# US 11,026,880 B2 · Extract of passionflower seeds and cosmetic, pharmaceutical, dermatological and nutraceutical compositions comprising same > Agents: this data is available as JSON from the patentgrep API and MCP server — see https://patentgrep.com/llms.txt - Number: US 11,026,880 B2 - Document ID: US11026880B2 - Status: Granted - Kind: B2 - Application number: 14/652,449 - Filed: 2013-12-18 - Published: 2016-03-17 - Granted: 2021-06-08 - Earliest claimed: 2012-12-18 - Assignees: Laboratoires Expanscience - Applicants: Laboratoires Expanscience - Inventors: Philippe Msika; Sophie Leclere-Bienfait; Sebastien Debrock; Stephanie Bredif; Sebastien Garnier - Web page: https://patentgrep.com/patent/US11026880B2 ## CPC - A61K 8/97: from algae, fungi, lichens or plants; from derivatives thereof - A61K 8/60: Sugars; Derivatives thereof - A61K 8/645: {Proteins of vegetable origin; Derivatives or degradation products thereof} - A61K 36/185: Magnoliopsida (dicotyledons) - A61K 45/06: Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca - A61P 3/06: Antihyperlipidemics - A61P 9/00: Drugs for disorders of the cardiovascular system - A61P 9/14: Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers - A61P 17/00: Drugs for dermatological disorders - A61P 39/06: Free radical scavengers or antioxidants - A61Q 5/02: Preparations for cleaning the hair - A61Q 5/12: Preparations containing hair conditioners - A61Q 17/00: Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings - A61Q 17/04: Topical preparations for affording protection against sunlight or other radiation; Topical sun tanning preparations - A61Q 19/005: {Preparations for sensitive skin} - A61Q 19/007: {Preparations for dry skin} - A61Q 19/02: for chemically bleaching or whitening the skin - A61Q 19/06: for countering cellulitis - A61Q 19/08: Anti-ageing preparations - A61K 2236/15: involving mechanical treatment, e.g. chopping up, cutting or grinding - A61K 2236/19: involving fermentation using yeast, bacteria or both; enzymatic treatment - A61Q 7/00: Preparations for affecting hair growth - A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D) - A61P: SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS - A61Q: SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS ## Abstract The invention relates to a composition comprising an extract of passionflower seeds, and preferentially Passiflora edulis seeds. The composition is advantageously cosmetic, pharmaceutical, dermatological or nutraceutical. The subject matter of the invention is also a process for extracting an extract of passionflower seeds and preferentially Passiflora edulis seeds, and also the extract which can be obtained by means of said process. The invention also relates to such a composition or such an extract for use in the prevention or treatment of disorders or pathological conditions of the skin, of the mucous membranes or of the skin appendages, for use in the prevention or treatment of vascular disorders, for use for combating oxidative stress, or else for use in the prevention or treatment of adipose tissue modifications. Finally, the invention relates to a cosmetic care process for the skin, the skin appendages or the mucous membranes, with a view to improving, the condition thereof or the appearance thereof, consisting in administering such a composition or such an extract. ## Claims ### Claim 1 A cosmetic, dermatological and pharmaceutical composition comprising a peptide and sugar extract of passionflower seeds, as active agent, and a suitable excipient, wherein the peptide and sugar extract is obtained by enzymatic hydrolysis of passionflower seeds, in the presence of at least one acid protease and at least one carbohydrase, wherein the peptide and sugar extract comprises 20% to 70% by weight peptides and 20% to 60% by weight sugars. ### Claim 2 (depends on 1) The composition of claim 1, wherein the passionflower is Passiflora incarnata or Passiflora edulis. ### Claim 3 (depends on 1) The composition according to claim 1, wherein in the peptide and sugar extract the peptides have a size less than 3500 Da. ### Claim 4 (depends on 1) The composition according to claim 1, wherein in the peptide and sugar extract the weight ratio of peptides/sugars is greater than 0.75. ### Claim 5 (depends on 4) The composition according to claim 4, wherein the peptide and sugar extract comprises 30% to 65% by weight peptides. ### Claim 6 (depends on 4) The composition according to claim 4, wherein the peptide and sugar extract comprises typically 55% by weight peptides. ### Claim 7 (depends on 4) The composition according to claim 4, wherein the peptide and sugar extract comprises 30% to 55% by weight sugars. ### Claim 8 (depends on 4) The composition according to claim 4, wherein the peptide and sugar extract comprises typically 40% by weight sugars. ### Claim 9 (depends on 1) The composition according to claim 1, comprising 0.001% to 10% by weight of said peptide and sugar extract of passionflower seeds, the weight of the extract being expressed in dry extract, in relation to the total weight of the composition. ### Claim 10 (depends on 1) The composition according to claim 1, comprising 0.01% to 5% by weight of said peptide and sugar extract of passionflower seeds, the weight of the extract being expressed in dry extract, in relation to the total weight of the composition. ### Claim 11 (depends on 1) The composition according to claim 1, further comprising one other active agent, in addition to the peptide and sugar extract of passionflower seeds, said one other active agent being advantageously selected from: emollients, moisturizing active agents, keratin-synthesis activators, keratoregulators, keratolytics, agents that restructure the cutaneous barrier (activators of synthesis of cutaneous lipids), peroxisome proliferator-activated receptor (PPAR) agonists, RXR or LXR agonists, sebum-regulating agents, anti-irritant agents, soothing agents, anti-inflammatory agents, antioxidants and anti-aging agents, depigmenting or hypodepigmenting agents, pigmenting agents, lipolytic agents or lipogenesis inhibitors or anti-cellulite or reducing agents, inorganic or organic sun filters and screens, antifungal compounds, preservatives, antibacterial agents, prebiotics and probiotics, antibiotics, immunomodulators; plant extracts; and oxazolines. ### Claim 12 A process for preparing a peptide and sugar extract of passionflower seeds, comprising at least one enzymatic hydrolysis of passionflower seeds step in the presence of at least one “acid” protease and at least one carbohydase, wherein the peptide and sugar extract comprises 20% to 70% by weight peptides and 20% to 60% by weight sugars. ### Claim 13 (depends on 12) The process according to claim 12, wherein passionflower seeds are Passiflora incarnata seeds or Passiflora edulis seeds. ### Claim 14 (depends on 12) The process according to claim 12, comprising the following successive steps: a) dispersion in an aqueous phase of grinded passionflower seeds, then b) enzymatic treatment, by adding “said” at least one “acid” protease and at least one carbohydrase, of the aqueous dispersion obtained in step a), then c) if need be, heat treatment in order to denature the enzymes, and d) collection of the peptide and sugar extract at the conclusion of step b) or c). ### Claim 15 (depends on 14) The process according to claim 14, wherein the enzymatic treatment successively comprises a step b1) of adding a carbohydrase, then a step b2) of adding said at least one acid protease. ### Claim 16 (depends on 15) The process according to claim 15, wherein the enzymatic treatment successively comprises a step b1) of adding a carbohydrase, selected from pectinases, cellulases, arabanases, hemicellulases, xylanases and β-glucanases. ### Claim 17 (depends on 14) The process according to claim 14, wherein prior to step a) the seeds are defatted. ### Claim 18 (depends on 14) The process according to claim 14, comprising an additional step, between steps b), or if need be c), and d) of filtration or centrifugation, optionally followed by ultrafiltration, diafiltration or nanofiltration. ### Claim 19 (depends on 18) The process according to claim 18, comprising a step of 15 kDa ultrafiltration. ### Claim 20 A peptide and sugar extract of passionflower seeds obtained by a process comprising at least one enzymatic hydrolysis of passionflower seeds step in the presence of at least one “acid” protease and at least one carbohydase, wherein the peptide and sugar extract of passionflower seeds contains 20% to 70% by weight peptides and 20% to 60% by weight sugars. ### Claim 21 (depends on 20) A peptide and sugar extract according to claim 20, wherein the passionflower seeds are Passiflora incarnata seeds or Passiflora edulis seeds, advantageously Passiflora edulis seeds. ### Claim 22 (depends on 20) The extract according to claim 20, containing 30% to 65% by weight peptides and 30% to 55% by weight sugars. ### Claim 23 (depends on 20) The extract according to claim 20, containing typically 55% by weight pepteides and typically 40% by weight sugars. ### Claim 24 (depends on 20) A method for preventing and for treating: disorders or pathological conditions of the skin and/or the mucous, membranes and/or the skin appendages, vascular disorders, adipose tissue modifications, oxidative stress, comprising the administration to a person in need thereof of an extract according to claim 20. ### Claim 25 (depends on 1) A cosmetic care process for the skin and/or the skin appendages and/or the mucous membranes, with a view to improving the condition and/or appearance thereof, comprising administering a cosmetic composition as defined according to claim 1. ### Claim 26 (depends on 1) A method for preventing and for treating: disorders or pathological conditions of the skin and/or the mucous, membranes and/or the skin appendages, vascular disorders, adipose tissue modifications, oxidative stress, comprising the administration to a person in need thereof of a composition according to claim 1. ### Claim 27 (depends on 20) A cosmetic care process for the skin and/or the skin appendages and/or the mucous membranes, with a view to improving the condition and/or appearance thereof, comprising administering an extract as defined according to claim 20. ### Claim 28 (depends on 20) A cosmetic care process for the skin and/or the skin appendages and/or the mucous membranes, with a view to improving the condition and/or appearance thereof, comprising administering an extract as defined according to claim 20. ### Claim 29 (depends on 4) The composition according to claim 4, wherein in the peptide and sugar extract the weight ratio of peptides/sugars is between 1 and 2.