Back to results
US 11,008,594 B2Granted
Process for the preparation of triple-bond-containing optically active carboxylic acids, carboxylate salts and carboxylic acid derivatives
AssigneeChinoin Pharmaceutical and Chemical Works Private Company Ltd.
InventorsIrén Hortobágyi, István Lászlófi, Zsuzsanna Kardos, József Molnár, László Takács, Tamás Bán
Life of this patent
Estimating the term…
Abstract
The invention provides a new enzimatic process for the preparation of chiral carboxylic acids, their salts and acid derivatives of the general formula (I) by enzymatic hydrolysis of racemic carboxylic acid ester of the general formula (II) and optionally subsequent esterification or acylation.
Claims20
Process for the preparation of chiral carboxylic acids of general formula (I),
- where R is H or methyl group,
- wherein a racemic carboxylic acid ester of general formula (II),
- where R′ is Me, Et, Pr, i-Pr, Bu, and
- R is as defined above,
- is enzymatically hydrolysed using a hydrolase enzyme,
- thereby obtaining the chiral carboxylic acid of general formula (I).
3 more elements
Dependencies are inferred from the claim text.