# US 11,026,876 B2 · Composition for improving skin condition comprising chemokines

> Agents: this data is available as JSON from the patentgrep API and MCP server — see https://patentgrep.com/llms.txt

- Number: US 11,026,876 B2
- Document ID: US11026876B2
- Status: Granted
- Kind: B2
- Application number: 16/324,580
- Filed: 2017-07-28
- Published: 2019-06-13
- Granted: 2021-06-08
- Earliest claimed: 2016-08-10
- Assignees: Tego Science Inc.
- Applicants: Tego Science Inc.
- Inventors: Saewha Jeon; Yun Hee Kim; Jik Hyon Han; Hyun Ah Moon
- Web page: https://patentgrep.com/patent/US11026876B2

## CPC

- A61K 8/64: Proteins; Peptides; Derivatives or degradation products thereof
- A61K 8/65: Collagen; Gelatin; Keratin; Derivatives or degradation products thereof
- A61K 8/733: {Alginic acid; Salts thereof}
- A61K 8/735: {Mucopolysaccharides, e.g. hyaluronic acid; Derivatives thereof}
- A61K 38/195: {Chemokines, e.g. RANTES}
- A61K 47/36: Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
- A61Q 19/00: Preparations for care of the skin
- A61Q 19/007: {Preparations for dry skin}
- A61Q 19/02: for chemically bleaching or whitening the skin
- A61Q 19/08: Anti-ageing preparations
- C07K 14/521: {Chemokines}
- A61K 2800/5922: At least two compounds being classified in the same subclass of A61K8/18
- A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D)
- A61Q: SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- C07K: PEPTIDES (peptides in foodstuffs A23; obtaining protein compositions for foodstuffs, working-up proteins for foodstuffs A23J; preparations for medicinal purposes A61K; peptides containing beta-lactam rings C07D; cyclic dipeptides not having in their molecule any other peptide link than those which form their ring, e.g. piperazine-2,5-diones, C07D; ergot alkaloids of the cyclic peptide type C07D519/02; macromolecular compounds having statistically distributed amino acid units in their molecules, i.e. when the preparation does not provide for a specific; but for a random sequence of the amino acid units, homopolyamides and block copolyamides derived from amino acids C08G69/00; macromolecular products derived from proteins C08H1/00; preparation of glue or gelatine C09H; single cell proteins, enzymes C12N; genetic engineering processes for obtaining peptides C12N15/00; compositions for measuring or testing processes involving enzymes C12Q; investigation or analysis of biological material G01N33/00)

## Abstract

The present invention relates to a composition for skin improvement containing at least one chemokine selected from the group consisting of B lymphocyte chemoattractant (BLC), also known as C-X-C motif ligand 13 (CXCL13), and thymus-expressed chemokine (TECK), also known as C-C motif ligand 25 (CCL25), as an active ingredient. Since the BLC (CXCL13) and TECK (CCL25) of the present invention increase the expression of proliferation marker Ki-67 and collagen IV, which are proteins concerning skin regeneration and skin elasticity, and exhibit excellent melanin-reducing and wound-healing effects and the ability to induce chemotaxis of keratinocytes, they can be applied in a cosmetic composition for skin improvement.

## Claims

### Claim 1

A method for skin improvement comprising applying a cosmetic composition comprising at least one active ingredient selected from the group consisting of a B lymphocyte chemoattractant (BLC) and a thymus-expressed chemokine (TECK) to skin for skin improvement.

### Claim 2 (depends on 1)

The method of claim 1, wherein the cosmetic composition further comprises at least one polymer selected from the group consisting of alginates, collagens, hyaluronic acids, and gelatins.

### Claim 3 (depends on 1)

The method of claim 1, wherein the cosmetic composition comprises the B lymphocyte chemoattractant (BLC) or thymus-expressed chemokine (TECK) in an amount of 0.0000001 to 10 parts by weight with respect to 100 parts by weight of a total weight of the cosmetic composition.

### Claim 4 (depends on 1)

The method of claim 1, wherein said skin improvement is skin regeneration.

### Claim 5 (depends on 1)

The method of claim 1, wherein the skin improvement is skin elasticity improvement.

### Claim 6 (depends on 1)

The method of claim 1, wherein the skin improvement is wrinkle prevention or improvement.

### Claim 7 (depends on 1)

The method of claim 1, wherein the skin improvement is skin moisturization.

### Claim 8 (depends on 1)

The method of claim 1, wherein the skin improvement is skin whitening.

### Claim 9 (depends on 1)

The method of claim 1, wherein the skin improvement is anti-inflammation.