# US 11,026,596 B1 · Detection and measurement of target substance in exhaled breath

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- Number: US 11,026,596 B1
- Document ID: US11026596B1
- Status: Granted
- Kind: B1
- Application number: 15/981,797
- Filed: 2018-05-16
- Granted: 2021-06-08
- Earliest claimed: 2017-05-19
- Assignees: Hound Labs, Inc.
- Applicants: Hound Labs, Inc.
- Inventors: Michael Scott Lynn; Hamilton Roger Tang; Kevin Bradford Dunk; Kevin M. Limtao; Hayuta Jain
- Web page: https://patentgrep.com/patent/US11026596B1

## CPC

- A61B 5/082: {Evaluation by breath analysis, e.g. determination of the chemical composition of exhaled breath (A61B5/083, A61B5/091 take precedence)}
- A61B 5/087: Measuring breath flow
- A61B 5/097: Devices for facilitating collection of breath or for directing breath into or through measuring devices
- G01N 33/497: of gaseous biological material, e.g. breath
- G01N 33/582: {with fluorescent label}
- G01N 33/948: {Sedatives, e.g. cannabinoids, barbiturates (opiates G01N33/9486)}
- A61B: DIAGNOSIS; SURGERY; IDENTIFICATION (usefulness limited to only animals A61D)
- G01N: INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES (measuring or testing apparatus or processes other than immunoassay, involving enzymes or microorganisms C12M, C12Q)

## Abstract

Systems, techniques and compositions can detect and measure a target substance, such as THC, in a constituent sample from exhaled human breath.

## Claims

### Claim 1

A method of detecting THC in exhaled breath, comprising:
receiving from a breath capture device an exhaled breath sample;
processing the breath sample such that THC in the breath sample forms a fluorescent-labeled THC sample adduct dissolved in a nonpolar phase of an adduct solution;
activating a fluorophore of the fluorescent-labeled THC sample adduct by adding a liquid phase chemical activator acryloyl species to the nonpolar phase; and
detecting by determining an amount of THC in the breath sample based on the measured fluorescence of the activated fluorophore of the fluorescent-labeled THC sample adduct in the nonpolar phase isolated from aqueous media.

### Claim 2 (depends on 1)

The method of claim 1, further comprising wherein the breath sample is also tested for ethanol, such that both THC and ethanol are measured from the same breath sample.

### Claim 3 (depends on 2)

The method of claim 2, wherein a portion of the breath sample is routed through a blood alcohol sensor for ethanol measurement.