# US 11,026,868 B2 · Patch for tooth attachment able to be removed by tooth brushing

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- Number: US 11,026,868 B2
- Document ID: US11026868B2
- Status: Granted
- Kind: B2
- Application number: 16/902,892
- Filed: 2020-06-16
- Published: 2020-10-01
- Granted: 2021-06-08
- Earliest claimed: 2015-10-06
- Assignees: LG Household & Health Care Ltd.
- Applicants: LG Household & Health Care Ltd.
- Inventors: Jong-Hoon Kim; Jae-Hyun Ahn; Kwang-Ho Oh; In-Ho Lee; Woo-Sun Shim
- Web page: https://patentgrep.com/patent/US11026868B2

## CPC

- A61K 8/0208: {Tissues; Wipes; Patches}
- A61K 8/02: characterised by special physical form
- A61K 8/19: containing inorganic ingredients
- A61K 8/22: Peroxides; Oxygen; Ozone
- A61K 8/24: Phosphorous; Compounds thereof
- A61K 8/34: Alcohols
- A61K 8/345: {containing more than one hydroxy group}
- A61K 8/4973: {with oxygen as the only hetero atom}
- A61K 8/72: containing organic macromolecular compounds
- A61K 8/73: Polysaccharides
- A61K 8/731: {Cellulose; Quaternized cellulose derivatives}
- A61K 8/8176: {Homopolymers of N-vinyl-pyrrolidones. Compositions of derivatives of such polymers}
- A61K 8/922: {of vegetable origin}
- A61K 8/97: from algae, fungi, lichens or plants; from derivatives thereof
- A61K 8/9789: Magnoliopsida [dicotyledons]
- A61K 8/9794: Liliopsida [monocotyledons]
- A61K 9/0056: {Mouth soluble or dispersible forms; Suckable, eatable, chewable coherent forms; Forms rapidly disintegrating in the mouth; Lozenges; Lollipops; Bite capsules; Baked products; Baits or other oral forms for animals}
- A61K 9/006: {Oral mucosa, e.g. mucoadhesive forms, sublingual droplets; Buccal patches or films; Buccal sprays}
- A61K 9/0063: {Periodont}
- A61K 9/7007: {Drug-containing films, membranes or sheets (A61K9/0041, A61K9/0043, A61K9/006, A61K9/0063 take precedence)}
- A61K 9/7053: {obtained by reactions only involving carbon to carbon unsaturated bonds, e.g. polyvinyl, polyisobutylene, polystyrene}
- A61K 33/40: Peroxides
- A61K 47/32: Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers {, poly(meth)acrylates, or polyvinyl pyrrolidone}
- A61K 47/38: Cellulose; Derivatives thereof
- A61Q 11/00: Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
- A61Q 11/02: Preparations for deodorising, bleaching or disinfecting dentures
- A61K 2800/92: Oral administration
- A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D)
- A61Q: SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS

## Abstract

The present invention provides a patch for attaching to teeth or a surrounding part of teeth, and the patch can be easily removed by tooth brushing alone.

## Claims

### Claim 1

A method for using a patch for attaching to teeth or a surrounding part of teeth,
comprising:
attaching a patch to teeth or a surrounding part of teeth, and
removing the patch after moisture absorption by tooth brushing,
wherein the patch comprises:
a drug layer including a drug component; and
a backing layer which is positioned on one side of the drug layer,
wherein the backing layer includes a water-soluble polymer and water-insoluble polymer,
wherein the water-insoluble polymer is at least one selected from the group consisting of cellulose acetate phthalate, shellac, polyvinyl acetate, ethyl cellulose, polymethyl methacrylate, methacryloyl ethyl betaine/methacrylate copolymer, methacrylic acid copolymer and aminoalkyl methacrylate copolymer, and
the water-soluble polymer is at least one selected from the group consisting of polyalkyl vinyl ether-maleic acid copolymer (PVM/MA copolymer), polyvinyl alcohol, polyacrylic acid, Poloxamer 407, polyethyleneoxide (Polyox), polyvinyl pyrrolidone-vinyl acetate copolymer (PVP/VA copolymer), polyvinyl pyrrolidone (PVP), polyquaternium-11, polyquaternium-39, carboxypolymethylene (Carbomer), hydroxypropyl methyl cellulose, hydroxyethyl cellulose, hydroxypropyl cellulose, gelatin and sodium alginate, and
wherein the patch backing layer is capable of being degraded, dispersed into particles and detached by tooth brushing.

### Claim 2 (depends on 1)

The method of claim 1, wherein the backing layer has tensile strength reduction rate of 60% to 95%, compared to before moisture absorption.

### Claim 3 (depends on 1)

The method of claim 1, the tensile strength of the backing layer of the patch, which is measured in a state that moisture is sufficiently absorbed so that the moisture content rate does not change for 10 sec, and measured at an environment of temperature of 25° C. using Zwick, DE/1494 universal testing machine at a rate of 0.1 mm/s, is reduced by 50% or more, compared to before moisture absorption.

### Claim 4 (depends on 1)

The method of claim 1, wherein a weight ratio of the water-soluble polymer and the water-insoluble polymer included in the backing layer (water-soluble polymer: water-insoluble polymer) is 1:4 to 4:1.

### Claim 5 (depends on 1)

The method of claim 1, wherein the water-insoluble polymer is ethyl cellulose.

### Claim 6 (depends on 1)

The method of claim 1, wherein the drug layer comprises at least one selected from the group consisting of an ingredient for whitening teeth, an ingredient for preventing or improving sensitive teeth, an ingredient for preventing cavities, and an ingredient for preventing periodontal disease.

### Claim 7 (depends on 6)

The method of claim 6,
wherein the ingredient for whitening teeth is:
at least one peroxide selected from the group consisting of hydrogen peroxide, carbamide peroxide, calcium peroxide, sodium percarbonate, sodium perborate, tetrasodium pyrophosphate peroxidate and a mixture thereof;
at least one polyphosphate selected from the group consisting of tetrasodium pyrophosphate (TSPP), sodium acid pyrophosphate (SAPP), sodium hexametaphosphate (SHMP), sodium tripolyphosphate (STP), sodium potassium tripolyphosphate (SKTP), tetrapotassium pyrophosphate (TKPP), ultra-metaphosphate as ultra-phosphate, acidic sodium polyphosphate and a mixture thereof;
wherein the ingredient for preventing or improving sensitive teeth or cavities is at least one selected from the group consisting of strontium chloride, calcium carbonate, sodium citrate, sodium fluoride, silica, hydroxyapatite, potassium nitrate and potassium phosphate,
wherein the ingredient for preventing periodontal disease is at least one selected from the group consisting of bamboo salt, titrated Extract of Zea Mays L. unsaponifiable fraction, policresulen, tetracycline, chlorhexidine gluconate, cetyl pyridinium chloride, sanguinarine, triclosan, Magnoliae Cortex, Centella Asiatica, Chamomile, Rhatany, Myrrha, Mori Cortex Radicis, Cimicifugae Rhizoma, Green tea, Glycyrrhizae Radix et Rhizoma, Scutellariae Radix, Taraxaci Herba and Lonicerae Flos.

### Claim 8

A method for using a patch for attaching to teeth or a surrounding part of teeth, comprising:
attaching a patch to teeth or a surrounding part of teeth, and
removing the patch after moisture absorption by tooth brushing,
wherein the patch comprises:
a drug layer attached to teeth or a surrounding part of teeth; and
a backing layer which is positioned on one side of the drug layer,
wherein the patch backing layer is capable of being degraded, dispersed into particles and detached by tooth brushing,
wherein the backing layer has a static contact angle which varies over time.

### Claim 9 (depends on 8)

The method of claim 8, wherein the static contact angle varies from 13° to 50° over 10 sec to 300 sec when measured at a temperature of 20° C.

### Claim 10

A method for using a patch for attaching to teeth or a surrounding part of teeth, comprising:
attaching a patch to teeth or a surrounding part of teeth, and
removing the patch after moisture absorption by tooth brushing,
wherein the patch comprises
a drug layer in contact with teeth or a surrounding part of teeth; and
a backing layer positioned on one side of the drug layer,
wherein the backing layer is capable of being degraded, and detached by tooth brushing,
wherein the backing layer includes a polymer having solubility parameter (δ1) of 5 (MPa)1/2 to 22 (MPa)1/2; and a polymer having solubility parameter (δ2) of 23.5 (MPa)1/2 to 40 (MPa)1/2.

### Claim 11 (depends on 10)

The method of claim 10, wherein the polymer having solubility parameter (δ2) of 23.5 (MPa)1/2 to 40 (MPa)1/2 is any one selected from polyalkyl vinyl ether-maleic acid copolymer, polyvinyl alcohol, polyacrylic acid, Poloxamer, polyethyleneoxide, polyvinyl pyrrolidone-vinyl acetate copolymer, polyvinyl pyrrolidone, polyquaternium-11, polyquaternium-39, carboxypolymethylene, hydroxypropyl methyl cellulose, hydroxyethyl cellulose, hydroxypropyl cellulose, gelatin, sodium alginate and a mixture thereof.

### Claim 12 (depends on 10)

The method of claim 10, wherein a weight ratio of the polymer having solubility parameter (δ1) of 5 (MPa)1/2 to 22 (MPa)1/2 and the polymer having solubility parameter (δ2) of 23.5 (MPa)1/2 to 40 (MPa)1/2 included in the backing layer is 1:0.2 to 4.0.

### Claim 13 (depends on 1)

The method of claim 1, wherein the backing layer includes a breakable portion.

### Claim 14 (depends on 13)

The method of claim 13, wherein the breakable portion includes prominence and depression or bubbles.

### Claim 15 (depends on 14)

The method of claim 14, wherein the prominence and depression have a concave portion in a depth of more than 0 μm and 30 μm or less based on a convex portion.

### Claim 16 (depends on 14)

The method of claim 14, wherein the prominence and depression have a concave portion in a width of more than 0 mm and 0.1 mm or less.

### Claim 17 (depends on 8)

The method of claim 8, wherein the backing layer of the patch includes a water-soluble polymer and a water-insoluble polymer.