claim 1, wherein the azelaic acid gel comprises the following components by weight percentage: 15% of azelaic acid, 2% of polyacrylate cross-linked polymer-6, 1% of salicylic acid, 70% of 1,3-propylene glycol, and 12% of water. ### Claim 4 (depends on 1) The azelaic acid gel for preventing or treating acnes according to claim 1, wherein the water is deionized water. ### Claim 5 (depends on 1) A method for preparing the azelaic acid gel for preventing or treating acnes according to claim 1, comprising the following steps: a. uniformly dispersing polyacrylate cross-linked polymer-6 in 1,3-propylene glycol and then uniformly mixing with water to obtain solution A; b. uniformly dispersing azelaic acid in 1,3-propylene glycol and heating to 65-80° C. to obtain solution B; c. uniformly dispersing salicylic acid in 1,3-propylene glycol to obtain solution C; and d. mixing solution A, solution B and solution C, stirring at 55-65° C., and cooling to room temperature to obtain an azelaic acid gel. ### Claim 6 (depends on 1) A method, comprising: preparing a drug comprising the azelaic acid gel according to claim 1; and using the drug to treat or prevent acnes. ### Claim 7 (depends on 2) The azelaic acid gel for preventing or treating acnes according to claim 2, wherein the water is deionized water. ### Claim 8 (depends on 3) The azelaic acid gel for preventing or treating acnes according to claim 3, wherein the water is deionized water. ### Claim 9 (depends on 2) A method for preparing the azelaic acid gel for preventing or treating acnes according to claim 2, comprising the following steps: a. uniformly dispersing polyacrylate cross-linked polymer-6 in 1,3-propylene glycol and then uniformly mixing with water to obtain solution A; b. uniformly dispersing azelaic acid in 1,3-propylene glycol and heating to 65-80° C. to obtain solution B; c. uniformly dispersing salicylic acid in 1,3-propylene glycol to obtain solution C; and d. mixing solution A, solution B and solution C, stirring at 55-65° C., and cooling to room temperature to obtain an azelaic acid gel. ### Claim 10 (depends on 3) A method for preparing the azelaic acid gel for preventing or treating acnes according to claim 3, comprising the following steps: a. uniformly dispersing polyacrylate cross-linked polymer-6 in 1,3-propylene glycol and then uniformly mixing with water to obtain solution A; b. uniformly dispersing azelaic acid in 1,3-propylene glycol and heating to 65-80° C. to obtain solution B; c. uniformly dispersing salicylic acid in 1,3-propylene glycol to obtain solution C; and d. mixing solution A, solution B and solution C, stirring at 55-65° C., and cooling to room temperature to obtain an azelaic acid gel. ### Claim 11 (depends on 4) A method for preparing the azelaic acid gel for preventing or treating acnes according to claim 4, comprising the following steps: a. uniformly dispersing polyacrylate cross-linked polymer-6 in 1,3-propylene glycol and then uniformly mixing with water to obtain solution A; b. uniformly dispersing azelaic acid in 1,3-propylene glycol and heating to 65-80° C. to obtain solution B; c. uniformly dispersing salicylic acid in 1,3-propylene glycol to obtain solution C; and d. mixing solution A, solution B and solution C, stirring at 55-65° C., and cooling to room temperature to obtain an azelaic acid gel.