Compositions and methods of enhancing immunogenicity of polysaccharide protein conjugates
AssigneeKanvax Biopharmaceuticals Ltd
InventorJianping Li
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Abstract
The present invention provides compositions and methods for enhancing immunogenicity of polysaccharide antigens. Immunogenic compositions and vaccines comprising polysaccharide-protein conjugates comprising a chimeric carrier protein having a universal epitope are provided. Methods of preparing the compositions, and methods for treating or preventing bacterial infections are further provided. The compositions and methods are useful for enhancing immune response in young children, elderly and immunocompromised individuals.
Claims19
A polysaccharide-protein conjugate comprising a) a chimeric carrier protein comprising i) a carrier protein and ii) a universal epitope, and b) a polysaccharide antigen, wherein:
- the carrier protein is derived from cross reacting materials (CRM) of diphtheria toxin,
- the universal epitope comprises the amino acid sequence of SEQ ID NO:2, and
- the polysaccharide antigen is derived from Streptococcus pneumoniae (Pn),
- wherein the universal epitope is covalently fused to the N- and/or C-terminus of the carrier protein, wherein the chimeric carrier protein comprises no more than three universal epitopes, and wherein the polysaccharide antigen is covalently conjugated to the chimeric carrier protein.
Dependencies are inferred from the claim text.