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US 11,008,362 B2Granted
Malonyl-coenzyme A mimics as fatty acid synthase inhibitors and methods of use
AssigneePurdue Research Foundation
InventorsJeremy R. Lohman, Lee M. Stunkard
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Abstract
The present disclosure generally relates to novel compounds as a fatty acid synthase inhibitor useful for the treatment of infection diseases, cancers, or metabolic diseases that malfunction of fatty acid synthase is involved. In particular this present invention directs to malonyl-coenzyme A (CoA) mimetics and methods of use thereof. The invention described herein also pertains to pharmaceutical compositions and methods for treating diseases in mammals using compounds disclosed herein.
Claims10
A compound having a formula
- or a pharmaceutically acceptable salt, hydrate, or solvate thereof, wherein
- X is co-enzyme A (CoA) or
- Y is methylene (—CH2—), S, SO, NH, or O;
- Z is N, S or SO;
- and
- R1 is hydrogen, an alkyl, alkenyl, or alkynyl.
3 more elements
Dependencies are inferred from the claim text.