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US 11,021,496 B2Granted
Mesoporous organosilica nanoparticles, production method thereof and uses of same
AssigneesCentre National De La Recherche Scientifique, Universite De Montpellier, Nanomedsyn
InventorsJean Olivier Durand, Jimenez Chiara Mauriello, Sebastien Richeter, Laurence Raehm, Magali Gary-Bobo, Marcel Garcia, Marie Maynadier
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Abstract
The present invention relates to mesoporous organosilica nanoparticles, the method of preparation thereof, and uses of the same in treatment by means of photodynamic therapy or in imaging.
Claims17
Mesoporous organosilica nanoparticles comprising:
- (i) a porphyrin derivative being a compound having the formula A
- in which:
- either R1, R2, R3, and R4 all correspond to
- where X is an oxygen atom or a sulfur atom;
- or R1, R2, R3, and R4 all correspond to
- (ii) a compound having the formula I:
- (EtO)3Si(CH2)nSi(OEt)3,
- in which n represents an integer selected from 1 to 10,
- wherein the porphyrin derivative aggregates into a J aggregate and wherein the nanoparticles optionally encapsulate at least one hydrophilic and/or hydrophobic anticancer compound.
6 more elements
Dependencies are inferred from the claim text.