Microfluidic extrusion
AssigneeEmbody, Inc.
InventorsMichael P. Francis, Stella Petrova, Nicholas Thayer
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Abstract
A biopolymer fiber containing collagen. The biopolymer fiber has excellent ultimate tensile strength, modulus of elasticity, and strain at break comparable to native human tendons and ligaments. The fiber may substantially circular, ovoid, square, rectangular, ribbon-like, triangular, or irregularly shaped. The fiber exhibits an ordered, longitudinally-oriented structure, and the fiber allows infiltration of cellular growth. Implantable biopolymer scaffolds and sutures containing the fibers are provided as well as microfluidic and extrusion methods for producing the biopolymer fibers.
Claims30
An extruded collagen fiber comprising:
- a plurality of extruded sub-fibers;
- wherein the sub-fibers are cross-linked with glyoxal.
A plurality of extruded collagen fibers, the fibers being associated in the form factor of a bundle;
- wherein sub-fibers of the fibers are cross-linked with glyoxal;
- wherein the fibers exhibit an ordered, longitudinally oriented structure;
- and
- wherein the extruded collagen fiber has one or more of the following characteristics:
- ultimate tensile strength is between about 1 MPa to about 800 MPa;
- the modulus of elasticity is between about 10 MPa to about 7,500 MPa;
- and
- the average fiber diameter is between about 10 μm and about 30 μm.
Dependencies are inferred from the claim text.