Modulators of hemoglobin

A compound of formula (I):

• or an isotopically enriched analog, stereoisomer, or mixture of stereoisomers thereof, or a pharmaceutically acceptable salt of each thereof,
• wherein:
• ring A is aryl or heteroaryl, wherein ring A is optionally substituted with 1-3 R3;
• ring B is aryl, nitrogen-containing heteroaryl, or nitrogen-containing heterocyclyl, wherein ring B is optionally substituted with 1-3 R4;
• L is absent, —C(O)—, —C(O)O—, or —CH2—;
• R1 is —C(O)H;
• R2 is H or OH;
• each R3 is independently halo, hydroxy, C1-3 alkyl, C2-3 alkenyl, C1-3 alkoxy, C1-3 haloalkyl, or C1-3 haloalkoxy;
• and
• each R4 is independently oxo, C1-3 alkyl, C1-3 alkoxy, C1-3 haloalkyl, C1-3 haloalkoxy, or C3-5 cycloalkyl.