# US 11,026,441 B2 · Avocado flesh and/or skin extract rich in polyphenols and cosmetic, dermatological and nutraceutical compositions comprising same

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- Number: US 11,026,441 B2
- Document ID: US11026441B2
- Status: Granted
- Kind: B2
- Application number: 16/117,511
- Filed: 2018-08-30
- Published: 2018-12-27
- Granted: 2021-06-08
- Earliest claimed: 2010-12-22
- Assignees: Laboratoires Expanscience
- Applicants: Laboratoires Expanscience
- Inventors: Alex Saunois; Caroline Baudouin; Sophie Leclere-Bienfait; Sebastien Garnier; Philippe Msika
- Web page: https://patentgrep.com/patent/US11026441B2

## CPC

- A23L 19/07: {Fruit waste products, e.g. from citrus peel or seeds}
- A23L 19/09: {Mashed or comminuted products, e.g. pulp, purée, sauce, or products made therefrom, e.g. snacks (A23L19/01, A23L19/10, A23L27/63 and A23L21/00 take precedence)}
- A23L 33/105: Plant extracts, their artificial duplicates or their derivatives
- A61K 8/498: {having 6-membered rings or their condensed derivatives, e.g. coumarin}
- A61K 8/9789: Magnoliopsida [dicotyledons]
- A61K 8/9794: Liliopsida [monocotyledons]
- A61K 9/0014: {Skin, i.e. galenical aspects of topical compositions (non-active ingredients are additionally classified in A61K47/00; A61K9/0009, A61K9/0021, A61K9/7015, A61K9/7023 take precedence; cosmetic preparations A61K8/00, A61Q; preparations for wound dressings or bandages A61L26/00)}
- A61K 31/353: 3,4-Dihydrobenzopyrans, e.g. chroman, catechin
- A61K 36/54: Lauraceae (Laurel family), e.g. cinnamon or sassafras
- A61K 45/06: Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
- A61P 17/00: Drugs for dermatological disorders
- A61P 17/10: Anti-acne agents
- A61Q 5/12: Preparations containing hair conditioners
- A61Q 17/00: Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
- A61Q 17/04: Topical preparations for affording protection against sunlight or other radiation; Topical sun tanning preparations
- A61Q 19/00: Preparations for care of the skin
- A61Q 19/005: {Preparations for sensitive skin}
- A61Q 19/02: for chemically bleaching or whitening the skin
- A61Q 19/08: Anti-ageing preparations
- A23V 2002/00: Food compositions, function of food ingredients or processes for food or foodstuffs
- A61K 2800/92: Oral administration
- A23L: FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF (preservation thereof A23B)
- A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D)
- A61P: SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61Q: SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A23V: INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION

## Abstract

The invention relates to an avocado extract rich in polyphenols, containing at least 10% by weight of polyphenols, expressed in gallic acid equivalent relative to the dry extract obtained, wherein said polyphenols contain procyanidins, cafeic acid and cafeic acid derivatives, typically in a proportion of at least 70% by weight, expressed in gallic acid equivalent relative to the total polyphenol content by weight. The invention also relates to a composition comprising an extract according to the invention as active agent and a suitable excipient. The invention also relates to such a composition or such an extract for use thereof in preventing or treating disorders or pathological conditions of the skin, the mucous membranes or the superficial body growths. Finally, the invention relates to a cosmetic care process for the skin, the superficial body growths or the mucous membranes, with a view to improving the condition thereof or the appearance thereof, which consists in administering such a composition or such an extract.

## Claims

### Claim 1

A method for preventing and/or treating allergic, inflammatory or irritative reactions of the skin and/or mucous membranes and/or appendages, or for preventing and/or treating disorders or pathologies of the skin barrier, or homeostasis of the skin, comprising administering to a subject in need thereof an effective amount of a cosmetic, pharmaceutical, dermatological, or nutraceutical composition comprising
a polyphenol-rich extract of avocado fruit, comprising at least 10% polyphenols by weight, expressed in gallic acid equivalents in relation to the dry extract, and comprising 0 to 10% by weight of avocado lipids in relation to the dry extract, wherein the polyphenols comprise a mixture of procyanidins, caffeic acid and derivatives of caffeic acid, wherein the mixture is at least 70% by weight, expressed in gallic acid equivalents, in relation to total polyphenol content by weight, and wherein the mixture contains at least 20% caffeic acid and derivatives of caffeic acid and at least 30% procyanidins by weight, expressed in gallic acid equivalents, in relation to total polyphenol content by weight,
wherein the extract further comprises at least 10% avocado sugars by weight in relation to the weight of the dry extract, said sugars containing at least D-mannoheptulose and/or perseitol, and
wherein the extract further comprises 1 to 30% avocado proteins by weight in relation to the weight of the dry extract, and
a suitable carrier.

### Claim 2

A method for preventing and/or treating allergic, inflammatory or irritative reactions of the skin and/or mucous membranes and/or appendages, or for preventing and/or treating disorders or pathologies of the skin barrier, or homeostasis of the skin, comprising administering to a subject in need thereof an effective amount of a polyphenol-rich extract of avocado fruit, comprising at least 10% polyphenols by weight, expressed in gallic acid equivalents in relation to the dry extract, and comprising 0 to 10% by weight of avocado lipids in relation to the dry extract, wherein the polyphenols comprise a mixture of procyanidins, caffeic acid and derivatives of caffeic acid, wherein the mixture is at least 70% by weight, expressed in gallic acid equivalents, in relation to total polyphenol content by weight, and wherein the mixture contains at least 20% caffeic acid and derivatives of caffeic acid and at least 30% procyanidins by weight, expressed in gallic acid equivalents, in relation to total polyphenol content by weight,
wherein said extract further comprises at least 10% avocado sugars by weight in relation to the weight of the dry extract, said sugars containing at least D-mannoheptulose and/or perseitol, and
wherein said extract further comprises 1 to 30% avocado proteins by weight in relation to the weight of the dry extract.

### Claim 3

A method for healing or depigmenting the skin and/or mucous membranes and/or appendages, comprising administering to a subject in need thereof an effective amount of a cosmetic, pharmaceutical, dermatological, or nutraceutical composition comprising
a polyphenol-rich extract of avocado fruit, comprising at least 10% polyphenols by weight, expressed in gallic acid equivalents in relation to the dry extract, and comprising 0 to 10% by weight of avocado lipids in relation to the dry extract, wherein the polyphenols comprise a mixture of procyanidins, caffeic acid and derivatives of caffeic acid, wherein the mixture is at least 70% by weight, expressed in gallic acid equivalents, in relation to total polyphenol content by weight, and wherein the mixture contains at least 20% caffeic acid and derivatives of caffeic acid and at least 30% procyanidins by weight, expressed in gallic acid equivalents, in relation to total polyphenol content by weight,
wherein said extract further comprises at least 10% avocado sugars by weight in relation to the weight of the dry extract, said sugars containing at least D-mannoheptulose and/or perseitol, and
wherein said extract further comprises 1 to 30% avocado proteins by weight in relation to the weight of the dry extract, and
a suitable carrier.

### Claim 4

A method for healing or depigmenting the skin and/or mucous membranes and/or appendages, comprising administering to a subject in need thereof an effective amount of a polyphenol-rich extract of avocado fruit, comprising at least 10% polyphenols by weight, expressed in gallic acid equivalents in relation to the dry extract, and comprising 0 to 10% by weight of avocado lipids in relation to the dry extract, wherein the polyphenols comprise a mixture of procyanidins, caffeic acid and derivatives of caffeic acid, wherein the mixture is at least 70% by weight, expressed in gallic acid equivalents, in relation to total polyphenol content by weight, wherein the mixture contains at least 20% caffeic acid and derivatives of caffeic acid and at least 30% procyanidins by weight, expressed in gallic acid equivalents, in relation to total polyphenol content by weight, and
wherein said extract further comprises at least 10% avocado sugars by weight in relation to the weight of the dry extract, said sugars containing at least D-mannoheptulose and/or perseitol, and
wherein said extract further comprises 1 to 30% avocado proteins by weight in relation to the weight of the dry extract.

### Claim 5

A method for preventing and/or treating vascular disorders, comprising administering to a subject in need thereof an effective amount of a cosmetic, pharmaceutical, dermatological, or nutraceutical composition comprising
a polyphenol-rich extract of avocado fruit, comprising at least 10% polyphenols by weight, expressed in gallic acid equivalents in relation to the dry extract, and comprising 0 to 10% by weight of avocado lipids in relation to the dry extract, wherein the polyphenols comprise a mixture of procyanidins, caffeic acid and derivatives of caffeic acid, wherein the mixture is at least 70% by weight, expressed in gallic acid equivalents, in relation to total polyphenol content by weight, and wherein the mixture contains at least 20% caffeic acid and derivatives of caffeic acid and at least 30% procyanidins by weight, expressed in gallic acid equivalents, in relation to total polyphenol content by weight, and
wherein said extract further comprises at least 10% avocado sugars by weight in relation to the weight of the dry extract, said sugars containing at least D-mannoheptulose and/or perseitol, and
wherein said extract further comprises 1 to 30% avocado proteins by weight in relation to the weight of the dry extract, and
a suitable carrier.

### Claim 6

A method for preventing and/or treating vascular disorders, comprising administering to a subject in need thereof an effective amount of a polyphenol-rich extract of avocado fruit, comprising at least 10% polyphenols by weight, expressed in gallic acid equivalents in relation to the dry extract, and comprising 0 to 10% by weight of avocado lipids in relation to the dry extract, wherein the polyphenols comprise a mixture of procyanidins, caffeic acid and derivatives of caffeic acid, wherein the mixture is at least 70% by weight, expressed in gallic acid equivalents, in relation to total polyphenol content by weight, and wherein the mixture contains at least 20% caffeic acid and derivatives of caffeic acid and at least 30% procyanidins by weight, expressed in gallic acid equivalents, in relation to total polyphenol content by weight, and
wherein said extract further comprises at least 10% avocado sugars by weight in relation to the weight of the dry extract, said sugars containing at least D-mannoheptulose and/or perseitol, and
wherein said extract further comprises 1 to 30% avocado proteins by weight in relation to the weight of the dry extract.

### Claim 7

A cosmetic care method for the skin and/or appendages and/or mucous membranes, for improving the condition and/or appearance of sensitive skin, or for preventing the accumulation of adipose tissue or skin with cellulitis, comprising administering to a subject in need thereof an effective amount of a cosmetic composition comprising
a polyphenol-rich extract of avocado fruit, comprising at least 10% polyphenols by weight, expressed in gallic acid equivalents in relation to the dry extract, and comprising 0 to 10% by weight of avocado lipids in relation to the dry extract, wherein the polyphenols comprise a mixture of procyanidins, caffeic acid and derivatives of caffeic acid, wherein the mixture is at least 70% by weight, expressed in gallic acid equivalents, in relation to total polyphenol content by weight, and wherein the mixture contains at least 20% caffeic acid and derivatives of caffeic acid and at least 30% procyanidins by weight, expressed in gallic acid equivalents, in relation to total polyphenol content by weight, and
wherein said extract further comprises at least 10% avocado sugars by weight in relation to the weight of the dry extract, said sugars containing at least D-mannoheptulose and/or perseitol, and
wherein said extract further comprises 1 to 30% avocado proteins by weight in relation to the weight of the dry extract, and
a suitable carrier.

### Claim 8

A cosmetic care method for the skin and/or appendages and/or mucous membranes, for improving the condition and/or appearance of sensitive skin, or for preventing the accumulation of adipose tissue or skin with cellulitis, comprising administering to a subject in need thereof an effective amount of a polyphenol-rich extract of avocado fruit, comprising at least 10% polyphenols by weight, expressed in gallic acid equivalents in relation to the dry extract, and comprising 0 to 10% by weight of avocado lipids in relation to the dry extract, wherein the polyphenols comprise a mixture of procyanidins, caffeic acid and derivatives of caffeic acid, wherein the mixture is at least 70% by weight, expressed in gallic acid equivalents, in relation to total polyphenol content by weight, and wherein the mixture contains at least 20% caffeic acid and derivatives of caffeic acid and at least 30% procyanidins by weight, expressed in gallic acid equivalents, in relation to total polyphenol content by weight, and
wherein said extract further comprises at least 10% avocado sugars by weight in relation to the weight of the dry extract, said sugars containing at least D-mannoheptulose and/or perseitol, and
wherein said extract further comprises 1 to 30% avocado proteins by weight in relation to the weight of the dry extract.

### Claim 9

A cosmetic care method for the skin and/or appendages and/or mucous membranes, for reducing pigmentation spots, comprising administering to a subject in need thereof an effective amount of a cosmetic composition comprising
a polyphenol-rich extract of avocado fruit, comprising at least 10% polyphenols by weight, expressed in gallic acid equivalents in relation to the dry extract, and comprising 0 to 10% by weight of avocado lipids in relation to the dry extract, wherein the polyphenols comprise a mixture of procyanidins, caffeic acid and derivatives of caffeic acid, wherein the mixture is at least 70% by weight, expressed in gallic acid equivalents, in relation to total polyphenol content by weight, and wherein the mixture contains at least 20% caffeic acid and derivatives of caffeic acid and at least 30% procyanidins by weight, expressed in gallic acid equivalents, in relation to total polyphenol content by weight, and
wherein said extract further comprises at least 10% avocado sugars by weight in relation to the weight of the dry extract, said sugars containing at least D-mannoheptulose and/or perseitol, and
wherein said extract further comprises 1 to 30% avocado proteins by weight in relation to the weight of the dry extract, and
a suitable carrier.

### Claim 10

A cosmetic care method for the skin and/or appendages and/or mucous membranes, for reducing pigmentation spots, comprising administering to a subject in need thereof an effective amount of a polyphenol-rich extract of avocado fruit, comprising at least 10% polyphenols by weight, expressed in gallic acid equivalents in relation to the dry extract, and comprising 0 to 10% by weight of avocado lipids in relation to the dry extract, wherein the polyphenols comprise a mixture of procyanidins, caffeic acid and derivatives of caffeic acid, wherein the mixture is at least 70% by weight, expressed in gallic acid equivalents, in relation to total polyphenol content by weight, and wherein the mixture contains at least 20% caffeic acid and derivatives of caffeic acid and at least 30% procyanidins by weight, expressed in gallic acid equivalents, in relation to total polyphenol content by weight, and
wherein said extract further comprises at least 10% avocado sugars by weight in relation to the weight of the dry extract, said sugars containing at least D-mannoheptulose and/or perseitol, and
wherein said extract further comprises 1 to 30% avocado proteins by weight in relation to the weight of the dry extract.

### Claim 11

A cosmetic care method for preventing and/or treating ageing of the skin and/or the appendages and/or the mucous membranes, comprising administering to a subject in need thereof an effective amount of a cosmetic composition comprising
a polyphenol-rich extract of avocado fruit, comprising at least 10% polyphenols by weight, expressed in gallic acid equivalents in relation to the dry extract, and comprising 0 to 10% by weight of avocado lipids in relation to the dry extract, wherein the polyphenols comprise a mixture of procyanidins, caffeic acid and derivatives of caffeic acid, wherein the mixture is at least 70% by weight, expressed in gallic acid equivalents, in relation to total polyphenol content by weight, and wherein the mixture contains at least 20% caffeic acid and derivatives of caffeic acid and at least 30% procyanidins by weight, expressed in gallic acid equivalents, in relation to total polyphenol content by weight, and
wherein said extract further comprises at least 10% avocado sugars by weight in relation to the weight of the dry extract, said sugars containing at least D-mannoheptulose and/or perseitol, and
wherein said extract further comprises 1 to 30% avocado proteins by weight in relation to the weight of the dry extract, and
a suitable carrier.

### Claim 12

A cosmetic care method for preventing and/or treating ageing of the skin and/or the appendages and/or the mucous membranes, comprising administering to a subject in need thereof an effective amount of a polyphenol-rich extract of avocado fruit, comprising at least 10% polyphenols by weight, expressed in gallic acid equivalents in relation to the dry extract, and comprising 0 to 10% by weight of avocado lipids in relation to the dry extract, wherein the polyphenols comprise a mixture of procyanidins, caffeic acid and derivatives of caffeic acid, wherein the mixture is at least 70% by weight, expressed in gallic acid equivalents, in relation to total polyphenol content by weight, and wherein the mixture contains at least 20% caffeic acid and derivatives of caffeic acid and at least 30% procyanidins by weight, expressed in gallic acid equivalents, in relation to total polyphenol content by weight, and
wherein said extract further comprises at least 10% avocado sugars by weight in relation to the weight of the dry extract, said sugars containing at least D-mannoheptulose and/or perseitol, and
wherein said extract further comprises 1 to 30% avocado proteins by weight in relation to the weight of the dry extract.