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US 11,008,558 B2Granted
Compositions and methods for treating celiac sprue disease
AssigneeUniversity of Washington
InventorsJustin Bloomfield Siegel, David Baker, Ingrid Swanson Pultz
Life of this patent
Estimating the term…
Abstract
The invention provides compositions and methods for treating celiac sprue.
Claims14
A food product comprising:
- (a) gluten;
- and
- (b) one or more polypeptides comprising the amino acid sequence of a polypeptide selected from the group consisting of SEQ ID NOS:
- 74-77, 79-89, 95, 97-99, and 102-111, or processed versions thereof.
1 more element
A food product comprising:
- (a) gluten;
- and
- (b) a polypeptide selected from the following group, or processed versions thereof:
- i. SEQ ID NO:95, wherein one, two, three, four, five, six, seven, eight, nine, ten, or all eleven of the following are true:
- (i) AA residue 116 is V or D;
- (ii) AA residue 255 is S, K, or G;
- (iii) AA residue 284 is D;
- (iv) AA residue 285 is T;
- (v) AA residue 286 is A, T, or N;
- (vi) AA residue 312 is S;
- (vii) AA residue 347 is N;
- (viii) AA residue 350 is T or A;
- (ix) AA residue 351 is N or G;
- (x) AA residue 354 is D;
- and (xi) AA residue 361 is S or H;
- ii. SEQ ID NO:75, wherein one, two, three, four, five, six, seven, eight, nine, ten, or all eleven of the following are true:
- (i) AA residue 106 is D;
- (ii) AA residue 246 is S, K, or G;
- (iii) AA residue 275 is D;
- (iv) AA residue 276 is S;
- (v) AA residue 277 is A, T, or N;
- (vi) AA residue 303 is S;
- (vii) AA residue 338 is S;
- (viii) AA residue 341 is T or A;
- (ix) AA residue 342 is N or G;
- (x) AA residue 345 is Q or D;
- and (xi) AA residue 352 is S or H;
- iii. SEQ ID NO:76, wherein one, two, three, four, five, six, seven, eight, nine, ten, or all eleven of the following are true:
- (i) AA residue 120 is D;
- (ii) AA residue 259 is S, K, or G;
- (iii) AA residue 288 is D;
- (iv) AA residue 289 is T;
- (v) AA residue 290 is A, T, or N;
- (vi) AA residue 316 is S;
- (vii) AA residue 351 is S or N;
- (viii) AA residue 354 is A;
- (ix) AA residue 355 is N or G;
- (x) AA residue 358 is D;
- and (xi) AA residue 365 is S or H;
- iv. SEQ ID NO:79, wherein one, two, three, four, five, six, seven, eight, nine, ten, or all eleven of the following are true:
- (i) AA residue 107 is V or D;
- (ii) AA residue 245 is S, K, or G;
- (iii) AA residue 274 is D;
- (iv) AA residue 275 is T;
- (v) AA residue 276 is A, T, or N;
- (vi) AA residue 302 is S;
- (vii) AA residue 337 is S or N;
- (viii) AA residue 340 is T or A;
- (ix) AA residue 341 is N or G;
- (x) AA residue 344 is Q or D;
- and (xi) AA residue 351 is S or H;
- v. SEQ ID NO:80, wherein one, two, three, four, five, six, seven, eight, nine, ten, or all eleven of the following are true:
- (i) AA residue 76 is V or D;
- (ii) AA residue 206 is S, K, or G;
- (iii) AA residue 235 is D;
- (iv) AA residue 236 is S;
- (v) AA residue 237 is A, T, or N;
- (vi) AA residue 262 is S;
- (vii) AA residue 297 is S or N;
- (viii) AA residue 300 is T or A;
- (ix) AA residue 301 is N or G;
- (x) AA residue 302 is Q or D;
- and (xi) AA residue 309 is S or H;
- vi. SEQ ID NO:81, wherein one, two, three, four, five, six, seven, eight, nine, ten, or all eleven of the following are true:
- (i) AA residue 105 is D;
- (ii) AA residue 244 is S or K;
- (iii) AA residue 272 is D;
- (iv) AA residue 273 is S;
- (v) AA residue 274 is A, T, or N;
- (vi) AA residue 299 is S;
- (vii) AA residue 334 is N;
- (viii) AA residue 337 is T or A;
- (ix) AA residue 338 is N or G;
- (x) AA residue 341 is Q or D;
- and (xi) AA residue 348 is S or H;
- vii. SEQ ID NO:82, wherein one, two, three, four, five, six, seven, eight, nine, ten, or all eleven of the following are true:
- (i) AA residue 106 is V or D;
- (ii) AA residue 244 is S, K, or G;
- (iii) AA residue 273 is D;
- (iv) AA residue 274 is T;
- (v) AA residue 275 is A, T, or N;
- (vi) AA residue 301 is S;
- (vii) AA residue 336 is N;
- (viii) AA residue 339 is T or A;
- (ix) AA residue 340 is N or G;
- (x) AA residue 343 is D;
- and (viii) AA residue 350 is S or H;
- viii. SEQ ID NO:83, wherein one, two, three, four, five, six, seven, eight, nine, ten, or all eleven of the following are true:
- (i) AA residue 107 is V or D;
- (ii) AA residue 245 is S, K, or G;
- (iii) AA residue 274 is D;
- (iv) AA residue 275 is T;
- (v) AA residue 276 is A, T, or N;
- (vi) AA residue 302 is S;
- (vii) AA residue 337 is N;
- (viii) AA residue 340 is T or A;
- (ix) AA residue 341 is N or G;
- (x) AA residue 344 is Q or D;
- and (xi) AA residue 351 is S or H;
- ix. SEQ ID NO:84, wherein one, two, three, four, five, six, seven, eight, nine, ten, or all eleven of the following are true:
- (i) AA residue 104 is V or D;
- (ii) AA residue 241 is S, K, or G;
- (iii) AA residue 270 is D;
- (iv) AA residue 271 is S;
- (v) AA residue 272 is D, A, T, or N;
- (vi) AA residue 398 is S;
- (vii) AA residue 33 is S;
- (viii) AA residue 336 is A;
- (ix) AA residue 337 is N or G;
- (x) AA residue 340 is D;
- and (xi) AA residue 347 is S or H;
- x. SEQ ID NO:85, wherein one, two, three, four, five, six, seven, eight, nine, ten, or all eleven of the following are true:
- (i) AA residue 104 is D;
- (ii) AA residue 245 is S, K, or G;
- (iii) AA residue 274 is D;
- (iv) AA residue 275 is S;
- (v) AA residue 276 is A, T, or N;
- (vi) AA residue 302 is S;
- (vii) AA residue 337 is S or N;
- (viii) AA residue 340 is T or A;
- (ix) AA residue 341 is N or G;
- (x) AA residue 344 is Q or D;
- and (xi) AA residue 351 is S or H;
- xi. SEQ ID NO:86, wherein one, two, three, four, five, six, seven, eight, nine, ten, or all eleven of the following are true:
- (i) AA residue 118 is V or D;
- (ii) AA residue 250 is K or G;
- (iii) AA residue 279 is D;
- (iv) AA residue 280 is S;
- (v) AA residue 281 is A, T, or N;
- (vi) AA residue 307 is S;
- (vii) AA residue 342 is S or N;
- (viii) AA residue 345 is A;
- (ix) AA residue 346 is N or G;
- (x) AA residue 349 is Q or D;
- and (xi) AA residue 356 is S or H;
- xii. SEQ ID NO:87, wherein one, two, three, four, five, six, seven, eight, nine, ten, or all eleven of the following are true:
- (i) AA residue 121 is V or D;
- (ii) AA residue 253 is S, K, or G;
- (iii) AA residue 282 is D;
- (iv) AA residue 283 is S;
- (v) AA residue 284 is A, T, or N;
- (vi) AA residue 310 is S;
- (vii) AA residue 345 is S;
- (viii) AA residue 348 is T or A;
- (ix) AA residue 349 is N or G;
- (x) AA residue 352 is Q or D;
- and (xi) AA residue 357 is S or H;
- and
- xiii. SEQ ID NO:88, wherein one, two, three, four, five, six, seven, eight, nine, or all ten of the following are true:
- (i) AA residue 111 is S, K, or G;
- (ii) AA residue 139 is D;
- (iii) AA residue 140 is T or S;
- (iv) AA residue 141 is D, A, T, or N;
- (v) AA residue 164 is S;
- (vi) AA residue 199 is S or N;
- (vii) AA residue 202 is T or A;
- (viii) AA residue 203 is N or G;
- (ix) AA residue 204 is Q or D;
- and (x) AA residue 211 is S or H.
156 more elements
Dependencies are inferred from the claim text.