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US 11,008,334 B2Granted
Compositions and methods for treating cancer
AssigneeThe Regents of the University of California
InventorsJonathan Ostrem, Ulf Peters, Kevan M. Shokat
Life of this patent
Estimating the term…
Abstract
K-Ras is the most frequently mutated oncogene in human cancer. Disclosed herein are compositions and methods for modulating K-Ras and treating cancer.
Claims10
A K-Ras protein covalently bonded to a compound, wherein the compound is covalently bonded to cysteine residue 12 of the K-Ras protein and is in contact with one or more amino acid residues of a K-Ras protein Switch 2 binding pocket.
Dependencies are inferred from the claim text.