Biaryloxy derivatives as TTX-S blockers

A compound of the following formula (I):

• wherein:
• A is aryl or heteroaryl;
• W is selected from the group consisting of a chemical bond, —NRa—, —O—, and —S—;
• Ra is hydrogen or C1-6 alkyl;
• R1 is independently selected from the group consisting of:
• (1) C3-7 cycloalkyl, (2) heterocyclyl, (3) C3-7 cycloalkylC1-6 alkyl, and (4) heterocyclylC1-6 alkyl;
• wherein the C3-7 cycloalkyl, the heterocyclyl, the C3-7 cycloalkylC1-6 alkyl, or the heterocyclylC1-6 alkyl is unsubstituted or substituted with one or more substituents independently selected from the group consisting of:
• halogen, hydroxyl,C1-6 alkyl, —O—C1-6 alkyl, hydroxylC1-6 alkyl, hydroxylC1-6 alkoxy, —NR6R7, —(C═O)—R6, —(C═O)—OR6, —(C═O)—NR6R7, and —NR6—(C═O)—R7;
• R2 is independently selected from the group consisting of:
• (1) hydrogen, (2) halogen, (3) hydroxyl, (4) C1-6 alkyl, (5) —O—C1-6 alkyl, (6) C3-7 cycloalkyl-, (7) —O—C3-7 cycloalkyl, (8) —(C═O)—NR6R7, (9) —NR6(C═O)R7, (10) —NR6(C═O)NR7R8, (11) —NR6R7, (12) —CN, and (13) —NO2;
• wherein the C1-6 alkyl, the —O—C1-6 alkyl, the C3-7 cycloalkyl, or the —O—C3-7 cycloalkyl is unsubstituted or substituted with one or more substituents independently selected from the group consisting of:
• halogen, hydroxyl, C1-6 alkoxyl, —NR6R7, —(C═O)—NR6R7, —NR6—(C═O)—R7, and —NR6CH2—(C═O)—NH2;
• p is 0, 1, 2, 3, or 4;
• when p is two or more, each R2 is the same or different;
• R3 is independently selected from the group consisting of:
• (1) hydrogen, (2) halogen, (3) hydroxyl, (4) C1-6 alkyl, (5) —O—C1-6 alkyl, wherein the C1-6alkyl or the —O—C1-6 alkyl is unsubstituted or substituted with one or more substituents independently selected form the group consisting of:
• halogen, hydroxyl, C1-6 alkoxyl, and C3-7 cycloalkyl, (6) C3-7 cycloalkyl, (7) —O—C3-7 cycloalkyl, (8) aryl, (9) heteroaryl, (10) heterocyclyl, (11) —NR6R7, and (12) —CN;
• wherein the C3-7 cycloalkyl, the —O—C3-7 cycloalkyl, the aryl, the heteroaryl, or the heterocyclyl is unsubstituted or substituted with one or more substituents independently selected form the group consisting of:
• halogen, hydroxyl, and C1-6 alkyl;
• q is 0, 1, 2, 3, or 4;
• when q is two or more, each R3 is the same or different;
• X is CR3 or N;
• Y is CR3 or N;
• R4 is independently selected from the group consisting of:
• (1) hydrogen, (2) halogen, (3) hydroxyl, (4) C1-6 alkyl, (5) —O—C1-6 alkyl, (6) C3-7 cycloalkyl, (7) —O—C3-7 cycloalkyl, and (8) —CN;
• wherein the C1-6 alkyl, the —O—C1-6 alkyl, the C3-7 cycloalkyl, or the —O—C3-7 cycloalkyl is unsubstituted or substituted with one or more substituents independently selected form the group consisting of:
• halogen and hydroxyl;
• r is 0, 1, 2, 3, or 4;
• when r is two or more, each R4 is the same or different;
• Z is CR4 or N;
• R5 is selected from the group consisting of:
• (1) C1-6 alkyl, (2) —O—C1-6 alkyl, (3) C3-7 cycloalkyl, (4) C3-7 cycloalkylC1-6 alkyl, wherein the C1-6 alkyl, the —O—C1-6 alkyl, the C3-7 cycloalkyl, or the C3-7 cycloalkylC1-6 alkyl is unsubstituted or substituted with one or more substituents independently selected form the group consisting of:
• halogen, hydroxyl, and C1-6 alkoxyl, (5) aryl, (6) heteroaryl, wherein the aryl or the heteroaryl is unsubstituted or substituted with one or more substituents independently selected form the group consisting of:
• halogen, hydroxyl, C1-6 alkyl and C1-6 alkoxyl, and (7) —NR6R7;
• R6 and R7 are independently selected from the group consisting of:
• (1) hydrogen, (2) C1-6 alkyl, and (3) C1-6 alkoxyC1-6 alkyl, wherein the C1-6 alkyl or the C1-6 alkoxyC1-6 alkyl is unsubstituted or substituted with one or more substituents independently selected from the group consisting of:
• halogen and hydroxyl;
• R6 may form a 4 to 7 membered ring with R7 which may contain a nitrogen atom, an oxygen atom, a sulfur atom, carbonyl, or a double bond;
• wherein the 4 to 7 membered ring is unsubstituted or substituted with one or more substituents independently selected from the group consisting of:
• halogen, hydroxyl, and C1-6 alkoxyl;
• or a pharmaceutically acceptable salt thereof.