# US 11,026,879 B2 · Dispersion of drops of a first phase, dispersed in a second phase substantially immiscible with the first phase > Agents: this data is available as JSON from the patentgrep API and MCP server — see https://patentgrep.com/llms.txt - Number: US 11,026,879 B2 - Document ID: US11026879B2 - Status: Granted - Kind: B2 - Application number: 16/384,848 - Filed: 2019-04-15 - Published: 2019-08-08 - Granted: 2021-06-08 - Earliest claimed: 2011-08-03 - Assignees: Capsum - Applicants: Capsum - Inventors: Mathieu Goutayer; Jerome Bibette - Web page: https://patentgrep.com/patent/US11026879B2 ## CPC - A61K 8/8147: {Homopolymers or copolymers of acids; Metal or ammonium salts thereof, e.g. crotonic acid, (meth)acrylic acid; Compositions of derivatives of such polymers} - A23D 7/0053: {Compositions other than spreads} - A23D 7/02: characterised by the production or working-up {(kneading, forming A01J21/00)} - A23P 10/30: Encapsulation of particles, e.g. foodstuff additives - A61K 8/062: {Oil-in-water emulsions} - A61K 8/11: Encapsulated compositions - A61K 8/31: Hydrocarbons - A61K 8/891: saturated, e.g. dimethicone, phenyl trimethicone, C24-C28 methicone or stearyl dimethicone - A61K 8/922: {of vegetable origin} - A61K 9/10: Dispersions; Emulsions - A61K 9/5026: {obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates} - A61K 47/32: Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers {, poly(meth)acrylates, or polyvinyl pyrrolidone} - A61Q 19/00: Preparations for care of the skin - B01J 13/10: Complex coacervation, i.e. interaction of oppositely charged particles - A61K 47/34: Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers (A61K47/10 takes precedence) - A61K 2800/412: Microsized, i.e. having sizes between 0.1 and 100 microns - A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D) - A23D: EDIBLE OILS OR FATS, e.g. MARGARINES, SHORTENINGS OR COOKING OILS (preservation thereof A23B20/00; production, refinement or preservation of animal or vegetable fats or oils C11B, C11C) - A23P: SHAPING OR WORKING OF FOODSTUFFS, NOT FULLY COVERED BY A SINGLE OTHER SUBCLASS - A61Q: SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS - B01J: CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS ## Abstract The invention deals with a dispersion of drops of a first phase in a second phase substantially immiscible with the first phase, the solubility of the first phase in the second phase being less than 5% by mass. Each drop includes a core formed with a first phase and a shell formed with a coacervate layer interposed between the first phase and the second phase. The coacervate layer comprises a first precursor polymer of the coacervate and a second precursor polymer of the coacervate, one of the first phase and of the second phase is aqueous, and the other of the first phase and of the second phase is oily. ## Claims ### Claim 1 A dispersion of drops of a first phase in a second phase, the solubility of the first phase in the second phase being less than 5% by mass, each drop including a core formed with the first phase and a shell formed with a coacervate layer interposed between the first phase and the second phase, wherein the coacervate layer comprises a first precursor polymer of the coacervate and a second precursor polymer of the coacervate, one of the first phase and of the second phase being aqueous, and the other of the first phase and of the second phase being oily, wherein one of the first precursor and of the second precursor comprises a lipophilic polymer that is capable of being ionized upon contact with an aqueous phase, and wherein the other of the first precursor polymer and of the second precursor polymer comprises a hydrophilic polymer capable of being ionized. ### Claim 2 (depends on 1) The dispersion according to claim 1, wherein the drops have diameter of more than 500 micrometers and less than 3,000 microns. ### Claim 3 (depends on 1) The dispersion according to claim 1, wherein the shell has a thickness of less than 1,000 nanometers. ### Claim 4 (depends on 1) The dispersion according to claim 1, wherein the first precursor polymer of the coacervate is a first polymer which may be ionized in order to have a first charge, and the second precursor polymer of the coacervate is a second polymer which may be ionized in order to have a second charge opposite to the first charge. ### Claim 5 (depends on 1) The dispersion according to claim 1, wherein a perfuming agent is placed in one of the first phase and the second phase. ### Claim 6 (depends on 1) The dispersion according to claim 1, wherein each drop of the first phase has a deformation before breaking of more than 50%, the deformation before breaking being characterized by the gamma coefficient calculated through the equation: γ = A MAX - A INIT A MAX , AMAX being the apparent area of the drop just before its breaking and AINIT being the initially measured apparent area of the drop. ### Claim 7 (depends on 1) The dispersion according to claim 1, wherein the mass content of drops of the first phase in the dispersion is comprised between 0.1% by mass and 70% by mass. ### Claim 8 (depends on 1) A cosmetic composition comprising the dispersion according to claim 1. ### Claim 9 (depends on 1) The dispersion according to claim 1, wherein the drops have a diameter of between 800 microns and 2,000 microns. ### Claim 10 (depends on 1) The dispersion according to claim 1, wherein the shell has a thickness of between 1 nanometer and 500 nanometers. ### Claim 11 (depends on 1) The dispersion according to claim 1, wherein a perfuming agent is placed in the oily phase. ### Claim 12 (depends on 1) The dispersion according to claim 1, wherein each drop of the first phase has a deformation before breaking of more than 100%, the deformation before breaking being characterized by the gamma coefficient calculated through the equation: γ = A MAX - A INIT A MAX , AMAX being the apparent area of the drop just before its breaking and AINIT being the initially measured apparent area of the drop. ### Claim 13 (depends on 1) The dispersion according to claim 1, wherein the mass content of drops of first phase in the dispersion is comprised between 3% by mass and 50% by mass. ### Claim 14 (depends on 6) The dispersion according to claim 6, wherein each drop of the first phase has a deformation before breaking of more than 50%, the deformation before breaking being characterized by the gamma coefficient calculated through the equation: γ = A MAX - A INIT A MAX , AMAX being the apparent area of the drop 50 microseconds before the breaking of the drop and AINIT being the initially measured apparent area of the drop. ### Claim 15 (depends on 12) The dispersion according to claim 12, wherein each drop of the first phase has a deformation before breaking of more than 100%, the deformation before breaking being characterized by the gamma coefficient calculated through the equation: γ = A MAX - A INIT A MAX , AMAX being the apparent area of the drop 50 microseconds before the breaking of the drop and AINIT being the initially measured apparent area of the drop. ### Claim 16 (depends on 1) The dispersion according to claim 1, wherein the lipophilic polymer which may be ionized in contact with an aqueous phase is a polymer containing a silicone and containing a functional group which may be ionized. ### Claim 17 (depends on 1) The dispersion according to claim 1, wherein each drop comprises, by mass based on the mass of the drop: from 0.05% to 10% of a polymer P1 of the anionic and hydrophilic type, and from 0.05% to 10% of a polymer P2 of the cationic and lipophilic type. ### Claim 18 (depends on 1) The dispersion according to claim 1, wherein each drop comprises, by mass based on the mass of the drop: from 0.05% to 10% of a polymer P1 of the cationic and hydrophilic type, and from 0.05% to 10% of a polymer P2 of the anionic and lipophilic type.