# US 11,026,871 B2 · Oral care compositions and methods of using the compositions

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- Number: US 11,026,871 B2
- Document ID: US11026871B2
- Status: Granted
- Kind: B2
- Application number: 15/766,531
- Filed: 2015-10-08
- Published: 2018-10-04
- Granted: 2021-06-08
- Earliest claimed: 2015-10-08
- Assignees: Colgate-Palmolive Company
- Applicants: Colgate-Palmolive Company
- Inventors: Aarti Rege; Richard Sullivan; David Suriano
- Web page: https://patentgrep.com/patent/US11026871B2

## CPC

- A61K 8/27: Zinc; Compounds thereof
- A61K 8/0204: {Specific forms not provided for by any of groups A61K8/0208 - A61K8/14}
- A61K 8/042: {Gels}
- A61K 8/19: containing inorganic ingredients
- A61K 8/21: Fluorides; Derivatives thereof
- A61K 8/24: Phosphorous; Compounds thereof
- A61K 8/25: Silicon; Compounds thereof
- A61P 1/02: Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
- A61Q 11/00: Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
- A61K 2800/28: Rubbing or scrubbing compositions; Peeling or abrasive compositions; Containing exfoliants
- A61K 2800/74: Biological properties of particular ingredients
- A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D)
- A61P: SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61Q: SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS

## Abstract

An oral care composition is disclosed. The composition comprises zinc phosphate and a silicate compound comprising a metallic element that in cationic form is capable of reducing tooth enamel erosion. The zinc phosphate is added to the oral care composition as a preformed salt. Methods of administering the oral care compositions to subjects in need thereof are also disclosed.

## Claims

### Claim 1

An oral care composition, comprising:
zinc phosphate, wherein the zinc phosphate is added to the oral care composition as a preformed salt, and wherein the zinc phosphate is in an amount of 1% by weight, relative to the weight of the oral care composition; and
a silicate compound comprising calcium silicate in an amount of 3% by weight, relative to the weight of the oral care composition, wherein the amount of calcium silicate is effective to reduce tooth enamel erosion.

### Claim 2 (depends on 1)

The oral care composition of claim 1, wherein the oral care composition comprises an abrasive.

### Claim 3 (depends on 1)

The oral care composition of claim 1, comprising one or more humectants, and one or more surfactants.

### Claim 4 (depends on 1)

The oral care composition of claim 1, further comprising an effective amount of a fluoride ion source.

### Claim 5 (depends on 1)

The oral care composition of claim 1, further comprising a basic amino acid in free or orally acceptable salt form.

### Claim 6 (depends on 1)

The oral care composition of claim 1, further comprising an effective amount of one or more alkali phosphate salts.

### Claim 7 (depends on 1)

The oral care composition of claim 1, further comprising a whitening agent.

### Claim 8 (depends on 1)

The oral care composition of claim 1, wherein the oral care composition is a dentifrice.

### Claim 9 (depends on 1)

The oral care composition of claim 1, further comprising from 1 to 8% by weight alkali phosphate salts selected from sodium phosphate dibasic, potassium phosphate dibasic, dicalcium phosphate dihydrate, tetrasodium pyrophosphate, tetrapotassium pyrophosphate, calcium pyrophosphate, sodium tripolyphosphate, and mixtures of any two or more of these;
from 0.05 to 0.5% by weight fluoride; and
a silica abrasive dentifrice base.

### Claim 10 (depends on 1)

The oral care composition of claim 1, wherein the oral care composition is a gel.

### Claim 11 (depends on 1)

The oral care composition of claim 1, wherein the oral care composition is a lozenge or mint.

### Claim 12 (depends on 1)

The oral care composition of claim 1, wherein the oral care composition is a chewing gum.

### Claim 13 (depends on 1)

The oral care composition of claim 1, further comprising an effective amount of one or more antimicrobial agents.

### Claim 14 (depends on 1)

A method of treating or reducing dental enamel erosion comprising administering a composition according to claim 1 to the oral cavity of a subject in need thereof.

### Claim 15 (depends on 4)

The oral care composition of claim 4, wherein the fluoride source is selected from the group consisting of stannous fluoride, sodium fluoride, potassium fluoride, sodium monofluorophosphate, sodium fluoro silicate, ammonium fluorosilicate, amine fluoride, ammonium fluoride, and combinations thereof.