PSMA targeted fluorescent agents for image guided surgery

A compound having the structure:

• wherein:
• Z is tetrazole or CO2Q;
• each Q is independently selected from hydrogen or a protecting group;
• FG is a fluorescent dye moiety which emits in the visible or near infrared spectrum;
• each R is independently H or C1-C4 alkyl;
• V is —C(O)—;
• W is —NRC(O);
• Y is —C(O);
• a is 1, 2, 3, or 4;
• m is 1, 2, 3, 4, 5, or 6;
• n is 1, 2, 3, 4, 5 or 6;
• p is 0, 1, 2, or 3, and when p is 2 or 3, each R1 may be the same or different;
• R1 is H, C1-C6 alkyl, C6-C12 aryl, or alkylaryl having 1 to 3 separate or fused rings and from 6 to about 18 ring carbon atoms;
• R2 and R3 are independently H, CO2H, or CO2R4, where R4 is a C1-C6 alkyl, C6-C12 aryl, or alkylaryl having 1 to 3 separate or fused rings and from 6 to about 18 ring carbon atoms, wherein when one of R2 and R3 is CO2H or CO2R4, the other is H.