Scaffold for alloprosthetic composite implant
AssigneeMAKO Surgical Corp.
InventorPeter M. Bonutti
Life of this patent
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Abstract
An alloprosthetic composite implant comprising includes a structural porous scaffold having a pore density profile corresponding to a density profile of bone to be replaced. A plurality of cells are seeded within pores of the porous scaffold and grown by incubation. The cells may include osteoblasts and/or stem cells to form the structure of the implant, and one or more cartilage layers may be grown on top of the scaffold. The pore density profile of the scaffold may be formed based on one or both of the bone density profile of the bone to be removed, and the bone density profile of the native bone that will be in contact with the alloprosthetic implant. A robot may be employed reo resect the native bone and also to shape the alloprosthetic implant to fit into place in the native bone.
Claims17
A method of implanting an alloprosthetic composite implant including an implant scaffold, the method comprising:
- determining a bone density profile of a bone of a patient to be contacted by the scaffold;
- forming the scaffold to have a pore density profile, wherein the pore density profile of the scaffold is formed based on the determined bone density profile of the bone of the patient;
- seeding a plurality of viable cells into the scaffold;
- incubating the scaffold including the plurality of viable cells to grow bone throughout the scaffold;
- after growing the bone throughout the scaffold, growing at least one layer of cartilage on top of the grown bone to produce the alloprosthetic composite implant having a first shape;
- robotically resecting native bone of a patient to have a particular geometry;
- and
- after growing the at least one layer of cartilage on top of the grown bone, fixing the alloprosthetic composite implant having the first shape to a stand, and intraoperatively robotically machining the alloprosthetic composite implant from the first shape into a second shape corresponding to the particular geometry while the alloprosthetic composite implant is fixed to the stand, the second shape being different than the first shape;
- and
- implanting the alloprosthetic composite implant having the second shape into patient adjacent the resected native bone of the patient,
- wherein a portion of the scaffold intended to contact the native bone is formed with a pore density profile based on the determined bone density profile of the bone of the patient to be contacted by the scaffold.
Dependencies are inferred from the claim text.