Mutant genes related to drug resistance and relapse of acute lymphoblastic leukaemia and a use thereof

A recombinant protein comprising a PRPS1 mutant fused to a heterologous His tag, wherein the PRPS1 mutant is formed by making amino acid substitution at any one or more of the following positions of SEQ ID NO:

• 2:
• serine is substituted by threonine at position 103, serine is substituted by asparagine at position 103, asparagine is substituted by serine at position 144, lysine is substituted by asparagine at position 176, aspartic acid is substituted by glutamic acid at position 183, alanine is substituted by threonine at position 190, leucine is substituted by phenylalanine at position 191, threonine is substituted by serine at position 303, valine is substituted by alanine at position 53, isoleucine is substituted by valine at position 72, cysteine is substituted by serine at position 77, aspartic acid is substituted by glycine at position 139, tyrosine is substituted by cysteine at position 311, serine is substituted by isoleucine at position 103, asparagine is substituted by aspartic acid at position 114 or glycine is substituted by glutamic acid at position 174.