# US 11,026,444 B2 · Composition comprising human milk oligosaccharides (HMO) for use in the improvement of short term memory and other cognitive benefits > Agents: this data is available as JSON from the patentgrep API and MCP server — see https://patentgrep.com/llms.txt - Number: US 11,026,444 B2 - Document ID: US11026444B2 - Status: Granted - Kind: B2 - Application number: 16/615,605 - Filed: 2018-05-24 - Published: 2020-06-04 - Granted: 2021-06-08 - Earliest claimed: 2017-05-24 - Assignees: Societe des Produits Nestle S.A. - Applicants: Societe Des Produits Nestle S.A. - Inventors: Jian Yan; Jonas Hauser - Web page: https://patentgrep.com/patent/US11026444B2 ## CPC - A23L 33/21: Addition of substantially indigestible substances, e.g. dietary fibres - A23L 33/40: {Complete food formulations for specific consumer groups or specific purposes, e.g. infant formula} - A61K 31/702: Oligosaccharides, i.e. having three to five saccharide radicals attached to each other by glycosidic linkages - A61K 31/715: Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters - A23L: FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF (preservation thereof A23B) - A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D) ## Abstract The invention relates to a nutritional composition comprising a Human Milk Oligosaccharide (HMO) having an effect on the promoting, enhancement or improvement of the short term memory of the subjects in infants and/or young children. The composition can be an infant formula. The HMO may be 2FL, Di FL and/or LNT and or LNnT or combinations thereof. ## Claims ### Claim 1 A method to improve, enhance or promote declarative memory, short term memory and/or working memory in an infant or young mammal, the method comprising administering a nutritional composition comprising a combination of a human milk oligosaccharide (HMO) and a bovine milk oligosaccharide (BMO) to the infant or young mammal, wherein the HMO comprises 2′-fucosyllactose (2′FL) and lacto-N-neotetraose (LNnT); and the BMO comprises 3′-sialyllactose (3′-SL), 6′-sialyllactose (6′-SL) and a galacto-oligosaccharide (GOS). ### Claim 2 (depends on 1) The method according to claim 1, wherein the declarative memory is recognition memory. ### Claim 3 (depends on 1) The method according to claim 1, wherein the human milk oligosaccharide further comprises lacto-N-tetraose (LNT). ### Claim 4 (depends on 1) The method according to claim 1, wherein the HMO is present in an amount of from 0.1 to 10 g/L of the nutritional composition. ### Claim 5 (depends on 1) The method according to claim 1, wherein the nutritional composition further comprises a prebiotic, selected from the list consisting of inulin, xylooligosaccharides, polydextrose, fructose oligosaccharide (FOS), oligofructose (OF) and combinations thereof. ### Claim 6 (depends on 1) The method according to claim 1, wherein the bovine milk oligosaccharide further comprises at least one of an N-acetylated oligosaccharide, a fucosylated oligosaccharide or a combination thereof. ### Claim 7 (depends on 6) The method according to claim 6, wherein the N-acetylated oligosaccharide is selected from the group consisting of lacto-N-tetraose (LNT), lacto-N-neotetraose (LNnT) and a combination thereof. ### Claim 8 (depends on 6) The method according to claim 6, wherein the fucosylated oligosaccharide is selected from the group consisting of 2′-fucosyllactose (2′FL), 3-fucosyllactose, difucosyllactose (diFL), lacto-N-fucopentaoses, lacto-N-difucohexaose I, fucosyllacto-N-hexaose, difucosyllacto-N-hexaose I and difucosyllacto-N-neohexaose II. ### Claim 9 (depends on 1) The method according to claim 1, wherein the nutritional composition further comprises a probiotic. ### Claim 10 (depends on 1) The method according to claim 1, wherein the nutritional composition is selected from the group consisting of an infant formula, a follow on formula, a human milk fortifier and a growing up milk. ### Claim 11 (depends on 8) The method according to claim 8, wherein the fucosylated oligosaccharide is 2′-fucosyllactose (2-FL) and difucosyllactose (diFL). ### Claim 12 (depends on 5) The method according to claim 5, wherein the prebiotic comprises Oligofructose (OF) and inulin in a weight ratio of 7:3. ### Claim 13 (depends on 5) The method according to claim 5, wherein the prebiotic is an oligofructose (OF) in an amount of 0.1-20 g per 100 g of the nutritional composition on a dry weight basis. ### Claim 14 (depends on 13) The method according to claim 13, wherein a ratio between the GOS and the oligofructose (OF) in the nutritional composition is of 9:1. ### Claim 15 (depends on 1) The method according to claim 1, wherein a total amount of the 3′-SL and the 6′-SL is 0.05-2 g per 100 g of the nutritional composition on a dry weight basis. ### Claim 16 (depends on 1) The method according to claim 1, wherein a weight ratio between the 3′-SL and the 6′-SL is in a range between 5:1 and 1:2. ### Claim 17 (depends on 1) The method according to claim 1, wherein the LNnT is present in an amount of 0.1-3 g per 100 g of the nutritional composition on a dry weight basis. ### Claim 18 (depends on 1) The method according to claim 1, wherein the 2′FL is present in an amount of 0.1-3 g per 100 g of the nutritional composition on a dry weight basis. ### Claim 19 (depends on 1) The method according to claim 1, wherein the nutritional composition further comprises a protein source in an amount below 2.5 g/100 kcal of energy.