Shoes with knit upper portion

A shoe, comprising:

• an upper portion defining a gap and comprising:
• an outer layer defining an exterior surface of the upper portion and;
• and
• an inner layer defining an interior surface of the upper portion, the outer layer and the inner layer extending along an entirety of the upper portion and defining:
• a first reinforcement region having a first thickness;
• a second reinforcement region adjacent to the gap and the first reinforcement region, the second reinforcement region having a first stiffness;
• and
• a flex region at least partially surrounded by the first reinforcement region and having a second thickness less than the first thickness and a second stiffness less than the first stiffness;
• and
• a tongue connected to the upper portion and configured to be positioned at least partially in the gap defined by the upper portion.

A shoe comprising:

• a sole;
• and
• a knit upper portion attached to the sole, the knit upper portion comprising:
• a first reinforcement region defining a gap and comprising:
• eucalyptus fiber;
• and
• a thermoplastic material bonded to the eucalyptus fiber;
• a second reinforcement region adjacent to the first reinforcement region and comprising:
• the eucalyptus fiber;
• and
• the thermoplastic material bonded to the eucalyptus fiber;
• and
• a flex region comprising the eucalyptus fiber and at least partially surrounded by the second reinforcement region;
• wherein:
• the knit upper portion comprises:
• a continuous outer layer defining a first surface of the knit upper portion in the first reinforcement region, the second reinforcement region, and the flex region;
• and
• a continuous inner layer defining a second surface of the knit upper portion opposite the first surface in the first reinforcement region, the second reinforcement region, and the flex region;
• and
• at least a part of the second reinforcement region is positioned between the first reinforcement region and a perimeter of the knit upper portion.