Flexible application of cross-calibration for quantitative functional imaging

A non-transitory computer readable storage medium having stored therein data representing instructions executable by a programmed processor for application of cross-calibration in a single photon emission computed tomography (SPECT) system, the storage medium comprising instructions for:

• receiving input of identity of first and second radioactive sources;
• searching for characteristics of the first and second radioactive sources from a standardized list of sources and from a custom list of un-standardized sources;
• determining system-specific sensitivity for the SPECT system and a cross-calibration factor of radioactive sources, the determining based on the characteristics;
• and
• generating a quantitative SPECT image as a function of the system-specific sensitivity and the cross-calibration factor.

A system for application of cross-calibration in functional imaging quantification, the system comprising:

• a functional imaging system with a detector;
• a well counter;
• a first isotope source;
• a second isotope source;
• a processor configured to determine a sensitivity for the detector, the sensitivity responsive to a measure by the well counter, and to determine a cross-calibration between the first and second isotope sources as a function of the sensitivity, the cross-calibration being specific to the well counter, wherein the processor is further configured to search a table of cross-calibrations including the cross-calibration based on a selection of the well counter and to correct a patient dose measured by the well counter, the correction being a function of the cross-calibration;
• and
• a memory configured to store the sensitivity and the cross-calibration in tables linked to the well counter.

A system for application of cross-calibration in functional imaging quantification, the system comprising:

• a functional imaging system with a detector;
• a well counter;
• a first isotope source, wherein the first isotope source has a plurality of energy windows;
• a second isotope source;
• a processor configured to determine a sensitivity for the detector, the sensitivity responsive to a measure by the well counter, and to determine a cross-calibration between the first and second isotope sources as a function of the sensitivity, the cross-calibration being specific to the well counter;
• a memory configured to store the sensitivity and the cross-calibration in tables linked to the well counter;
• and
• a user interface configured for selection of a first of the energy windows for a photo-peak window and selection of a second of the energy windows for a scatter window, and wherein the sensitivity and cross-calibration are determined specific to the photo-peak and scatter windows.