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US 11,013,793 B2Granted
Multivalent pneumococcal vaccines
AssigneeAffinivax, Inc.
InventorsRichard Malley, Yingjie Lu, Fan Zhang, Teresa J. Broering, Shite Sebastian, Velupillai Puvanesarajah, George R. Siber
Life of this patent
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Abstract
Technologies for the prevention and/or treatment of pneumococcal infections.
Claims16
A multivalent vaccine comprising fifteen or more species of immunogenic complexes, wherein each species of the immunogenic complexes comprises:
- (a) a biotinylated polysaccharide antigen comprising biotin and a polysaccharide antigen from a distinct Streptococcus pneumoniae serotype;
- and
- (b) a fusion protein comprising:
- (i) a biotin-binding moiety;
- and
- (ii) at least one polypeptide antigen comprising:
- a first polypeptide antigen comprising an SP1500 polypeptide or an antigenic fragment thereof;
- and
- a second polypeptide antigen comprising an SP0785 polypeptide or an antigenic fragment thereof;
- wherein the fusion protein comprises an amino acid sequence at least 90% identical to SEQ ID NO:6;
- and
- wherein in each species of the immunogenic complexes, the biotinylated polysaccharide antigen is non-covalently associated with the biotin-binding moiety of the fusion protein.
9 more elements
A method of making a multivalent vaccine, comprising mixing fifteen or more species of immunogenic complexes in a single formulation, wherein each species of the immunogenic complexes comprises:
- (a) a biotinylated polysaccharide antigen comprising biotin and a polysaccharide antigen from a distinct Streptococcus pneumoniae serotype;
- and
- (b) a fusion protein comprising:
- (i) a biotin-binding moiety;
- and
- (ii) at least one polypeptide antigen comprising one or more of:
- a first polypeptide antigen comprising an SP1500 polypeptide or an antigenic fragment thereof;
- and
- a second polypeptide antigen comprising an SP0785 polypeptide or an antigenic fragment thereof;
- wherein the fusion protein comprises an amino acid sequence at least 90% identical to SEQ ID NO:6;
- and
- wherein in each species of the immunogenic complexes, the biotinylated polysaccharide antigen is non-covalently associated with the biotin-binding moiety of the fusion protein.
9 more elements
Dependencies are inferred from the claim text.