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US 11,021,683 B2Granted
Tangential flow depth filtration systems and methods of filtration using same
AssigneeRepligen Corporation
InventorsMichael Bransby, Derek Carroll
Life of this patent
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Abstract
The present disclosure relates to hollow fiber tangential flow filters, including hollow fiber tangential flow depth filters, for various applications, including bioprocessing and pharmaceutical applications, systems employing such filters, and methods of filtration using the same.
Claims29
A bioprocessing system comprising:
- a process vessel;
- a tangential flow depth filtration (TFDF) unit comprising a thick-walled hollow fiber comprising a porous wall defining a lumen that is in fluid communication with the process vessel;
- a permeate fluid outlet in fluid communication with the porous wall;
- and
- wherein a density of the hollow fiber is between about 51% and about 56% of the density of an equivalent solid volume of the hollow fiber.
2 more elements
A tangential flow depth filtration (TFDF) unit comprising:
- a hollow fiber comprising a porous wall having a density between about 51% and about 56% of the density of an equivalent solid volume of the hollow fiber, the porous wall defining a lumen;
- an inlet in fluid communication with the lumen;
- and
- a permeate fluid outlet in fluid communication with the porous wall.
1 more element
A method of filtering a fluid, the method comprising:
- flowing a fluid from a process vessel into a tangential flow depth filter (TFDF) unit comprising a thick-walled hollow fiber comprising a porous wall having a pore size and a density between about 51% and about 56% of the density of an equivalent solid volume of the hollow fiber, the porous wall defining a lumen that is in fluid communication with the process vessel, the TFDF unit having a permeate fluid outlet in fluid communication with the porous wall.
Dependencies are inferred from the claim text.