Method for diagnosing or monitoring kidney function or diagnosing kidney dysfunction
AssigneeSphingotec GmbH
InventorAndreas Bergmann
Life of this patent
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Abstract
A method for (a) diagnosing or monitoring kidney function in subject or (b) diagnosing kidney dysfunction in a subject or (c) predicting or monitoring the risk of an adverse events in a diseased subject or (d) predicting or monitoring the success of a therapy or intervention comprising determining the level of Pro-Enkephalin (PENK) or fragments thereof of at least 5 amino acids in a bodily fluid obtained from said subject; and correlating said level of Pro-Enkephalin or fragments thereof with (a) kidney function in a subject or (b) kidney dysfunction in said subject or (c) enhanced risk of adverse events or (d) success of a therapy or intervention in a diseased subject.
Claims11
A method for diagnosing or monitoring kidney function in a subject comprising:
- determining the level of Pro-Enkephalin or fragments thereof of at least 5 amino acids in a bodily fluid obtained from said subject;
- and
- monitoring kidney function in a subject with a follow-up measurement of the level of Pro-Enkephalin or fragments thereof of at least 5 amino acids in a bodily fluid obtained from said subject,
- wherein during said follow-up measurement, a relative change of Pro-Enkephalin or fragments thereof of at least 5 amino acids that is lowered, correlates with the improvement of the subject's kidney function, or
- wherein during said follow-up measurement, a relative change of Pro-Enkephalin or fragment thereof of at least 5 amino acids that is increased, correlates with the worsening of the subject's kidney function, and
- wherein said determination of Pro-Enkephalin or fragments thereof of at least 5 amino acids is performed more than once in one subject, and
- wherein said Pro-Enkephalin or fragment thereof is SEQ ID No. 1, or SEQ ID No. 6 and
- wherein an assay is used comprising two binders that bind to two different regions within the region of Pro-Enkephalin that is amino acid 133-140 (LKELLETG, SEQ ID NO. 13) and amino acid 152-159 (SDNEEEVS, SEQ ID No. 14) wherein each of said regions comprises at least 4 or 5 amino acids.
A method for diagnosing or monitoring kidney function in a subject comprising:
- determining the level of Pro-Enkephalin or fragments thereof of at least 5 amino acids in a bodily fluid obtained from said subject;
- and
- monitoring kidney function in a subject with a follow-up measurement of the level of Pro-Enkephalin or fragments thereof of at least 5 amino acids in a bodily fluid obtained from said subject,
- wherein during said follow-up measurement, a relative change of Pro-Enkephalin or fragments thereof of at least 5 amino acids that is lowered correlates with the improvement of the subject's kidney function, or
- wherein during said follow-up measurement, a relative change of Pro-Enkephalin or fragments thereof of at least 5 amino acids that is increased correlates with the worsening of the subject's kidney function, and
- wherein said determination of Pro-Enkephalin or fragments thereof of at least 5 amino acids is performed more than once in one subject, and
- wherein said Pro-Enkephalin or fragment thereof is SEQ ID No. 1, or SEQ ID No. 6
- and
- wherein additionally at least one clinical parameter is determined that is age, BUN, NGAL, Creatinine Clearance, Creatinine or Apache Score
- and
- wherein an assay is used comprising two binders that bind to two different regions within the region of Pro-Enkephalin that is amino acid 133-140 (LKELLETG, SEQ ID NO. 13) and amino acid 152-159 (SDNEEEVS, SEQ ID No. 14) wherein each of said regions comprises at least 4 or 5 amino acids.
Dependencies are inferred from the claim text.