Reduction-triggered antibacterial sideromycins

A compound, comprising:

• an Fe(III)-binding siderophore, or an Fe(III)-bound siderophore;
• one or more optional linkers covalently bound to the siderophore;
• a drug;
• and
• an Fe(III) to Fe(II) reduction triggered linker having the following formula Q bound to the drug and the linker or, if no linker is present, then bound to the drug and the siderophore:
• wherein J is a covalent bond or group having the formula —(CO)NR′— or —NR′—, J being bound to the linker or, if no linker is present, then to the siderophore;
• wherein K is a covalent bond, —O—, or —NR′—, K being bound to the drug;
• and
• R′ is independently H or alkyl;
• or pharmaceutically acceptable salt or solvate thereof;
• wherein the drug is an antibiotic selected from the group consisting of amikacin, aminoglycoside, amoxicillin, amphotericin, ampicillin, ansamycin, azithromycin, aztreonam, bacillomycin, BAL30072, beta-lactam, biapenem, carbacephalosporins, carbapenem, carbomycin, carbomycin A, carumonam, cefaclor, cefalotin, cephalosporin, cethromycin, chloramphenicol, chlortetracycline, clarithromycin, clindamycin, daptomycin, demeclocycline, dirithromycin, doripenem, doxorubicin, doxycycline, ertapeneme, erythromycin, ethambutol, fluoroquinolone, gentamicin, imipenem, isoniazid, josamycin, kanamycin, kitasamycin, lincomycin, linezolid, loracarbef, macrolide, meropenem, methacycline, midecamycin, monobactam, mupirocin, neomycin, nystatin, oleandomycin, oleandomycin, oxazolidinones, oxytetracycline, panipenem, penem, penicillin, peptide antibiotic, polymixin, pyrrolnitrin, quinolone, rifampin, rifamycins, rolitetracycline, roxithromycin, solithromycin, spiramycin, cstreptomycin, sulfabenzamide, sulfacetamide, sulfadiazine, sulfadoxine, sulfamerazine, sulfamethazine, sulfamethizole, sulfisoxazole, telithromycin, tetracycline, tigimonam, troleandomycin, tylosin, tylocine, vancomycin, zyvox, or combination thereof.