# US 11,026,729 B2 · Methods, devices, and systems for blood flow > Agents: this data is available as JSON from the patentgrep API and MCP server — see https://patentgrep.com/llms.txt - Number: US 11,026,729 B2 - Document ID: US11026729B2 - Status: Granted - Kind: B2 - Application number: 16/837,533 - Filed: 2020-04-01 - Published: 2020-07-16 - Granted: 2021-06-08 - Earliest claimed: 2016-05-06 - Assignees: Medos International Sarl - Applicants: Medos International Sarl - Inventors: Gregory R. Whittaker; Benjamin Cleveland; Julia Hwang; David B. Spenciner; William R. Parrish; Mehmet Z. Sengun; Reagan A. Theis - Web page: https://patentgrep.com/patent/US11026729B2 ## CPC - A61B 17/846: {Nails or pins, i.e. anchors without movable parts, holding by friction only, with or without structured surface (A61B17/72, A61B17/86 take precedence)} - A61L 31/16: Biologically active materials, e.g. therapeutic substances {(A61L31/047 takes precedence)} - A61B 17/0401: {Suture anchors, buttons or pledgets, i.e. means for attaching sutures to bone, cartilage or soft tissue; Instruments for applying or removing suture anchors (A61B17/0642 takes precedence; fixation devices for tendons or ligaments A61F2/0811)} - A61L 27/28: Materials for coating prostheses - A61L 27/34: Macromolecular materials - A61L 27/58: Materials at least partially resorbable by the body - A61M 25/0043: {characterised by structural features} - A61B 2017/00004: {(bio)absorbable, (bio)resorbable or resorptive} - A61B 2017/0412: {having anchoring barbs or pins extending outwardly from suture anchor body} - A61B 2017/044: {with a threaded shaft, e.g. screws} - A61B 2017/0445: {cannulated, e.g. with a longitudinal through-hole for passage of an instrument} - A61B 2017/045: {snug fit within the anchor} - A61B 2017/0458: {Longitudinal through hole, e.g. suture blocked by a distal suture knot} - A61B 2017/561: {Implants with special means for releasing a drug} - A61F 2/0811: {Fixation devices for tendons or ligaments} - A61L 2300/42: Anti-thrombotic agents, anticoagulants, anti-platelet agents - A61L 2430/02: for reconstruction of bones; weight-bearing implants - A61M 2025/0057: {Catheters delivering medicament other than through a conventional lumen, e.g. porous walls or hydrogel coatings} - A61B: DIAGNOSIS; SURGERY; IDENTIFICATION (usefulness limited to only animals A61D) - A61L: METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES (preservation of bodies or disinfecting characterised by the agents employed A01N; preserving, e.g. sterilising, food or foodstuffs A23; preparations for medical, dental or toiletry purposes A61K) - A61M: DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY (introducing media into or onto the bodies of animals A61D7/00; means for inserting tampons A61F13/26; devices for administering food or medicines orally A61J; containers for collecting, storing or administering blood or medical fluids A61J1/05); DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY (surgery A61B; chemical aspects of surgical articles A61L); DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR {(Electrotherapy, e.g. producing anaesthesia by the use of alternating or intermittent currents A61N1/36021)} - A61F: FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS (dental prosthetics A61C) ## Abstract Various exemplary methods, systems, and devices for blood flow are provided. In general, an implant can be configured to be implanted in bone and to delay clotting of blood flowing from the bone. The implant can include an anti-coagulation agent to delay the clotting of the blood. The anti-coagulation agent can be a coating on the implant, can be natural to a material forming the implant, or can be impregnated into a material forming the implant. In an exemplary embodiment, the implant is implanted in a bone in a surgical procedure for securing a soft tissue to bone, such as a rotator cuff repair procedure or an anterior cruciate ligament (ACL) repair procedure. ## Claims ### Claim 1 A surgical device, comprising: a biocompatible tubular member configured to be implanted in a bone of a patient, the tubular member having a solid sidewall defining an inner lumen extending through the tubular member such that blood can flow into the inner lumen through a first open end of the inner lumen and out of the inner lumen through a second open end of the inner lumen, and the tubular member having an anti-coagulation agent on the solid sidewall; wherein the inner lumen has a bioabsorbable material disposed therein that occludes the inner lumen such that the blood cannot flow out of the inner lumen through the second open end of the inner lumen until the bioabsorbable material has been at least partially absorbed by the patient's body. ### Claim 2 A surgical device, comprising: a biocompatible tubular member configured to be implanted in a bone of a patient, the tubular member having a solid sidewall defining an inner lumen extending through the tubular member such that blood can flow into the inner lumen through a first open end of the inner lumen and out of the inner lumen through a second open end of the inner lumen, and the tubular member having an anti-coagulation agent on the solid sidewall; wherein the inner lumen has a plug removably disposed therein that occludes the inner lumen such that the blood cannot flow out of the inner lumen through the second open end of the inner lumen until the plug is removed from the inner lumen, the plug being configured to be implanted in the patient with the tubular member; and wherein the plug has a suture extending therefrom, the suture being configured to extend from inside the patient's body to outside the patient's body and to be pulled from outside the patient's body and thereby remove the plug from the inner lumen of the tubular member. ### Claim 3 A surgical device, comprising: a biocompatible tubular member configured to be implanted in a bone of a patient, the tubular member having a solid sidewall defining an inner lumen extending through the tubular member such that blood can flow into the inner lumen through a first open end of the inner lumen and out of the inner lumen through a second open end of the inner lumen, and the tubular member having an anti-coagulation agent on the solid sidewall; wherein the inner lumen has a plug removably disposed therein that occludes the inner lumen such that the blood cannot flow out of the inner lumen through the second open end of the inner lumen until the plug is removed from the inner lumen, the plug being configured to be implanted in the patient with the tubular member; and wherein the plug includes a knitted material that occludes the inner lumen until the knitted material is pulled to cause the knitted material to unravel. ### Claim 4 A surgical device, comprising: a biocompatible tubular member configured to be implanted in a bone of a patient, the tubular member having a solid sidewall defining an inner lumen extending through the tubular member such that blood can flow into the inner lumen through a first open end of the inner lumen and out of the inner lumen through a second open end of the inner lumen, and the tubular member having an anti-coagulation agent on the solid sidewall; wherein the inner lumen has a plug removably disposed therein that occludes the inner lumen such that the blood cannot flow out of the inner lumen through the second open end of the inner lumen until the plug is removed from the inner lumen, the plug being configured to be implanted in the patient with the tubular member; and wherein the plug is made from an energy activated material disposed therein that occludes the inner lumen until the energy activated material is activated by application of energy thereto. ### Claim 5 (depends on 1) The device of claim 1, wherein the tubular member includes a retaining member configured to engage the bone in which the tubular member is implanted to retain the tubular member within the bone. ### Claim 6 (depends on 1) The device of claim 1, wherein the anti-coagulation agent is coated on a surface of the solid sidewall. ### Claim 7 (depends on 1) The device of claim 1, wherein the anti-coagulation agent is impregnated in a material forming the solid sidewall. ### Claim 8 (depends on 1) The device of claim 1, wherein the anti-coagulation agent includes at least one of heparin, heparin sulfate, warfarin, hirudin, hirulog, coumarin, phosphorylcholine, indiandione, antithrombin III, bemiparin, dalteparin, danaparoid, enoxaparin, nadroparin, parnaparin, reviparin, sulodexide, tinzaparin, anticoagulant citrate dextrose solution A (ACD-A), ethylenediaminetetraacetic acid (EDTA), citrate, oxalate, a factor Xa inhibitor, and a thrombin inhibitor. ### Claim 9 (depends on 1) The device of claim 1, wherein the tubular member is bioabsorbable. ### Claim 10 (depends on 1) The device of claim 1, wherein the tubular member is not bioabsorbable. ### Claim 11 (depends on 1) The device of claim 1, wherein the bioabsorbable material has a suture extending therefrom, the suture being configured to extend from inside the patient's body to outside the patient's body and to be pulled from outside the patient's body. ### Claim 12 (depends on 4) The device of claim 4, wherein the tubular member includes a retaining member configured to engage the bone in which the tubular member is implanted to retain the tubular member within the bone. ### Claim 13 (depends on 4) The device of claim 4, wherein the anti-coagulation agent is at least one of coated on a surface of the solid sidewall and impregnated in a material forming the solid sidewall. ### Claim 14 (depends on 4) The device of claim 4, wherein the anti-coagulation agent includes at least one of heparin, heparin sulfate, warfarin, hirudin, hirulog, coumarin, phosphorylcholine, indiandione, antithrombin III, bemiparin, dalteparin, danaparoid, enoxaparin, nadroparin, parnaparin, reviparin, sulodexide, tinzaparin, anticoagulant citrate dextrose solution A (ACD-A), ethylenediaminetetraacetic acid (EDTA), citrate, oxalate, a factor Xa inhibitor, and a thrombin inhibitor. ### Claim 15 (depends on 2) The device of claim 2, wherein the tubular member includes a retaining member configured to engage the bone in which the tubular member is implanted to retain the tubular member within the bone. ### Claim 16 (depends on 2) The device of claim 2, wherein the anti-coagulation agent is at least one of coated on a surface of the solid sidewall and impregnated in a material forming the solid sidewall. ### Claim 17 (depends on 2) The device of claim 2, wherein the anti-coagulation agent includes at least one of heparin, heparin sulfate, warfarin, hirudin, hirulog, coumarin, phosphorylcholine, indiandione, antithrombin III, bemiparin, dalteparin, danaparoid, enoxaparin, nadroparin, parnaparin, reviparin, sulodexide, tinzaparin, anticoagulant citrate dextrose solution A (ACD-A), ethylenediaminetetraacetic acid (EDTA), citrate, oxalate, a factor Xa inhibitor, and a thrombin inhibitor. ### Claim 18 (depends on 3) The device of claim 3, wherein the tubular member includes a retaining member configured to engage the bone in which the tubular member is implanted to retain the tubular member within the bone. ### Claim 19 (depends on 3) The device of claim 3, wherein the anti-coagulation agent is at least one of coated on a surface of the solid sidewall and impregnated in a material forming the solid sidewall. ### Claim 20 (depends on 3) The device of claim 3, wherein the anti-coagulation agent includes at least one of heparin, heparin sulfate, warfarin, hirudin, hirulog, coumarin, phosphorylcholine, indiandione, antithrombin III, bemiparin, dalteparin, danaparoid, enoxaparin, nadroparin, parnaparin, reviparin, sulodexide, tinzaparin, anticoagulant citrate dextrose solution A (ACD-A), ethylenediaminetetraacetic acid (EDTA), citrate, oxalate, a factor Xa inhibitor, and a thrombin inhibitor.