# US 11,026,839 B2 · Treatment to improve adhesive properties of corneal implant > Agents: this data is available as JSON from the patentgrep API and MCP server — see https://patentgrep.com/llms.txt - Number: US 11,026,839 B2 - Document ID: US11026839B2 - Status: Granted - Kind: B2 - Application number: 17/147,486 - Filed: 2021-01-13 - Published: 2021-05-06 - Granted: 2021-06-08 - Earliest claimed: 2018-01-08 - Assignees: EyeYon Medical Ltd. - Applicants: EyeYon Medical Ltd. - Inventors: Ofer Daphna; Nahum Ferera; Dmitry Dubson - Web page: https://patentgrep.com/patent/US11026839B2 ## CPC - A61F 9/00825: {for photodisruption} - A61F 2/0077: {Special surfaces of prostheses, e.g. for improving ingrowth (A61F2/30767 takes precedence)} - A61F 2/142: {Cornea, e.g. artificial corneae, keratoprostheses or corneal implants for repair of defective corneal tissue} - A61F 2/145: {Corneal inlays, onlays, or lenses for refractive correction} - A61F 2/1451: {Inlays or onlays} - A61F 2002/0081: {directly machined on the prosthetic surface, e.g. holes, grooves (A61F2/30771 takes precedence)} - A61F 2009/00853: {Laser thermal keratoplasty or radial keratotomy} - A61F 2009/00872: {Cornea} - A61F 2240/001: Designing or manufacturing processes - B23K 26/352: for surface treatment - B23K 2103/42: {Plastics other than composite materials} - B29C 71/02: Thermal after-treatment {(B29C71/0063 and B29C71/0072 take precedence)} - B29C 71/04: by wave energy or particle radiation {, e.g. for curing or vulcanising preformed articles (during moulding, e.g. in a mould B29C35/08)} - B29L 2031/7532: {Artificial members, protheses} - A61F: FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS (dental prosthetics A61C) - B23K: SOLDERING OR UNSOLDERING; WELDING; CLADDING OR PLATING BY SOLDERING OR WELDING; CUTTING BY APPLYING HEAT LOCALLY, e.g. FLAME CUTTING; WORKING BY LASER BEAM - B29C: SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING (making preforms B29B11/00; making laminated products by combining previously unconnected layers which become one product whose layers will remain together B32B37/00 - B32B41/00) - B29L: INDEXING SCHEME ASSOCIATED WITH SUBCLASS B29C, RELATING TO PARTICULAR ARTICLES ## Abstract A method is described of improving adhesion of an ocular implant to corneal tissue by forming an implant adhesive layer on the ocular implant, the implant adhesive layer having greater adhesive strength than a rest of the implant or by forming a corneal adhesive layer on a posterior surface of a posterior portion of the corneal tissue, the corneal adhesive layer having greater adhesive strength than a rest of the corneal tissue. ## Claims ### Claim 1 A method for preparing an implant for attachment to a posterior surface of the cornea, comprising: providing a corneal copolymer implant comprising the monomer 2-hydroxyethyl methacrylate and having an anterior surface and a posterior surface, and exposing at least the anterior surface of the implant to a treatment that improves adhesion between the implant and the cornea. ### Claim 2 (depends on 1) The method of claim 1 wherein the implant comprises a barrier to water. ### Claim 3 (depends on 1) The method of claim 1 wherein the implant has a dome shape. ### Claim 4 (depends on 1) The method of claim 1 wherein the treatment is a member selected from the group consisting of application of chemicals, heat, laser energy, flame, plasma and electric discharge. ### Claim 5 (depends on 4) The method of claim 4 which comprises applying laser energy from a Nd:YAG laser. ### Claim 6 (depends on 4) The method of claim 4 which comprises applying laser energy from a Yb:YAG laser. ### Claim 7 (depends on 1) The method of claim 1 wherein the treatment forms an adhesive layer on the anterior surface of the implant. ### Claim 8 (depends on 1) The method of claim 1 wherein the treatment comprises applying plasma and oxygen to at least the anterior surface of the implant. ### Claim 9 (depends on 1) The method of claim 1 wherein the implant comprises a member selected from the group consisting of hyaluronic acid, and the potassium and sodium salts thereof. ### Claim 10 (depends on 1) The method of claim 1 wherein the implant comprises pockets, depressions or protrusions on the anterior surface or the posterior surface. ### Claim 11 A method for making an ocular implant which comprises providing a dome-shaped implant comprising PMMA or Poly HEMA and applying laser energy to at least an anterior surface of said implant to configured said implant for attachment to a posterior surface of the cornea, said anterior surface being an adhesive surface for attaching the implant to the posterior surface of the cornea. ### Claim 12 A method for making an ocular implant which comprises providing a transparent dome-shaped implant having an anterior surface and a posterior surface, the implant comprising PMMA or Poly HEMA and treating at least one surface of the implant to improve adhesion between the implant and a posterior surface of a cornea. ### Claim 13 (depends on 12) The method of claim 12 wherein the treatment is a member selected from the group consisting of application of chemicals, heat, laser energy, flame, plasma and electric discharge. ### Claim 14 (depends on 13) The method of claim 13 wherein the treatment comprises application of laser energy to the implant. ### Claim 15 (depends on 13) The method of claim 13 wherein the treatment comprises application of chemicals to the implant. ### Claim 16 (depends on 14) The method of claim 14 which comprises applying laser energy to the anterior surface of the implant. ### Claim 17 (depends on 12) The method of claim 12 wherein the at least one surface is the anterior surface. ### Claim 18 (depends on 17) The method of claim 17, wherein the treating step comprises a physical treatment of the anterior surface. ### Claim 19 A method comprising: improving adhesion of an external surface of an ocular implant which is made of a polymeric material by making a change to said external surface that changes a chemical feature of said polymeric material which improves adhesion of said external surface to a posterior surface of a cornea. ### Claim 20 (depends on 19) The method of claim 19, wherein said change to said external surface comprises creation of hydrogen bonds. ### Claim 21 (depends on 19) The method of claim 19, wherein said polymeric material comprises a partially hydrolyzed polymeric material. ### Claim 22 (depends on 19) The method of claim 19, wherein said polymeric material comprises a methacrylic polymer. ### Claim 23 (depends on 19) The method of claim 19, wherein said polymeric material comprises a hydroxyethyl methacrylate. ### Claim 24 (depends on 19) The method of claim 19, wherein said polymeric material comprises a methylmethacrylate. ### Claim 25 (depends on 19) The method of claim 19, further comprising implanting said ocular implant against a posterior surface of a cornea, wherein said external surface adheres to the posterior surface of the cornea. ### Claim 26 (depends on 25) The method of claim 25, further comprising using said ocular implant as a water barrier to treat corneal edema.