Back to results
US 11,014,935 B2Granted
Compounds for the treatment of paramyxovirus viral infections
AssigneeJanssen BioPharma, Inc.
InventorsGuangyi Wang, Leonid Beigelman, Anh Truong, Carmela Napolitano, Daniele Andreotti, Haiying He
Life of this patent
Estimating the term…
Abstract
Disclosed herein are new antiviral compounds, together with pharmaceutical compositions that include one or more antiviral compounds, and methods of synthesizing the same. Also disclosed herein are methods of ameliorating and/or treating a paramyxovirus viral infection with one or more small molecule compounds. Examples of paramyxovirus infection include an infection caused by human respiratory syncytial virus (RSV).
Claims8
A compound of Formula (II), or a pharmaceutically acceptable salt thereof, having the structure:
- Ab-Lb-Yb (II)
- wherein:
- Lb is
- Ab is phenyl, wherein the phenyl is unsubstituted or substituted with one or more groups selected from the group consisting of:
- (a) hydroxy,
- (b) halogen,
- (c) nitro,
- (d) alkyl optionally substituted with one or more substituents selected from the group consisting of halogen, hydroxy, and —O(C1-6 alkyl),
- (e) amino optionally substituted with one or two alkyl groups,
- (f) —O-(alkyl) optionally substituted with one or more substituents selected from the group consisting of hydroxy, halogen, alkoxy, cyano, amino optionally substituted with one or two alkyl groups, cycloalkyl, C-carboxy, and C-amido, and
- (g) —O-(cycloalkyl) optionally substituted with one or more substituents selected from the group consisting of hydroxy, halogen, alkyl, alkoxy, and amino optionally substituted with one or two alkyl groups;
- Yb is benzothiophenyl optionally substituted with one or more groups selected from the group consisting of halogen, alkyl optionally substituted with one or more halogen groups, hydroxy, alkenyl, alkynyl, alkoxy optionally substituted with one or more halogen groups, haloalkoxy, cyano, C-carboxy, —C-amido, sulfonyl, and aryl;
- R1b is hydrogen or an unsubstituted C1-4 alkyl;
- R2b and R2b1 are each independently hydrogen or C1-4 alkyl optionally substituted with one or more groups selected from the group consisting of hydroxy, alkoxy, amino, and C-carboxy, and when more than one R2b and/or more than one R2b1 are present, each R2b and each R2b1 is the same or different;
- and
- ring B1 is pyridinyl optionally substituted with one or more substituents selected from the group consisting of hydrogen, halogen, hydroxy, alkenyl, alkynyl, cycloalkyl, aryl, alkoxy optionally substituted with one or more halogen groups, amino optionally substituted with one or more alkyl groups, C-carboxy, and alkyl optionally substituted with one or more groups selected from hydroxy, alkoxy, halo, and cycloalkyl.
13 more elements
Dependencies are inferred from the claim text.